Chemoradiotherapy for locally advanced head and neck cancer: 10-year follow-up of the UK Head and Neck (UKHAN1) trial

The Lancet Oncology

Volumn 11, Issue 1, 2010, Pages 66-74

  Tobias, Jeffrey S ^a   Monson, Kathryn ^b   Gupta, Nirmal ^c   MacDougall, Hugh ^d   Glaholm, John ^e   Hutchison, Iain ^f   Kadalayil, Latha ^g   Hackshaw, Allan ^g  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^b BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^f ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; BLEOMYCIN; FLUOROURACIL; HYDROCORTISONE; METHOTREXATE; VINCRISTINE;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG FATALITY; DRUG WITHDRAWAL; EVENT FREE SURVIVAL; FEMALE; HEAD AND NECK CANCER; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MUCOSA INFLAMMATION; MULTICENTER STUDY; OVERALL SURVIVAL; PATIENT COMPLIANCE; PRIORITY JOURNAL; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLEOMYCIN; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; GREAT BRITAIN; HEAD AND NECK NEOPLASMS; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MALTA; METHOTREXATE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY, ADJUVANT; RISK ASSESSMENT; TIME FACTORS; TREATMENT OUTCOME; TURKEY; VINCRISTINE; YOUNG ADULT;

EID: 73249127003     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(09)70306-7     Document Type: Article

References (20)

1. Sankaranarayanan R., Masuyer E., Swaminathan R., Ferlay J., and Whelan S. Head and neck cancer: a global perspective on epidemiology and prognosis. Anticancer Res 18 (1998) 4779-4786
2. Zeka A., Gore R., and Kriebel D. Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis. Cancer Causes Control 14 (2003) 897-906
3. Canto M.T., and Devesa S.S. Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998. Oral Oncol 38 (2002) 610-617
4. Stell P.M., and Rawson N.S. Adjuvant chemotherapy in head and neck cancer. Br J Cancer 61 (1990) 779-787
5. Marcial V.A., Pajak T.F., Kramer S., et al. Radiation Therapy Oncology Group (RTOG) studies in head and neck cancer. Semin Oncol 15 (1988) 39-60
6. Pignon J.P., Bourhis J., Domenge C., and Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355 (2000) 949-955
7. Pignon J.P., le Maître A., Maillard E., Bourhis J., and on behalf of the MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 92 (2009) 4-14
8. Tobias J.S., Monson K., Gupta N., et al. Does chemotherapy have a role in the management of patients with advanced head and neck cancer? Early results from the UK Head and Neck (UKHAN) Trial. Proc Am Soc Clin Oncol 20 (2001) abstr 888.
9. SECOG Trialists Group. A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck. An interim report from the SECOG participants. South-East Co-operative Oncology Group. Eur J Surg Oncol 12 (1986) 289-295
10. Gupta N.K., Pointon R.C., and Wilkinson P.M. A randomised clinical trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer. Clin Radiol 38 (1987) 575-581
11. Gupta N.K., and Swindell R. Concomitant methotrexate and radiotherapy in advanced head and neck cancer: 15-year follow-up of a randomized clinical trial. Clin Oncol 13 (2001) 339-344
12. Bernier J., Domenge C., Ozsahin M., et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350 (2004) 1945-1952
13. Cooper J.S., Pajak T.F., Forastiere A.A., et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350 (2004) 1937-1944
14. Pointreau Y., Garaud P., Chapet S., et al. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst 101 (2009) 498-506
15. Vermorken J.B., Mesia R., Rivera F., et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359 (2008) 1116-1127
16. Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354 (2006) 567-578
17. Psyrri A., Gouveris P., and Vermorken J.B. Human papillomavirus-related head and neck tumors: clinical and research implication. Curr Opin Oncol 21 (2009) 201-205
18. Fakhry C., Westra W.H., Li S., et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100 (2008) 261-269
19. Lassen P., Eriksen J.G., Hamilton-Dutoit S., Tramm T., Alsner J., and Overgaard J. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 27 (2009) 1992-1998
20. Tobias J.S. Cancer of the head and neck. BMJ 308 (1994) 961-966