Tailoring the treatment of locally advanced squamous cell carcinoma of the vulva: Neoadjuvant chemotherapy followed by radical surgery: Results from a multicenter study

International Journal of Gynecological Cancer

Volumn 22, Issue 7, 2012, Pages 1258-1263

  Aragona, Alejandro M ^a,b   Cuneo, Nicasio ^a   Soderini, Alejandro H ^a   Alcoba, Elsa ^a   Greco, Adriana ^c   Reyes, Carlos ^c   Lekmann, Silvia ^c  

^a Division of Anatomic Pathology   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Hosp Gen Agudos Parmenio T Pinero   (Argentina)

Author keywords

Neoadjuvant chemotherapy; Radical surgery; Vulvar cancer

Indexed keywords

BLEOMYCIN; CISPLATIN; FLUOROURACIL; LYPRESSIN; PACLITAXEL; VINCRISTINE; ANTINEOPLASTIC AGENT;

ADULT; ADVANCED CANCER; AGED; BILATERAL INGUINOFEMORAL LYMPHADENECTOMY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CONFERENCE PAPER; FEMALE; FOLLOW UP; GYNECOLOGIC SURGERY; HUMAN; MULTICENTER STUDY; OUTCOME ASSESSMENT; POSTERIOR PELVIC EXENTERATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL CARCINOMA OF THE VULVA; TREATMENT RESPONSE; VULVA CARCINOMA; VULVECTOMY; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ARTICLE; CANCER STAGING; FEASIBILITY STUDY; LYMPH NODE DISSECTION; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PELVIS EXENTERATION; PROGNOSIS; SURVIVAL RATE; VULVA TUMOR;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PELVIC EXENTERATION; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE; VULVAR NEOPLASMS;

EID: 84873261199     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e318263ef55     Document Type: Conference Paper

References (25)

1. Benedet JL, Bender H, Jones H 3rd, et al. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet. 2000;70:209-262.
2. Judson PL, Habermann EB, Baxter NN, et al. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol. 2006;107:1018-1022.
3. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin. 2006;56:106-130.
4. Stroup AM, Harlan LC, Trimble EL. Demographic, clinical and treatment trends among women diagnosed with vulvar cancer in the United States. Gynecol Oncol. 2008;108:577-583.
5. Aragona A, Cuneo N, Soderini A. Epidemiología del cáncer ginecológico. Jornadas del 80 Aniversario del Hospital Oncológico Municipal María Curie, CABA 27 de Marzo de. 2011.
6. Aragona A, Cuneo N, Soderini A. Quimioterapia neoadyuvante (QN) en el carcinoma avanzado de la vulva (CAV). XII Congreso Internacional SOGBAVXXIII Jornadas Internacionales de la Sociedad de Obstetricia y Ginecología de Mar del Plata, 10 de Diciembre de. Meeting, 2010.
7. Eifel PJ, Morris M, Burke TW, et al. Preoperative continuous infusion cisplatinum and 5-fluorouracil with radiation for locally advanced or recurrent carcinoma of the vulva. Gynecol Oncol. 1995;59:51-56.
8. Landoni F, Maneo A, Zanetta G, et al. Concurrent preoperative chemotherapy with 5-flourouracil and mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma. Gynecol Oncol. 1996;61:321-327.
9. Lupi F, Raspagliesi F, Zucali R, et al. Combined preoperative chemoradiotherapy followed by radical surgery in locally advanced and recurrent vulvar carcinoma: a pilot study. Cancer. 1996;77:1472-1478.
10. Bortolozzi G, Arnoletti E, Belloni C, et al. New integrated therapy in vulvar cancer. Proceedings of International Meeting of Gynecologic Oncology. 1985;420.
11. Strzinar V, Kocijan A, Kovacic, J, et al. Adriamycin and bleomycin in treatment of advanced or recurrent squamous cell carcinoma of the vulva. Proceedings of International Meeting of Gynecologic Oncology. 1985;408:15-19.
12. Itala J, Belardi G, Sardi J, et al. Poliquimioterapia neoadyuvante en el tratamiento del carcinoma invasor de la vulva. Revista de la Sociedad de Obstetricia y Ginecología de Buenos Aires (SOGIBA). 1986;865:239-245.
13. Shimizu Y, Hasumi K, Masubuchi K. Effective chemotherapy consisting of bleomycin, vincristine, mitomycin C, and cisplatin (BOMP) for a patient with inoperable vulvar cancer. Gynecol Oncol. 1990;36:423-427.
14. Benedetti-Panici P, Greggi S, Scambia G, et al. Cisplatin (P), bleomycin (B), and methotrexate (M) preoperative chemotherapy in locally advanced vulvar carcinoma. Gynecol Oncol. 1993;50:49-53.
15. Belinson JL, Stewart JA, Richards AL, et al. Bleomycin, vincristine, mitomycin-C, and cisplatin in the management of gynecologic squamous cell carcinomas. Gynecol Oncol. 1985;20:387-393.
16. Wagenaar HC, Colombo N, Vergote I, et al. Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group Study. European Organization for Research and Treatment of Cancer. Gynecol Oncol. 2001;81:348.
17. Geisler JP, Manahan KJ, Buller RE. Neoadjuvant chemotherapy in vulvar cancer: avoiding primary exenteration. Gynecol Oncol. 2006;100:53-57.
18. Witteveen PO, Van der Velden J, Vergote I, et al. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of CancerVGynaecological Cancer Group). Ann Oncol. 2009;20:1511-1516.
19. Domingues AP, Mota F, Durão M, et al. Neoadjuvant chemotherapy in advanced vulvar cancer. Int J Gynecol Cancer. 2010;20:294-298.
20. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
21. Sardi J, Sananes C, Giaroli A, et al. Results of a prospective randomized trial with neoadjuvant chemotherapy in stage IB, bulky, squamous carcinoma of the cervix. Gynecol Oncol. 1993;49:156-165.
22. Thomas G, Dembo A, De Petrillo A, et al. Concurrent radiation and chemotherapy in vulvar carcinoma. Gynecol Oncol. 1989;34:263-267.
23. Hoffman MS. Squamous-cell carcinoma of the vulva: locally advanced disease. Best Pract Res Clin Obstet Gynaecol. 2003;17:635-647.
24. Dhar KK, Woolas RP. Changes in the management of vulval cancer. Best Pract Res Clin Obstet Gynaecol. 2003;17:529-542.
25. De Hullu JA, Oonk MH, van der Zee AG. Modern management of vulvar cancer. Curr Opin Obstet Gynecol. 2004;16:65-72.