Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells

Chemistry and Biology

Volumn 18, Issue 4, 2011, Pages 445-453

  Fonseca, Sonali B ^a   Pereira, Mark P ^b   Mourtada, Rida ^a   Gronda, Marcela ^c   Horton, Kristin L ^b   Hurren, Rose ^c   Minden, Mark D ^c   Schimmer, Aaron D ^c   Kelley, Shana O ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORAMBUCIL;

ALKYLATION; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; DNA DAMAGE; DRUG EFFECT; DRUG RESISTANCE; GENETICS; HELA CELL; HUMAN; METABOLISM; MITOCHONDRION; NEOPLASM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ALKYLATION; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CHLORAMBUCIL; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; HELA CELLS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MITOCHONDRIA; NEOPLASMS;

EID: 79955385201     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.02.010     Document Type: Article

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