Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design

Protein Science

Volumn 22, Issue 8, 2013, Pages 1071-1077

  Singh, Onkar ^a   Shillings, Anthony ^a   Craggs, Peter ^a   Wall, Ian ^a   Rowland, Paul ^a   Skarzynski, Tadeusz ^b   Hobbs, Clare I ^a   Hardwick, Phil ^a   Tanner, Rob ^a   Blunt, Michelle ^a   Witty, David R ^c   Smith, Kathrine J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b AGILENT TECHNOLOGIES   (United Kingdom)

^c Babraham Research Campus ^*  (United Kingdom)

Author keywords

Apoptosis signal regulating kinase 1; ASK1; Structure base drug design

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS SIGNAL REGULATING KINASE 1; APOPTOSIS SIGNAL REGULATING KINASE 1 INHIBITOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG DETERMINATION; ENZYME STRUCTURE; PRIORITY JOURNAL; X RAY;

APOPTOSIS SIGNAL REGULATING KINASE 1; ASK1; STRUCTURE BASE DRUG DESIGN;

BINDING SITES; CARDIOVASCULAR DISEASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; MAP KINASE KINASE KINASE 5; NEOPLASMS; NEURODEGENERATIVE DISEASES; SF9 CELLS; SIGNAL TRANSDUCTION; STAUROSPORINE;

EID: 84881280396     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2298     Document Type: Article

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