Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells

Biochemical and Biophysical Research Communications

Volumn 460, Issue 2, 2015, Pages 380-385

  Li, Kuiqing ^a   Chen, Xu ^a   Liu, Cheng ^a   Gu, Peng ^a   Li, Zhuohang ^a   Wu, Shaoxu ^a   Xu, Kewei ^a   Lin, Tianxin ^a   Huang, Jian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Bladder cancer; mTOR; Pirarubicin

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; MTOR PROTEIN, HUMAN; PIRARUBICIN; TARGET OF RAPAMYCIN KINASE;

ANALOGS AND DERIVATIVES; APOPTOSIS; AUTOPHAGY; BLADDER TUMOR; DRUG EFFECTS; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; DOXORUBICIN; HUMANS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; URINARY BLADDER NEOPLASMS;

EID: 84937763365     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.042     Document Type: Article

References (32)

1. M. Babjuk, M. Burger, and R. Zigeuner EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013 Eur. Urol. 64 2013 639 653
2. M. Ploeg, K.K. Aben, and L.A. Kiemeney The present and future burden of urinary bladder cancer in the world World J. Urol. 27 2009 289 293
3. R.J. Sylvester, W. Oosterlinck, and A.P. van der Meijden A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials J. Urol. 171 2004 2186 2190 quiz 2435
4. Y. Yamamoto, Y. Nasu, and T. Saika The absorption of pirarubicin instilled intravesically immediately after transurethral resection of superficial bladder cancer Bju Int. 86 2000 802 804
5. A. Ito, I. Shintaku, and M. Satoh Prospective randomized phase II trial of a single early intravesical instillation of pirarubicin (THP) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma: the THP monotherapy study group trial J. Clin. Oncol. 31 2013 1422 1427
6. C. Behrends, M.E. Sowa, and S.P. Gygi Network organization of the human autophagy system Nature 466 2010 68 76
7. K. Sun, W. Deng, and S. Zhang Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells Cell. Biosci. 3 2013 35
8. T. Li, L. Su, and N. Zhong Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells Autophagy 9 2013 1057 1068
9. M. Elgendy, C. Sheridan, and G. Brumatti Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival Mol. Cell. 42 2011 23 35
10. I. Tanida, N. Minematsu-Ikeguchi, and T. Ueno Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy Autophagy 1 2005 84 91
11. M. Komatsu, Q.J. Wang, and G.R. Holstein Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration Proc. Natl. Acad. Sci. U. S. A. 104 2007 14489 14494
12. M. Komatsu, S. Waguri, and M. Koike Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 2007 1149 1163
13. X. Liao, J.C. Sluimer, and Y. Wang Macrophage autophagy plays a protective role in advanced atherosclerosis Cell. Metab. 15 2012 545 553
14. S. Zhu, L. Cao, and Y. Yu Inhibiting autophagy potentiates the anticancer activity of IFN1@IFNalpha in chronic myeloid leukemia cells Autophagy 9 2013 317 327
15. R. Mathew, C.M. Karp, and B. Beaudoin Autophagy suppresses tumorigenesis through elimination of p62 Cell 137 2009 1062 1075
16. R. Singh, and A.M. Cuervo Leucine deprivation triggers melanoma apoptosis Cell. Metab. 13 2011 495 504
17. D.A. Gewirtz Autophagy and senescence in cancer therapy J. Cell. Physiol. 229 2014 6 9
18. R. Pinto-Leite, R. Arantes-Rodrigues, and R. Ferreira Temsirolimus improves cytotoxic efficacy of cisplatin and gemcitabine against urinary bladder cancer cell lines Urol. Oncol. 32 2014 41.e11 41.e22
19. M. Santoni, C. Amantini, and M.B. Morelli Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells Br. J. Cancer 109 2013 1040 1050
20. R.J. Dickstein, G. Nitti, and C.P. Dinney Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells Cancer Biol. Ther. 13 2012 1325 1338
21. M.N. Becker, K.J. Wu, and L.A. Marlow The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro Urol. Oncol. 32 2014 317 326
22. M. Moschetta, A. Reale, and C. Marasco Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations Br. J. Pharmacol. 171 2014 3801 3813
23. J. Karar, G.J. Cerniglia, and T. Lindsten Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1Á expression by blocking protein translation and increases cell death under hypoxia Cancer Biol. Ther. 13 2012 1102 1111
24. F. Bahrami, M.H. Pourgholami, and A.H. Mekkawy Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway Am. J. Cancer Res. 4 2014 558 571
25. H. Zhou, T. Shen, and C. Shang Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway Oncotarget 5 2014 10140 10150
26. M. Cicchini, R. Chakrabarti, and S. Kongara Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity Autophagy 10 2014
27. J. Pratt, and B. Annabi Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells Cell. Signal 26 2014 917 924
28. A.M. Taherbhoy, S.W. Tait, and S.E. Kaiser Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway Mol. Cell. 44 2011 451 461
29. D.J. Klionsky, F.C. Abdalla, and H. Abeliovich Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy 8 2012 445 544
30. J.Y. Guo, H.Y. Chen, and R. Mathew Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis Genes. Dev. 25 2011 460 470
31. R.K. Amaravadi, J. Lippincott-Schwartz, and X.M. Yin Principles and current strategies for targeting autophagy for cancer treatment Clin. Cancer Res. 17 2011 654 666
32. K.N. Townsend, L.R. Hughson, and K. Schlie Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity Immunol. Rev. 249 2012 176 194