Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 10, 2015, Pages 2169-2173

  Glunz, Peter W ^a   Cheng, Xuhong ^a   Cheney, Daniel L ^a   Weigelt, Carolyn A ^a   Wei, Anzhi ^a   Luettgen, Joseph M ^a   Wong, Pancras C ^a   Wexler, Ruth R ^a   Priestley, E Scott ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Amide isosteres; Factor; Serine protease inhibitors; TF FVIIa inhibitor; Tissue factor; VIIa

Indexed keywords

BLOOD CLOTTING FACTOR 7A; IMIDAZOLE DERIVATIVE; SERINE PROTEINASE INHIBITOR;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; IMIDAZOLES; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS;

EID: 84937760195     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.03.062     Document Type: Article

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