Assessment of bleeding propensity in non-human primates by combination of selective tissue factor/VIIa inhibition and aspirin compared to warfarin and aspirin treatment

Pharmacology

Volumn 70, Issue 2, 2004, Pages 100-106

  Salyers, Anita K ^a   Szalony, James A ^a   Suleymanov, Osman D ^a   Parlow, John J ^a   Wood, Rhonda S ^a   South, Michael S ^a   Nicholson, Nancy S ^a  

^a PFIZER INC   (United States)

Author keywords

Anticoagulation; Bleeding; Thrombosis; Tissue factor

Indexed keywords

3 AMINO 5 [1 [2 [[4 [AMINO(IMINO)METHYL]BENZYL]AMINO] 2 OXOETHYL] 3 CHLORO 5 (ISOPROPYLAMINO) 6 OXO 1,6 DIHYDROPYRAZIN 2 YL]BENZOIC ACID; ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 7A INHIBITOR; PHA 927; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLEEDING TIME; CARDIOVASCULAR RISK; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; INFUSION; MACACA; MALE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

AMINOBENZOIC ACIDS; ANIMALS; ANTICOAGULANTS; ASPIRIN; BLEEDING TIME; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FACTOR VIIA; HEMORRHAGE; MACACA FASCICULARIS; MALE; PLATELET AGGREGATION INHIBITORS; PROTHROMBIN TIME; PYRAZINES; THROMBOPLASTIN; WARFARIN; WHOLE BLOOD COAGULATION TIME;

EID: 0347418242     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074674     Document Type: Article

References (16)

1. Morbidity and Mortality: 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases: National Heart, Lung, and Blood Institute, Bethesda, May 2002.
2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;ii:349-360.
3. Antiplatelet Trialists' Collaboration: Collaborative overview of randomized trials of anti-platelet therapy. I. Prevention of death, myocardial infarction and stroke by prolonged anti-platelet therapy in various categories of patients. BMJ 1994;308:81-106.
4. Awtry EJ, Loscalzo J: Aspirin. Circulation 2000;101:1206-1218.
5. LeParc JM, Van Ganse E, Moore N, Schneid H, Verrière F: Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions:results in 4291 patients. Clin Rheumatol 2002;21:28-31.
6. Smith P, Arnesen H, Holme I: The effect of warfarin on mortality and reinfarction after myocardial infarction. N Engl J Med 1990;323: 147-152.
7. Coumadin Aspirin Reinfarction Study (CARS) Investigators: Randomized double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction. Lancet 1997;350:389-396.
8. Fiore L, Ezekowitz MD, Brophy MT, Lu D, Sacco J, Peduzzi P: Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: Primary results of the CHAMP study. Circulation 2002;105:557-563.
9. Becker RC: Antithrombotic therapy after myocardial infarction. N Engl J Med 2002;347: 1019-1022.
10. Hurlen M, Abdelnoor M, Smith P, Erikssen J, Arnesen H: Warfarin, aspirin or both after myocardial infarction. N Engl J Med 2002;347: 969-974.
11. Brouwer MA, van den Bergh PJ, Aengevaeren WR, Veen G, Luijten HE, Hertzberger DP, van Boven AJ, Vromans RP, Uijen GJ, Verheugt FW: Aspirin plus coumarin versus aspirin alone in the prevention of reocclusion after fibrinolysis for acute myocardial infarction: Results of the Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis (APRICOT)-2 Trial. Circulation 2002; 106:659-665.
12. Harker LA, Hanson SR, Wilcox JN, Kelly AB: Antithrombotic and antilesion benefits without hemorrhagic risks by inhibiting tissue factor pathway. Haemostasis 1996;26(suppl 1):76-82.
13. Himber J, Kirchhofer D, Riedereer M, Tschopp TB, Steiner B, Roux SP: Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function. Thromb Haemost 1997;78:1142-1149.
14. Zoldhelyi P, McNatt J, Shelat HS, Yamamoto Y, Chen Z-Q, Willerson JT: Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor. Circulation 2000;101: 289-295.
15. Giesen PLA, Rauch U, Bohrmann B, Kling D, Roque M, Fallon JT, Badimon JJ, Himber J, Riederere MA, Nemerson Y: Blood-borne tissue factor: Another view of thrombosis. Proc Natl Acad Sci 1999;96:2311-2315.
16. Szalony JA, Taite BB, Girard TJ, Nicholson NS, LaChance RM: Pharmacological intervention at disparate sites in the coagulation cascade: Comparison of anti-thrombotic efficacy vs. bleeding propensity in a rat model of acute arterial thrombosis. J Thromb Thrombolysis 2003;14:113-121.