Design, synthesis and biological evaluation of pyridazino[3,4,5-de]quinazolin-3(2H)-one as a new class of PARP-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 11, 2015, Pages 2340-2344

  Wang, Jie ^a   Tan, Hailiang ^a   Sun, Qi ^a   Ge, Zemei ^a   Wang, Xin ^a   Wang, Yinye ^a   Li, Runtao ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Combination strategy; Molecular docking; Neuroprotectivity; PARP 1 inhibitor; Pyridazino 3,4,5 de quinazolin 3(2H) one

Indexed keywords

8-(P-TOLYL)-2H-PYRIDAZINO(3,4,5-DE)QUINAZOLIN-3(9H)-ONE; 8-PHENYL-2H-PYRIDAZINO(3,4,5-DE)QUINAZOLIN-3(9H)-ONE; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN BINDING; PYRIDAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; METABOLISM; PC12 CELL LINE; RAT;

ANIMALS; CATALYTIC DOMAIN; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PC12 CELLS; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; PYRIDAZINES; QUINAZOLINES; RATS;

EID: 84937759395     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.04.013     Document Type: Article

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