Design, synthesis and biological evaluation of novel imidazo[4,5-c] pyridinecarboxamide derivatives as PARP-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 1993-1996

  Zhu, Qihua ^a   Wang, Xuyan ^a   Chu, Zhaoxing ^b   He, Guangwei ^b   Dong, Guangping ^a   Xu, Yungen ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Hefei Yi Gong Pharmaceutical Co Ltd   (China)

Author keywords

Antitumor; Imidazo 4,5 c pyridinecarboxamide; PARP inhibitors; PARP 1

Indexed keywords

4 AMINO 5 NITRONICOTINAMIDE; 4,5 DIAMINONICOTINAMIDE; AMIDE; CISPLATIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VELIPARIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPROTECTION REACTION; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84875226877     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.032     Document Type: Article

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