메뉴 건너뛰기




Volumn 40, Issue 5, 2015, Pages 1074-1082

Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in Prenatally Stressed Offspring Rats

Author keywords

Brain derived neurotrophic factor (BDNF); Depression like and anxiety like behaviors; Metabotropic glutamate receptor 1 5 (mGluR1 5); Prenatal stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GRM5 PROTEIN, RAT; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5;

EID: 84937759276     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1565-6     Document Type: Article
Times cited : (40)

References (51)
  • 2
    • 78650124390 scopus 로고    scopus 로고
    • Comorbidity of anxiety and depression in youth: implications for treatment and prevention
    • Garber J, Weersing VR (2010) Comorbidity of anxiety and depression in youth: implications for treatment and prevention. Clin Psychol: Sci Pract 17:293–306
    • (2010) Clin Psychol: Sci Pract , vol.17 , pp. 293-306
    • Garber, J.1    Weersing, V.R.2
  • 3
    • 80054116238 scopus 로고    scopus 로고
    • Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
    • COI: 1:CAS:528:DC%2BC3MXhtlaktbnI, PID: 21827775
    • Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62:63–77
    • (2012) Neuropharmacology , vol.62 , pp. 63-77
    • Sanacora, G.1    Treccani, G.2    Popoli, M.3
  • 4
    • 84855557076 scopus 로고    scopus 로고
    • Roles of glutamate signaling in preclinical and/or mechanistic models of depression
    • COI: 1:CAS:528:DC%2BC38XltVehug%3D%3D, PID: 21536063
    • Tokita K, Yamaji T, Hashimoto K (2012) Roles of glutamate signaling in preclinical and/or mechanistic models of depression. Pharmacol Biochem Behav 100:688–704
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 688-704
    • Tokita, K.1    Yamaji, T.2    Hashimoto, K.3
  • 5
    • 78650350899 scopus 로고    scopus 로고
    • Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation
    • COI: 1:CAS:528:DC%2BC3cXhsFyks7vM, PID: 21034292
    • Paris JJ, Frye CA (2011) Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation. Stress 14:23–32
    • (2011) Stress , vol.14 , pp. 23-32
    • Paris, J.J.1    Frye, C.A.2
  • 6
    • 84155160658 scopus 로고    scopus 로고
    • The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
    • PID: 22127301
    • Popoli M, Yan Z, McEwen BS, Sanacora G (2011) The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci 13:22–37
    • (2011) Nat Rev Neurosci , vol.13 , pp. 22-37
    • Popoli, M.1    Yan, Z.2    McEwen, B.S.3    Sanacora, G.4
  • 8
    • 84884970235 scopus 로고    scopus 로고
    • Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring
    • COI: 1:CAS:528:DC%2BC3sXhsleit77J, PID: 24029697
    • Sun H, Jia N, Guan L, Su Q, Wang D, Li H, Zhu Z (2013) Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring. Behav Brain Res 257:1–7
    • (2013) Behav Brain Res , vol.257 , pp. 1-7
    • Sun, H.1    Jia, N.2    Guan, L.3    Su, Q.4    Wang, D.5    Li, H.6    Zhu, Z.7
  • 9
    • 84882686316 scopus 로고    scopus 로고
    • Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress
    • COI: 1:CAS:528:DC%2BC3sXhsVWjtLnL, PID: 23694703
    • Zhang XH, Jia N, Zhao XY, Tang GK, Guan LX, Wang D, Sun HL, Li H, Zhu ZL (2013) Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress. Neuroscience 250:333–341
    • (2013) Neuroscience , vol.250 , pp. 333-341
    • Zhang, X.H.1    Jia, N.2    Zhao, X.Y.3    Tang, G.K.4    Guan, L.X.5    Wang, D.6    Sun, H.L.7    Li, H.8    Zhu, Z.L.9
  • 10
    • 2942650911 scopus 로고    scopus 로고
    • Functional interaction between NMDA and mGluS receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release
    • COI: 1:CAS:528:DC%2BD2cXkvFWltrc%3D, PID: 15010696
    • Homayoun H, Stefani MR, Adams BW, Tamagan GD, Moghaddam B (2004) Functional interaction between NMDA and mGluS receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 29:1259–1269
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1259-1269
    • Homayoun, H.1    Stefani, M.R.2    Adams, B.W.3    Tamagan, G.D.4    Moghaddam, B.5
  • 11
    • 42949123365 scopus 로고    scopus 로고
    • Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    • COI: 1:CAS:528:DC%2BD1cXlt1agtbw%3D, PID: 18425072
    • Sanacora G, Zarate CA, Krystal JH, Manji HK (2008) Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov 7:426–437
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 426-437
    • Sanacora, G.1    Zarate, C.A.2    Krystal, J.H.3    Manji, H.K.4
  • 13
    • 84878396787 scopus 로고    scopus 로고
    • Glutamate-based antidepressants: preclinical psychopharmacology
    • COI: 1:CAS:528:DC%2BC3sXjsFCnsr4%3D, PID: 23453290
    • Pilc A, Wieronska JM, Skolnick P (2013) Glutamate-based antidepressants: preclinical psychopharmacology. Biol Psychiatry 73:1125–1132
    • (2013) Biol Psychiatry , vol.73 , pp. 1125-1132
    • Pilc, A.1    Wieronska, J.M.2    Skolnick, P.3
  • 14
    • 0032989730 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors: implications for brain diseases
    • COI: 1:CAS:528:DyaK1MXktlSgsb4%3D, PID: 10416961
    • Bordi F, Ugolini A (1999) Group I metabotropic glutamate receptors: implications for brain diseases. Prog Neurobiol 59:55–79
    • (1999) Prog Neurobiol , vol.59 , pp. 55-79
    • Bordi, F.1    Ugolini, A.2
  • 16
    • 0034667345 scopus 로고    scopus 로고
    • Neuroimaging studies of mood disorders
    • COI: 1:STN:280:DC%2BD3crht1Shtg%3D%3D, PID: 11063977
    • Drevets WC (2000) Neuroimaging studies of mood disorders. Biol Psychiatry 48:813–829
    • (2000) Biol Psychiatry , vol.48 , pp. 813-829
    • Drevets, W.C.1
  • 17
    • 77950055484 scopus 로고    scopus 로고
    • Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo
    • COI: 1:CAS:528:DC%2BC3cXktlGhsrg%3D, PID: 20193665
    • Shaffer C, Guo M-L, Fibuch EE, Mao L-M, Wang JQ (2010) Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo. Brain Res 1326:184–192
    • (2010) Brain Res , vol.1326 , pp. 184-192
    • Shaffer, C.1    Guo, M.-L.2    Fibuch, E.E.3    Mao, L.-M.4    Wang, J.Q.5
  • 19
    • 33751190762 scopus 로고    scopus 로고
    • Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
    • COI: 1:CAS:528:DC%2BD28Xht1eqsLrF, PID: 16630709
    • Belozertseva I, Kos T, Popik P, Danysz W, Bespalov A (2007) Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. Eur Neuropsychopharmacol 17:172–179
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 172-179
    • Belozertseva, I.1    Kos, T.2    Popik, P.3    Danysz, W.4    Bespalov, A.5
  • 20
    • 54049140827 scopus 로고    scopus 로고
    • The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats
    • COI: 1:CAS:528:DC%2BD1cXht12rsLnK, PID: 18838071
    • Kotlinska J, Bochenski M (2008) The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats. Eur J Pharmacol 598:57–63
    • (2008) Eur J Pharmacol , vol.598 , pp. 57-63
    • Kotlinska, J.1    Bochenski, M.2
  • 22
    • 84865832806 scopus 로고    scopus 로고
    • mGluR5 antagonist MPEP produces antidepressant effects in rats: role of brain–derived neurotrophic factor
    • COI: 1:CAS:528:DC%2BC38XhsVSnsLjO, PID: 22890078
    • Liu C, Jiang X, Zhu Y, Wei D (2012) mGluR5 antagonist MPEP produces antidepressant effects in rats: role of brain–derived neurotrophic factor. Neuroscience 223:219–224
    • (2012) Neuroscience , vol.223 , pp. 219-224
    • Liu, C.1    Jiang, X.2    Zhu, Y.3    Wei, D.4
  • 23
    • 70149088982 scopus 로고    scopus 로고
    • Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains
    • COI: 1:STN:280:DC%2BD1Mnjt12iuw%3D%3D, PID: 19376528
    • Dunham J, Deakin J, Miyajima F, Payton A, Toro C (2009) Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains. J Psychiatr Res 43:1175–1184
    • (2009) J Psychiatr Res , vol.43 , pp. 1175-1184
    • Dunham, J.1    Deakin, J.2    Miyajima, F.3    Payton, A.4    Toro, C.5
  • 24
    • 33846433505 scopus 로고    scopus 로고
    • Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper
    • PID: 17204313
    • Grønli J, Bramham C, Murison R, Kanhema T, Fiske E, Bjorvatn B, Ursin R, Portas CM (2006) Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol Biochem Behav 85:842–849
    • (2006) Pharmacol Biochem Behav , vol.85 , pp. 842-849
    • Grønli, J.1    Bramham, C.2    Murison, R.3    Kanhema, T.4    Fiske, E.5    Bjorvatn, B.6    Ursin, R.7    Portas, C.M.8
  • 25
    • 70350571134 scopus 로고    scopus 로고
    • Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells
    • COI: 1:CAS:528:DC%2BD1MXhtlylsbfO, PID: 19822193
    • Viwatpinyo K, Chongthammakun S (2009) Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells. Neurosci Lett 467:127–130
    • (2009) Neurosci Lett , vol.467 , pp. 127-130
    • Viwatpinyo, K.1    Chongthammakun, S.2
  • 26
    • 33746351511 scopus 로고    scopus 로고
    • Effect of MPEP treatment on brain-derived neurotrophic factor gene expression
    • COI: 1:CAS:528:DC%2BD28XhtVKrtbbN, PID: 16845218
    • Legutko B, Szewczyk B, Pomierny-Chamiolo L, Nowak G, Pilc A (2006) Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacol Rep 58:427
    • (2006) Pharmacol Rep , vol.58 , pp. 427
    • Legutko, B.1    Szewczyk, B.2    Pomierny-Chamiolo, L.3    Nowak, G.4    Pilc, A.5
  • 27
    • 38949115944 scopus 로고    scopus 로고
    • Mood disorders: regulation by metabotropic glutamate receptors
    • COI: 1:CAS:528:DC%2BD1cXhvVWgt7o%3D, PID: 18164691
    • Pilc A, Chaki S, Nowak G, Witkin JM (2008) Mood disorders: regulation by metabotropic glutamate receptors. Biochem Pharmacol 75:997–1006
    • (2008) Biochem Pharmacol , vol.75 , pp. 997-1006
    • Pilc, A.1    Chaki, S.2    Nowak, G.3    Witkin, J.M.4
  • 29
    • 77955424743 scopus 로고    scopus 로고
    • Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus
    • COI: 1:CAS:528:DC%2BC3cXpvFSksrw%3D, PID: 20600666
    • Iyo AH, Feyissa AM, Chandran A, Austin MC, Regunathan S, Karolewicz B (2010) Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus. Neuroscience 169:1567–1574
    • (2010) Neuroscience , vol.169 , pp. 1567-1574
    • Iyo, A.H.1    Feyissa, A.M.2    Chandran, A.3    Austin, M.C.4    Regunathan, S.5    Karolewicz, B.6
  • 30
    • 0030798541 scopus 로고    scopus 로고
    • Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus
    • COI: 1:CAS:528:DyaK2sXksFamsL4%3D, PID: 9332723
    • Kerner JA, Standaert DG, Penney JB Jr, Young AB, Landwehrmeyer GB (1997) Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus. Brain Res Mol Brain Res 48:259–269
    • (1997) Brain Res Mol Brain Res , vol.48 , pp. 259-269
    • Kerner, J.A.1    Standaert, D.G.2    Penney, J.B.3    Young, A.B.4    Landwehrmeyer, G.B.5
  • 31
    • 0032509812 scopus 로고    scopus 로고
    • Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons
    • COI: 1:CAS:528:DyaK1cXlsV2ksA%3D%3D, PID: 9507137
    • Tallaksen-Greene SJ, Kaatz KW, Romano C, Albin RL (1998) Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. Brain Res 780:210–217
    • (1998) Brain Res , vol.780 , pp. 210-217
    • Tallaksen-Greene, S.J.1    Kaatz, K.W.2    Romano, C.3    Albin, R.L.4
  • 32
    • 0032815972 scopus 로고    scopus 로고
    • Prenatal stress alters circadian activity of hypothalamo–pituitary–adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender
    • COI: 1:CAS:528:DyaK1MXlslKitL4%3D, PID: 10440731
    • Koehl M, Darnaudéry M, Dulluc J, Van Reeth O, Moal ML, Maccari S (1999) Prenatal stress alters circadian activity of hypothalamo–pituitary–adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender. J Neurobiol 40:302–315
    • (1999) J Neurobiol , vol.40 , pp. 302-315
    • Koehl, M.1    Darnaudéry, M.2    Dulluc, J.3    Van Reeth, O.4    Moal, M.L.5    Maccari, S.6
  • 33
    • 0018268297 scopus 로고
    • Behavioural despair in rats: a new model sensitive to antidepressant treatments
    • COI: 1:CAS:528:DyaE1cXhvVagsr0%3D, PID: 204499
    • Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391
    • (1978) Eur J Pharmacol , vol.47 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3    Jalfre, M.4
  • 34
    • 0019502653 scopus 로고
    • Acute and chronic stress effects on open field activity in the rat: implications for a model of depression
    • COI: 1:STN:280:DyaL3M3ntFeqtw%3D%3D, PID: 7196554
    • Katz RJ, Roth KA, Carroll BJ (1981) Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev 5:247–251
    • (1981) Neurosci Biobehav Rev , vol.5 , pp. 247-251
    • Katz, R.J.1    Roth, K.A.2    Carroll, B.J.3
  • 35
    • 84915782361 scopus 로고    scopus 로고
    • Humana Press/Springer, New York:
    • Li KW (2011) Neuroproteomics. Humana Press/Springer, New York
    • (2011) Neuroproteomics
    • Li, K.W.1
  • 36
    • 57649233611 scopus 로고    scopus 로고
    • The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor
    • PID: 18786572
    • Kapoor A, Kostaki A, Janus C, Matthews SG (2009) The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor. Behav Brain Res 197:144–149
    • (2009) Behav Brain Res , vol.197 , pp. 144-149
    • Kapoor, A.1    Kostaki, A.2    Janus, C.3    Matthews, S.G.4
  • 37
    • 76749118188 scopus 로고    scopus 로고
    • The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development
    • PID: 20331658
    • Davis EP, Sandman CA (2010) The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev 81:131–148
    • (2010) Child Dev , vol.81 , pp. 131-148
    • Davis, E.P.1    Sandman, C.A.2
  • 38
    • 33745124728 scopus 로고    scopus 로고
    • Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring
    • PID: 16598704
    • Yang J, Han H, Cao J, Li L, Xu L (2006) Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring. Hippocampus 16:431–436
    • (2006) Hippocampus , vol.16 , pp. 431-436
    • Yang, J.1    Han, H.2    Cao, J.3    Li, L.4    Xu, L.5
  • 39
    • 84874535613 scopus 로고    scopus 로고
    • Prenatal stress-induced cognitive impairment and neuronal oxidative stress and its amelioration by resveratrol in neonate rats
    • Madhyastha S, Sahu SS, Rao GM (2012) Prenatal stress-induced cognitive impairment and neuronal oxidative stress and its amelioration by resveratrol in neonate rats. Res J Pharm Biol Chem Sci 3:1387–1399
    • (2012) Res J Pharm Biol Chem Sci , vol.3 , pp. 1387-1399
    • Madhyastha, S.1    Sahu, S.S.2    Rao, G.M.3
  • 41
    • 0141887058 scopus 로고    scopus 로고
    • Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis
    • PID: 14531585
    • O’Connor TG, Heron J, Golding J, Glover V (2003) Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 44:1025–1036
    • (2003) J Child Psychol Psychiatry , vol.44 , pp. 1025-1036
    • O’Connor, T.G.1    Heron, J.2    Golding, J.3    Glover, V.4
  • 43
    • 84904552860 scopus 로고    scopus 로고
    • Prenatal restraint stress is associated with demethylation of corticotrophin releasing hormone (CRH) promoter and enhances CRH transcriptional responses to stress in adolescent rats
    • COI: 1:CAS:528:DC%2BC2cXltFeqt7o%3D, PID: 24682755
    • Xu L, Sun Y, Gao L, Cai Y-Y, Shi S-X (2014) Prenatal restraint stress is associated with demethylation of corticotrophin releasing hormone (CRH) promoter and enhances CRH transcriptional responses to stress in adolescent rats. Neurochem Res 39:1193–1198
    • (2014) Neurochem Res , vol.39 , pp. 1193-1198
    • Xu, L.1    Sun, Y.2    Gao, L.3    Cai, Y.-Y.4    Shi, S.-X.5
  • 44
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic-and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • PID: 11264235
    • Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Pałucha A, Gasparini F, Kuhn R, Pilc A (2001) Potential anxiolytic-and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol 132:1423–1430
    • (2001) Br J Pharmacol , vol.132 , pp. 1423-1430
    • Tatarczyńska, E.1    Kłodzińska, A.2    Chojnacka-Wójcik, E.3    Pałucha, A.4    Gasparini, F.5    Kuhn, R.6    Pilc, A.7
  • 45
    • 33748999574 scopus 로고    scopus 로고
    • Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice
    • COI: 1:CAS:528:DC%2BD28XhtVCksL3L, PID: 16803860
    • Li X, Need AB, Baez M, Witkin JM (2006) Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice. J Pharmacol Exp Ther 319:254–259
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 254-259
    • Li, X.1    Need, A.B.2    Baez, M.3    Witkin, J.M.4
  • 46
    • 0035695488 scopus 로고    scopus 로고
    • Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression
    • PID: 11985342
    • Szewczyk B, Ucha M, Gruca P, Moryl E (2001) Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression. Pol J Pharmacol 53:659–662
    • (2001) Pol J Pharmacol , vol.53 , pp. 659-662
    • Szewczyk, B.1    Ucha, M.2    Gruca, P.3    Moryl, E.4
  • 47
    • 77955078119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions
    • COI: 1:CAS:528:DC%2BC3cXhtFalt7vM, PID: 20653908
    • Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64:341–357
    • (2010) Psychiatry Clin Neurosci , vol.64 , pp. 341-357
    • Hashimoto, K.1
  • 48
    • 34247572536 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in the control of mood disorders
    • COI: 1:CAS:528:DC%2BD2sXltValtLc%3D, PID: 17430147
    • Witkin JM, Marek GJ, Johnson BG, Schoepp DD (2007) Metabotropic glutamate receptors in the control of mood disorders. CNS Neurol Disord Drug Targets 6:87–100
    • (2007) CNS Neurol Disord Drug Targets , vol.6 , pp. 87-100
    • Witkin, J.M.1    Marek, G.J.2    Johnson, B.G.3    Schoepp, D.D.4
  • 49
    • 34548336779 scopus 로고    scopus 로고
    • New insights into BDNF function in depression and anxiety
    • COI: 1:CAS:528:DC%2BD2sXps1Sgu7g%3D, PID: 17726474
    • Martinowich K, Manji H, Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10:1089–1093
    • (2007) Nat Neurosci , vol.10 , pp. 1089-1093
    • Martinowich, K.1    Manji, H.2    Lu, B.3
  • 50
    • 0022525601 scopus 로고
    • Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin
    • COI: 1:CAS:528:DyaL28XlslSjsbo%3D, PID: 3756525
    • Kennett GA, Chaouloff F, Marcou M, Curzon G (1986) Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain Res 382:416–421
    • (1986) Brain Res , vol.382 , pp. 416-421
    • Kennett, G.A.1    Chaouloff, F.2    Marcou, M.3    Curzon, G.4
  • 51
    • 0027424374 scopus 로고
    • Influence of gender and age on performance of rats in the elevated plus maze apparatus
    • COI: 1:STN:280:DyaK2c%2FlvFCjtA%3D%3D, PID: 8240712
    • Imhof JT, Coelho ZM, Schmitt ML, Morato GS, Carobrez AP (1993) Influence of gender and age on performance of rats in the elevated plus maze apparatus. Behav Brain Res 56:177–180
    • (1993) Behav Brain Res , vol.56 , pp. 177-180
    • Imhof, J.T.1    Coelho, Z.M.2    Schmitt, M.L.3    Morato, G.S.4    Carobrez, A.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.