Suppression of atherosclerosis by synthetic REV-ERB agonist

Biochemical and Biophysical Research Communications

Volumn 460, Issue 3, 2015, Pages 566-571

  Sitaula, Sadichha ^a   Billon, Cyrielle ^b   Kamenecka, Theodore M ^a   Solt, Laura A ^a   Burris, Thomas P ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Macrophages; Nuclear receptor; REV ERB

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; NUCLEAR RECEPTOR NR1D1; PRIMER DNA;

AGONISTS; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; GENETICS; KNOCKOUT MOUSE; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ATHEROSCLEROSIS; BASE SEQUENCE; DNA PRIMERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LDL;

EID: 84937757992     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.03.070     Document Type: Article

References (22)

1. I. Tabas Biochem. Lipids, Lipoproteins Membr 2008 579 605 10.1016/B978-044453219-0.50023-4
2. L. Kerenyi, L. Mihalka, L. Csiba, H. Bacso, and D. Bereczki Role of hyperlipidemia in atherosclerotic plaque formation in the internal carotid artery J. Clin. Ultrasound 34 2006 283 288
3. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
4. K.J. Moore, F.J. Sheedy, and E.A. Fisher Macrophages in atherosclerosis: a dynamic balance Nat. Rev. Immunol. 13 2013 709 721
5. A. Mantovani, C. Garlanda, and M. Locati Macrophage diversity and polarization in atherosclerosis: a question of balance Arterioscler. Thromb. Vasc. Biol. 29 2009 1419 1423
6. D.M. Mosser, and J.P. Edwards Exploring the full spectrum of macrophage activation Nat. Rev. Immunol. 8 2008 958 969
7. A. Mantovani The chemokine system in diverse forms of macrophage activation and polarization Trends Immunol. 25 2004 677 686
8. S. Gordon, and F.O. Martinez Alternative activation of macrophages: mechanism and functions Immunity 32 2010 593 604
9. A. Sica, and A. Mantovani Macrophage plasticity and polarization: In vivo veritas J. Clin. Invest. 122 2012 787 795
10. S.N. Ramakrishnan, and G.E.O. Muscat The orphan rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation? Nucl. Recept. Signal. 4 2006 e009
11. J.E. Gibbs The nuclear receptor REV-ERB alpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines Proc. Natl. Acad. Sci. U. S. A. 109 2012 582 587
12. H. Cho Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β Nature 485 2012 123 127
13. S. Sato Direct and indirect suppression of Interleukin-6 gene expression in Murine macrophages by nuclear orphan receptor REV-erbα Sci. World J. 2014 2014 685854
14. S. Sato A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression J. Immunol. 192 2014 407 417
15. H. Ma Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down J. Am. Heart Assoc. 2 2013 e000235
16. S. Banerjee Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour Nat. Commun. 5 2014
17. S. Raghuram Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta Nat. Struct. Mol. Biol. 14 2007 1207 1213
18. L.A. Solt Regulation of circadian behavior and metabolism by synthetic REV-erb agonists Nature 485 2012 62 68
19. D.E. Amacher Serum transaminase elevations as indicators of hepatic injury following the administration of drugs Regul. Toxicol. Pharmacol. 27 1998 119 130
20. J. Delezie The nuclear receptor REV-ERB is required for the daily balance of carbohydrate and lipid metabolism FASEB J. 26 2012 3321 3335
21. J.A. Ripperger, and U. Albrecht REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology Cell. Res. 22 2012 1319 1321
22. A. Bugge Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function Genes. Dev. 26 2012 657 667