Induction of interleukin-1β by human immunodeficiency virus-1 viral proteins leads to increased levels of neuronal ferritin heavy chain, synaptic injury, and deficits in flexible attention

Journal of Neuroscience

Volumn 35, Issue 29, 2015, Pages 10550-10561

  Festa, Lindsay ^a   Gutoskey, Christopher J ^a   Graziano, Alessandro ^a   Waterhouse, Barry D ^a   Meucci, Olimpia ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Chemokine; Cytokine; Dendritic spine; gp120; HAND; HIV cognitive impairment

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; FERRITIN HEAVY CHAIN; GLYCOPROTEIN GP 120; INTERLEUKIN 1BETA; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUTRALIZING ANTIBODY; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN; APOFERRITIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN CELL CULTURE; CONTROLLED STUDY; DENDRITE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIV ASSOCIATED DEMENTIA; IMMUNOBLOTTING; LEARNING; MALE; NERVOUS SYSTEM INJURY; NERVOUS SYSTEM PARAMETERS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN ISOLATION; PYRAMIDAL NERVE CELL; RAT; SPINE DENSITY; STEREOTACTIC PROCEDURE; SYNAPTIC INJURY; UPREGULATION; WESTERN BLOTTING; ANIMAL; BRAIN; DISEASE MODEL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PATHOLOGY; TRANSGENIC RAT;

AIDS DEMENTIA COMPLEX; ANIMALS; APOFERRITINS; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV-1; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; NEURONS; RATS; RATS, TRANSGENIC; VIRAL PROTEINS;

EID: 84937700943     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4403-14.2015     Document Type: Article

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