Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat

Journal of Neuroimmunology

Volumn 247, Issue 1-2, 2012, Pages 16-24

  Royal, Walter ^a,b   Zhang, Li ^a   Guo, Ming ^a   Jones, Odell ^a   Davis, Harry ^a   Bryant, Joseph L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b The Veterans Health Administration Multiple Sclerosis Center of Excellence East   (United States)

Author keywords

Brain; HIV; Neurotoxicity; Proinflammatory cytokines; Spleen; Transgenic rat

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 160; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; NEF PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VIF PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE PRODUCT; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE ACTIVATION; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; LYMPHOCYTE ACTIVATION; MACROPHAGE; MICROGLIA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC RAT; VIRUS GENE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; BRAIN; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, VIRAL; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; NEUROTOXICITY SYNDROMES; RATS; RATS, TRANSGENIC; SIGNAL TRANSDUCTION; TIME FACTORS; VIRAL PROTEINS;

EID: 84860840056     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.03.015     Document Type: Article

References (41)

1. Adamson D.C., Wildemann B., Sasaki M., Glass J.D., McArthur J.C., Christov V.I., Dawson T.M., Dawson V.L. Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996, 274:1917-1921.
2. Basselin M., Ramadan E., Igarashi M., Chang L., Chen M., Kraft A.D., Harry G.J., Rapoport S.I. Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. J. Cereb. Blood Flow Metab. 2011, 31:486-493.
3. Boisse L., Gill M.J., Power C. HIV infection of the central nervous system: clinical features and neuropathogenesis. Neurol. Clin. 2008, 26:799-819. x.
4. Braathen L.R. Langerhans cells and HIV infection. Biomed. Pharmacother. 1988, 42:305-308.
5. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 1999, 13:1-22.
6. Bruce-Keller A.J., Turchan-Cholewo J., Smart E.J., Geurin T., Chauhan A., Reid R., Xu R., Nath A., Knapp P.E., Hauser K.F. Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV-1 Tat transgenic mice. Glia 2008, 56:1414-1427.
7. Cargnello M., Roux P.P. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol. Mol. Biol. Rev. 2011, 75:50-83.
8. Cassol E., Cassetta L., Alfano M., Poli G. Macrophage polarization and HIV-1 infection. J. Leukoc. Biol. 2010, 87:599-608.
9. Cavanaugh J.E., Ham J., Hetman M., Poser S., Yan C., Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J. Neurosci. 2001, 21:434-443.
10. Dawson T.M., Dawson V.L. gp120 neurotoxicity in primary cortical cultures. Adv. Neuroimmunol. 1994, 4:167-173.
11. Debrick J.E., Campbell P.A., Staerz U.D. Macrophages as accessory cells for class I MHC-restricted immune responses. J. Immunol. 1991, 147:2846-2851.
12. Dickie P., Felser J., Eckhaus M., Bryant J., Silver J., Marinos N., Notkins A.L. HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology 1991, 185:109-119.
13. Dou H., Morehead J., Bradley J., Gorantla S., Ellison B., Kingsley J., Smith L.M., Chao W., Bentsman G., Volsky D.J., Gendelman H.E. Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brain. Glia 2006, 54:81-93.
14. Dreyer E.B., Kaiser P.K., Offermann J.T., Lipton S.A. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990, 248:364-367.
15. Glass J.D., Fedor H., Wesselingh S.L., McArthur J.C. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol. 1995, 38:755-762.
16. Gorantla S., Sneller H., Walters L., Sharp J.G., Pirruccello S.J., West J.T., Wood C., Dewhurst S., Gendelman H.E., Poluektova L. Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J. Virol. 2007, 81:2700-2712.
17. June H.L., Tzeng Yang A.R., Bryant J.L., Jones O., Royal W. Vitamin A deficiency and behavioral and motor deficits in the human immunodeficiency virus type 1 transgenic rat. J. Neurovirol. 2009, 15:380-389.
18. Kaul M., Lipton S.A. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: chemokine receptors, excitotoxicity, and beyond. J. Neurovirol. 2004, 10(Suppl. 1):97-101.
19. Kim B.O., Liu Y., Ruan Y., Xu Z.C., Schantz L., He J.J. Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am. J. Pathol. 2003, 162:1693-1707.
20. Kraft-Terry S.D., Stothert A.R., Buch S., Gendelman H.E. HIV-1 neuroimmunity in the era of antiretroviral therapy. Neurobiol. Dis. 2010, 37:542-548.
21. Kramer-Hammerle S., Rothenaigner I., Wolff H., Bell J.E., Brack-Werner R. Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus. Virus Res. 2005, 111:194-213.
22. Kruman I.I., Nath A., Mattson M.P. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp. Neurol. 1998, 154:276-288.
23. Lindzen E., Jewells V., Bouldin T., Speer D., Royal W., Markovic-Plese S. Progressive tumefactive inflammatory central nervous system demyelinating disease in an acquired immunodeficiency syndrome patient treated with highly active antiretroviral therapy. J. Neurovirol. 2008, 14:569-573.
24. Liu X., Chang L., Vigorito M., Kass M., Li H., Chang S.L. Methamphetamine-induced behavioral sensitization is enhanced in the HIV-1 transgenic rat. J. Neuroimmune. Pharmacol. 2009, 4:309-316.
25. Mazzucchelli R., Amadio M., Curreli S., Denaro F., Bemis K., Reid W., Bryant J., Riva A., Galli M., Zella D. Establishment of an ex vivo model of monocytes-derived macrophages differentiated from peripheral blood mononuclear cells (PBMCs) from HIV-1 transgenic rats. Mol. Immunol. 2004, 41:979-984.
26. Meltzer M.S., Skillman D.R., Gomatos P.J., Kalter D.C., Gendelman H.E. Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. Annu. Rev. Immunol. 1990, 8:169-194.
27. Molina J.M., Schindler R., Ferriani R., Sakaguchi M., Vannier E., Dinarello C.A., Groopman J.E. Production of cytokines by peripheral blood monocytes/macrophages infected with human immunodeficiency virus type 1 (HIV-1). J. Infect. Dis. 1990, 161:888-893.
28. Obara Y., Nakahata N. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77:10-16.
29. Peng J., Vigorito M., Liu X., Zhou D., Wu X., Chang S.L. The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART. J. Neuroimmunol. 2010, 218:94-101.
30. Reid W., Sadowska M., Denaro F., Rao S., Foulke J., Hayes N., Jones O., Doodnauth D., Davis H., Sill A., O'Driscoll P., Huso D., Fouts T., Lewis G., Hill M., Kamin-Lewis R., Wei C., Ray P., Gallo R.C., Reitz M., Bryant J. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:9271-9276.
31. Robbins D.S., Shirazi Y., Drysdale B.E., Lieberman A., Shin H.S., Shin M.L. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J. Immunol. 1987, 139:2593-2597.
32. Roy S., Fitz-Gibbon L., Poulin L., Wainberg M.A. Infection of human monocytes/macrophages by HIV-1: effect on secretion of IL-1 activity. Immunology 1988, 64:233-239.
33. Royal W., Wang H., Jones O., Tran H., Bryant J.L. A vitamin A deficient diet enhances proinflammatory cytokine, Mu opioid receptor, and HIV-1 expression in the HIV-1 transgenic rat. J. Neuroimmunol. 2007, 185:29-36.
34. Sultana S., Li H., Puche A., Jones O., Bryant J.L., Royal W. Quantitation of parvalbumin+ neurons and human immunodeficiency virus type 1 (HIV-1) regulatory gene expression in the HIV-1 transgenic rat: effects of vitamin A deficiency and morphine. J. Neurovirol. 2010, 16:33-40.
35. Trujillo J.R., McLane M.F., Lee T.H., Essex M. Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins. J. Virol. 1993, 67:7711-7715.
36. Tyor W.R., Glass J.D., Griffin J.W., Becker P.S., McArthur J.C., Bezman L., Griffin D.E. Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 1992, 31:349-360.
37. Tyor W.R., Power C., Gendelman H.E., Markham R.B. A model of human immunodeficiency virus encephalitis in scid mice. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:8658-8662.
38. Webb K.M., Aksenov M.Y., Mactutus C.F., Booze R.M. Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat. J. Neurovirol. 2010, 16:168-173.
39. Wong G.H., Bartlett P.F., Clark-Lewis I., Battye F., Schrader J.W. Inducible expression of H-2 and Ia antigens on brain cells. Nature 1984, 310:688-691.
40. Yadav A., Collman R.G. CNS inflammation and macrophage/microglial biology associated with HIV-1 infection. J. Neuroimmune. Pharmacol. 2009, 4:430-447.
41. Zeinstra E., Wilczak N., Streefland C., De Keyser J. Astrocytes in chronic active multiple sclerosis plaques express MHC class II molecules. Neuroreport 2000, 11:89-91.