Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury

Cell Reports

Volumn 11, Issue 11, 2015, Pages 1679-1685

  Braun, Simon M G ^a,c   Pilz, Gregor Alexander ^a   Machado, Raquel A C ^a   Moss, Jonathan ^b   Becher, Burkhard ^a   Toni, Nicolas ^b   Jessberger, Sebastian ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; MYELIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR SOX10; ASCL1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL MATURATION; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; GENETIC MODEL; GLIA CELL; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; MOUSE MODEL; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REMYELINIZATION; ANIMAL; C57BL MOUSE; CYTOLOGY; DEMYELINATING DISEASES; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MYELIN SHEATH; PATHOLOGY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN INJURIES; DEMYELINATING DISEASES; DIPHTHERIA TOXIN; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MYELIN SHEATH; NEURAL STEM CELLS; NEUROGENESIS;

EID: 84937637820     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.05.024     Document Type: Article

References (31)

1. Benedict R.H.B., Ramasamy D., Munschauer F., Weinstock-Guttman B., Zivadinov R. Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy. J. Neurol. Neurosurg. Psychiatry 2009, 80:201-206.
2. Bracko O., Singer T., Aigner S., Knobloch M., Winner B., Ray J., Clemenson G.D., Suh H., Couillard-Despres S., Aigner L., et al. Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J. Neurosci. 2012, 32:3376-3387.
3. Buch T., Heppner F.L., Tertilt C., Heinen T.J.A.J., Kremer M., Wunderlich F.T., Jung S., Waisman A. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat. Methods 2005, 2:419-426.
4. Chambers J.S., Perrone-Bizzozero N.I. Altered myelination of the hippocampal formation in subjects with schizophrenia and bipolar disorder. Neurochem. Res. 2004, 29:2293-2302.
5. Chiaravalloti N.D., DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 2008, 7:1139-1151.
6. Deverman B.E., Patterson P.H. Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination. J. Neurosci. 2012, 32:2100-2109.
7. Franklin R.J.M., Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 2008, 9:839-855.
8. Gage F.H. Mammalian neural stem cells. Science 2000, 287:1433-1438.
9. Geurts J.J.G., Bö L., Roosendaal S.D., Hazes T., Daniëls R., Barkhof F., Witter M.P., Huitinga I., van der Valk P. Extensive hippocampal demyelination in multiple sclerosis. J. Neuropathol. Exp. Neurol. 2007, 66:819-827.
10. Goldman S.A., Natesan S. A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus. Cell Stem Cell 2008, 3:125-126.
11. Hemanth Kumar B.S., Mishra S.K., Trivedi R., Singh S., Rana P., Khushu S. Demyelinating evidences in CMS rat model of depression: a DTI study at 7 T. Neuroscience 2014, 275:12-21.
12. Huang J.K., Jarjour A.A., Nait Oumesmar B., Kerninon C., Williams A., Krezel W., Kagechika H., Bauer J., Zhao C., Baron-Van Evercooren A., et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat. Neurosci. 2011, 14:45-53.
13. Jessberger S., Gage F.H. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol. Sci. 2009, 30:61-65.
14. Jessberger S., Toni N., Clemenson G.D., Ray J., Gage F.H. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat. Neurosci. 2008, 11:888-893.
15. Knobloch M., Braun S.M.G., Zurkirchen L., von Schoultz C., Zamboni N., Araúzo-Bravo M.J., Kovacs W.J., Karalay O., Suter U., Machado R.A., et al. Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature 2013, 493:226-230.
16. Küspert M., Hammer A., Bösl M.R., Wegner M. Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Res. 2011, 39:1280-1293.
17. Lindvall O., Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006, 441:1094-1096.
18. Locatelli G., Wörtge S., Buch T., Ingold B., Frommer F., Sobottka B., Krüger M., Karram K., Bühlmann C., Bechmann I., et al. Primary oligodendrocyte death does not elicit anti-CNS immunity. Nat. Neurosci. 2012, 15:543-550.
19. Meier S., Bräuer A.U., Heimrich B., Nitsch R., Savaskan N.E. Myelination in the hippocampus during development and following lesion. Cell. Mol. Life Sci. 2004, 61:1082-1094.
20. Menn B., Garcia-Verdugo J.M., Yaschine C., Gonzalez-Perez O., Rowitch D., Alvarez-Buylla A. Origin of oligodendrocytes in the subventricular zone of the adult brain. J. Neurosci. 2006, 26:7907-7918.
21. Nakatani H., Martin E., Hassani H., Clavairoly A., Maire C.L., Viadieu A., Kerninon C., Delmasure A., Frah M., Weber M., et al. Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination. J. Neurosci. 2013, 33:9752-9768.
22. Noble M. The possible role of myelin destruction as a precipitating event in Alzheimer's disease. Neurobiol. Aging 2004, 25:25-31.
23. Petryniak M.A., Potter G.B., Rowitch D.H., Rubenstein J.L.R. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron 2007, 55:417-433.
24. Picard-Riera N., Decker L., Delarasse C., Goude K., Nait-Oumesmar B., Liblau R., Pham-Dinh D., Baron-Van Evercooren A. Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc. Natl. Acad. Sci. USA 2002, 99:13211-13216.
25. Pohl H.B.F., Porcheri C., Mueggler T., Bachmann L.C., Martino G., Riethmacher D., Franklin R.J.M., Rudin M., Suter U. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J. Neurosci. 2011, 31:1069-1080.
26. Rafalski V.A., Ho P.P., Brett J.O., Ucar D., Dugas J.C., Pollina E.A., Chow L.M.L., Ibrahim A., Baker S.J., Barres B.A., et al. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain. Nat. Cell Biol. 2013, 15:614-624.
27. Stolt C.C., Rehberg S., Ader M., Lommes P., Riethmacher D., Schachner M., Bartsch U., Wegner M. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 2002, 16:165-170.
28. Yang H.-J., Wang H., Zhang Y., Xiao L., Clough R.W., Browning R., Li X.-M., Xu H. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia. Brain Res. 2009, 1270:121-130.
29. Yang N., Zuchero J.B., Ahlenius H., Marro S., Ng Y.H., Vierbuchen T., Hawkins J.S., Geissler R., Barres B.A., Wernig M. Generation of oligodendroglial cells by direct lineage conversion. Nat. Biotechnol. 2013, 31:434-439.
30. Zhao C., Teng E.M., Summers R.G., Ming G.-L., Gage F.H. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J. Neurosci. 2006, 26:3-11.
31. Zhou Q., Anderson D.J. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 2002, 109:61-73.