Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation

Biochemical and Biophysical Research Communications

Volumn 464, Issue 1, 2015, Pages 20-26

  Lee, Eun Jung ^a   Kim, Jun Won ^a   Yoo, Hyun ^a   Kwak, Woori ^b   Choi, Won Hoon ^a   Cho, Seoae ^b   Choi, Yu Jeong ^a   Lee, Yoon Jin ^c   Cho, Jaeho ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Eosinophil mediated fibrosis; Interleukin 33; Radiotherapy; Skin injury

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHA5 INTEGRIN; CHEMOKINE RECEPTOR CXCR2; COLLAGEN; COMPLEMENT COMPONENT C5; EOTAXIN; INTERLEUKIN 1; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; PADGEM PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ANTIBODY; INTERLEUKIN DERIVATIVE; INTERLEUKIN-33, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CAPILLARY DENSITY; CELL ADHESION; CELL MIGRATION; CHEMOTAXIS; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA DAMAGE; ENDOTHELIUM CELL; EOSINOPHIL; EPIDERMIS HYPERPLASIA; EXPERIMENTAL PIG; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAST CELL; MINIPIG; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; SKIN BLOOD VESSEL; SKIN FIBROSIS; SKIN INJURY; TH2 CELL; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY; PIG; RADIATION RESPONSE; SECRETION (PROCESS); SKIN; VASCULARIZATION; X RAY;

SUIDAE; SUS;

ANIMALS; ANTIBODIES; CELL MOVEMENT; CHEMOKINE CCL11; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, RADIATION; EOSINOPHILS; FEMALE; FIBROSIS; GENE EXPRESSION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-4; INTERLEUKIN-5; INTERLEUKINS; MACROPHAGES; MICE; RADIATION DOSAGE; SKIN; SWINE; TRANSFORMING GROWTH FACTOR BETA; X-RAYS;

EID: 84937637204     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.081     Document Type: Article

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