Factors secreted from dental pulp stem cells show multifaceted benefits for treating acute lung injury in mice

Cytotherapy

Volumn 17, Issue 8, 2015, Pages 1119-1129

  Wakayama, Hirotaka ^a   Hashimoto, Naozumi ^a   Matsushita, Yoshihiro ^a   Matsubara, Kohki ^a   Yamamoto, Noriyuki ^a   Hasegawa, Yoshinori ^a   Ueda, Minoru ^a   Yamamoto, Akihito ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Conditioned medium; Dental pulp stem cells; Inflammation; Macrophages; Respiratory distress syndrome

Indexed keywords

ARGINASE 1; CD206 PROTEIN; CELL MARKER; UNCLASSIFIED DRUG; YM 1 PROTEIN; ARGINASE; ARGINASE I, HUMAN; BLEOMYCIN; CELL SURFACE RECEPTOR; CULTURE MEDIUM; CYTOKINE; LECTIN; MANNOSE BINDING LECTIN; MANNOSE RECEPTOR;

ACUTE LUNG INJURY; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARGINASE 1 GENE; ARTICLE; BONE MARROW; CD206 GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; DECIDUOUS TOOTH; DENTAL PULP STEM CELL; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; MARKER GENE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; SURVIVAL RATE; TISSUE REGENERATION; WEIGHT REDUCTION; YM 1 GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; LUNG; MACROPHAGE; METABOLISM; PATHOLOGY; PHARMACOLOGY; PHYSIOLOGY; REGENERATION; RESPIRATORY DISTRESS SYNDROME, ADULT; SECRETION (PROCESS); STEM CELL TRANSPLANTATION; TOOTH PULP;

MUS;

ACUTE LUNG INJURY; ANIMALS; ARGINASE; BLEOMYCIN; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DENTAL PULP; FEMALE; HUMANS; LECTINS, C-TYPE; LUNG; MACROPHAGES; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; REGENERATION; RESPIRATORY DISTRESS SYNDROME, ADULT; STEM CELL TRANSPLANTATION; TOOTH, DECIDUOUS;

EID: 84937632810     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2015.04.009     Document Type: Article

References (45)

1. Wheeler A.P., Bernard G.R. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 2007, 369:1553-1564.
2. Matthay M.A., Ware L.B., Zimmerman G.A. The acute respiratory distress syndrome. J Clin Invest 2012, 122:2731-2740.
3. Herold S., Gabrielli N.M., Vadasz I. Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2013, 305:L665-L681.
4. Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011, 11:723-737.
5. Mantovani A., Biswas S.K., Galdiero M.R., Sica A., Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013, 229:176-185.
6. Murray P.J., Allen J.E., Biswas S.K., Fisher E.A., Gilroy D.W., Goerdt S., et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 2014, 41:14-20.
7. Wynn T.A., Ramalingam T.R. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 2012, 18:1028-1040.
8. Sueblinvong V., Weiss D.J. Stem cells and cell therapy approaches in lung biology and diseases. Transl Res 2010, 156:188-205.
9. Ortiz L.A., Gambelli F., McBride C., Gaupp D., Baddoo M., Kaminski N., et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003, 100:8407-8411.
10. Rojas M., Xu J., Woods C.R., Mora A.L., Spears W., Roman J., et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005, 33:145-152.
11. Saito S., Nakayama T., Hashimoto N., Miyata Y., Egashira K., Nakao N., et al. Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage. Am J Pathol 2011, 179:1088-1094.
12. Moodley Y., Atienza D., Manuelpillai U., Samuel C.S., Tchongue J., Ilancheran S., et al. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol 2009, 175:303-313.
13. Cargnoni A., Gibelli L., Tosini A., Signoroni P.B., Nassuato C., Arienti D., et al. Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis. Cell Transplant 2009, 18:405-422.
14. Moodley Y., Ilancheran S., Samuel C., Vaghjiani V., Atienza D., Williams E.D., et al. Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med 2010, 182:643-651.
15. Murphy S., Lim R., Dickinson H., Acharya R., Rosli S., Jenkin G., et al. Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function. Cell Transplant 2011, 20:909-923.
16. Ranganath S.H., Levy O., Inamdar M.S., Karp J.M. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012, 10:244-258.
17. Cargnoni A., Ressel L., Rossi D., Poli A., Arienti D., Lombardi G., et al. Conditioned medium from amniotic mesenchymal tissue cells reduces progression of bleomycin-induced lung fibrosis. Cytotherapy 2012, 14:153-161.
18. Gronthos S., Mankani M., Brahim J., Robey P.G., Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000, 97:13625-13630.
19. Miura M., Gronthos S., Zhao M., Lu B., Fisher L.W., Robey P.G., et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003, 100:5807-5812.
20. Sakai K., Yamamoto A., Matsubara K., Nakamura S., Naruse M., Yamagata M., et al. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. J Clin Invest 2012, 122:80-90.
21. Inoue T., Sugiyama M., Hattori H., Wakita H., Wakabayashi T., Ueda M. Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats. Tissue Eng Part A 2013, 19:24-29.
22. Gandia C., Arminan A., Garcia-Verdugo J.M., Lledo E., Ruiz A., Minana M.D., et al. Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells 2008, 26:638-645.
23. Nakashima M., Iohara K., Sugiyama M. Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration. Cytokine Growth Factor Rev 2009, 20:435-440.
24. Yamaza T., Kentaro A., Chen C., Liu Y., Shi Y., Gronthos S., et al. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther 2010, 1:5.
25. Yamagata M., Yamamoto A., Kako E., Kaneko N., Matsubara K., Sakai K., et al. Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke 2013, 44:551-554.
26. Yamamoto A., Sakai K., Matsubara K., Kano F., Ueda M. Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury. Neurosci Res 2014, 78:16-20.
27. Hashimoto N., Jin H., Liu T., Chensue S.W., Phan S.H. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004, 113:243-252.
28. Sakamoto K., Hashimoto N., Kondoh Y., Imaizumi K., Aoyama D., Kohnoh T., et al. Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. Am J Physiol Lung Cell Mol Physiol 2012, 303:L43-53.
29. Ashcroft T., Simpson J.M., Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988, 41:467-470.
30. Ando Y., Matsubara K., Ishikawa J., Fujio M., Shohara R., Hibi H., et al. Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms. Bone 2014, 61:82-90.
31. McWhorter F.Y., Wang T., Nguyen P., Chung T., Liu W.F. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A 2013, 110:17253-17258.
32. Matsubara K., Matsushita Y., Sakai K., Kano F., Kondo M., Noda M., et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci 2015, 35:2452-2464.
33. Ware L.B., Matthay M.A. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol 2002, 282:L924-L940.
34. Aoki F., Kurabayashi M., Hasegawa Y., Kojima I. Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. Am J Respir Crit Care Med 2005, 172:713-720.
35. Akhmetshina A., Palumbo K., Dees C., Bergmann C., Venalis P., Zerr P., et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun 2012, 3:735.
36. Crestani B., Marchand-Adam S., Quesnel C., Plantier L., Borensztajn K., Marchal J., et al. Hepatocyte growth factor and lung fibrosis. Proc Am Thorac Soc 2012, 9:158-163.
37. Ortiz L.A., Dutreil M., Fattman C., Pandey A.C., Torres G., Go K., et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A 2007, 104:11002-11007.
38. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
39. Roca H., Varsos Z.S., Sud S., Craig M.J., Ying C., Pienta K.J. CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem 2009, 284:34342-34354.
40. Ionescu L., Byrne R.N., van Haaften T., Vadivel A., Alphonse R.S., Rey-Parra G.J., et al. Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol 2012, 303:L967-L977.
41. Chen F., Liu Z., Wu W., Rozo C., Bowdridge S., Millman A., et al. An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med 2012, 18:260-266.
42. Sugahara K., Iyama K., Kuroda M.J., Sano K. Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats. J Pathol 1998, 186:90-98.
43. Mizuno S., Matsumoto K., Li M.Y., Nakamura T. HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. FASEB J 2005, 19:580-582.
44. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3:23-35.
45. Martinez-Pomares L. The mannose receptor. J Leukoc Biol 2012, 92:1177-1186.