Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage

American Journal of Pathology

Volumn 179, Issue 3, 2011, Pages 1088-1094

  Saito, Shigeki ^a   Nakayama, Takayuki ^a   Hashimoto, Naozumi ^a   Miyata, Yasuhiko ^b   Egashira, Kensuke ^c   Nakao, Norihiko ^a   Nishiwaki, Satoshi ^a   Hasegawa, Minoru ^d   Hasegawa, Yoshinori ^a   Naoe, Tomoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7ND; BLEOMYCIN; CHEMOKINE RECEPTOR ANTAGONIST; LENTIVIRUS VECTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATORY CELL; LENTIVIRINAE; LUNG INJURY; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRAL GENE DELIVERY SYSTEM; WEIGHT REDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CHEMOKINE CCL2; GENE THERAPY; GENETIC VECTORS; HUMANS; LENTIVIRUS; LUNG INJURY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; RESPIRATORY DISTRESS SYNDROME, ADULT; TRANSDUCTION, GENETIC;

EID: 80052833354     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.05.027     Document Type: Article

References (33)

1. L.B. Ware, and M.A. Matthay The acute respiratory distress syndrome N Engl J Med 342 2000 1334 1349 (Pubitemid 30408719)
2. P.R. Rocco, E.M. Negri, P.M. Kurtz, F.P. Vasconcellos, G.H. Silva, V.L. Capelozzi, P.V. Romero, and W.A. Zin Lung tissue mechanics and extracellular matrix remodeling in acute lung injury Am J Respir Crit Care Med 164 2001 1067 1071 (Pubitemid 32971660)
3. G.U. Meduri Late adult respiratory distress syndrome New Horiz 1 1993 563 577
4. L.A. Ortiz, F. Gambelli, C. McBride, D. Gaupp, M. Baddoo, N. Kaminski, and D.G. Phinney Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects Proc Natl Acad Sci U S A 100 2003 8407 8411 (Pubitemid 36842558)
5. M. Rojas, J. Xu, C.R. Woods, A.L. Mora, W. Spears, J. Roman, and K.L. Brigham Bone marrow-derived mesenchymal stem cells in repair of the injured lung Am J Respir Cell Mol Biol 33 2005 145 152 (Pubitemid 41473051)
6. S.L. Deshmane, S. Kremlev, S. Amini, and B.E. Sawaya Monocyte chemoattractant protein-1 (MCP-1): an overview J Interferon Cytokine Res 29 2009 313 326
7. S. Rosseau, P. Hammerl, U. Maus, H.D. Walmrath, H. Schutte, F. Grimminger, W. Seeger, and J. Lohmeyer Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome Am J Physiol Lung Cell Mol Physiol 279 2000 L25 L35
8. R.B. Goodman, R.M. Strieter, D.P. Martin, K.P. Steinberg, J.A. Milberg, R.J. Maunder, S.L. Kunkel, A. Walz, L.D. Hudson, and T.R. Martin Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome Am J Respir Crit Care Med 154 1996 602 611 (Pubitemid 26327279)
9. W.C. Lin, C.F. Lin, C.L. Chen, C.W. Chen, and Y.S. Lin Prediction of outcome in patients with acute respiratory distress syndrome by bronchoalveolar lavage inflammatory mediators Exp Biol Med (Maywood) 235 2010 57 65
10. B.B. Moore, R. Paine III, P.J. Christensen, T.A. Moore, S. Sitterding, R. Ngan, C.A. Wilke, W.A. Kuziel, and G.B. Toews Protection from pulmonary fibrosis in the absence of CCR2 signaling J Immunol 167 2001 4368 4377 (Pubitemid 32954313)
11. B.B. Moore, J.E. Kolodsick, V.J. Thannickal, K. Cooke, T.A. Moore, C. Hogaboam, C.A. Wilke, and G.B. Toews CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury Am J Pathol 166 2005 675 684 (Pubitemid 40315625)
12. M. Gharaee-Kermani, R.E. McCullumsmith, I.F. Charo, S.L. Kunkel, and S.H. Phan CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis Cytokine 24 2003 266 276 (Pubitemid 37373662)
13. Y.J. Zhang, B.J. Rutledge, and B.J. Rollins Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis: identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis J Biol Chem 269 1994 15918 15924
14. Y. Zhang, and B.J. Rollins A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer Mol Cell Biol 15 1995 4851 4855
15. N. Nakao, T. Nakayama, T. Yahata, Y. Muguruma, S. Saito, Y. Miyata, K. Yamamoto, and T. Naoe Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells Am J Pathol 177 2010 547 554
16. H. Shimizu, S. Maruyama, Y. Yuzawa, T. Kato, Y. Miki, S. Suzuki, W. Sato, Y. Morita, H. Maruyama, K. Egashira, and S. Matsuo Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria J Am Soc Nephrol 14 2003 1496 1505 (Pubitemid 36687051)
17. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147 (Pubitemid 29282067)
18. J. Kanellis, R. Bick, G. Garcia, L. Truong, C.C. Tsao, D. Etemadmoghadam, B. Poindexter, L. Feng, R.J. Johnson, and D. Sheikh-Hamad Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis Am J Physiol Renal Physiol 286 2004 F356 F362
19. N. Hashimoto, H. Jin, T. Liu, S.W. Chensue, and S.H. Phan Bone marrow-derived progenitor cells in pulmonary fibrosis J Clin Invest 113 2004 243 252 (Pubitemid 38544209)
20. T. Ashcroft, J.M. Simpson, and V. Timbrell Simple method of estimating severity of pulmonary fibrosis on a numerical scale J Clin Pathol 41 1988 467 470 (Pubitemid 18098428)
21. L.S. van Rijt, H. Kuipers, N. Vos, D. Hijdra, H.C. Hoogsteden, and B.N. Lambrecht A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma J Immunol Methods 288 2004 111 121 (Pubitemid 38739257)
22. B.B. Moore, and C.M. Hogaboam Murine models of pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol 294 2008 L152 L160
23. J. Reiser, G. Harmison, S. Kluepfel-Stahl, R.O. Brady, S. Karlsson, and M. Schubert Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles Proc Natl Acad Sci U S A 93 1996 15266 15271
24. I.F. Charo, and R.M. Ransohoff The many roles of chemokines and chemokine receptors in inflammation N Engl J Med 354 2006 610 621 (Pubitemid 43209108)
25. J. Tolar, A.J. Nauta, M.J. Osborn, A. Panoskaltsis Mortari, R.T. McElmurry, S. Bell, L. Xia, N. Zhou, M. Riddle, T.M. Schroeder, J.J. Westendorf, R.S. McIvor, P.C. Hogendoorn, K. Szuhai, L. Oseth, B. Hirsch, S.R. Yant, M.A. Kay, A. Peister, D.J. Prockop, W.E. Fibbe, and B.R. Blazar Sarcoma derived from cultured mesenchymal stem cells Stem Cells 25 2007 371 379 (Pubitemid 46232791)
26. L.A. Ortiz, M. Dutreil, C. Fattman, A.C. Pandey, G. Torres, K. Go, and D.G. Phinney Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury Proc Natl Acad Sci U S A 104 2007 11002 11007 (Pubitemid 47175216)
27. S.H. Lee, A.S. Jang, Y.E. Kim, J.Y. Cha, T.H. Kim, S. Jung, S.K. Park, Y.K. Lee, J.H. Won, Y.H. Kim, and C.S. Park Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis Respir Res 11 2010 16
28. T. Okuma, Y. Terasaki, K. Kaikita, H. Kobayashi, W.A. Kuziel, M. Kawasuji, and M. Takeya C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases J Pathol 204 2004 594 604 (Pubitemid 39585959)
29. C.P. Baran, J.M. Opalek, S. McMaken, C.A. Newland, J.M. O'Brien Jr, M.G. Hunter, B.D. Bringardner, M.M. Monick, D.R. Brigstock, P.C. Stromberg, G.W. Hunninghake, and C.B. Marsh Important roles for macrophage colony-stimulating factor CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis Am J Respir Crit Care Med 176 2007 78 89 (Pubitemid 47048057)
30. K. Zhang, M. Gharaee-Kermani, B. McGarry, D. Remick, and S.H. Phan TNF-α-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis J Immunol 158 1997 954 959 (Pubitemid 127492676)
31. I. Inoshima, K. Kuwano, N. Hamada, N. Hagimoto, M. Yoshimi, T. Maeyama, A. Takeshita, S. Kitamoto, K. Egashira, and N. Hara Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice Am J Physiol Lung Cell Mol Physiol 286 2004 L1038 L1044
32. J. Phua, J.R. Badia, N.K. Adhikari, J.O. Friedrich, R.A. Fowler, J.M. Singh, D.C. Scales, D.R. Stather, A. Li, A. Jones, D.J. Gattas, D. Hallett, G. Tomlinson, T.E. Stewart, and N.D. Ferguson Has mortality from acute respiratory distress syndrome decreased over time? a systematic review Am J Respir Crit Care Med 179 2009 220 227
33. S.E. Erickson, G.S. Martin, J.L. Davis, M.A. Matthay, and M.D. Eisner Recent trends in acute lung injury mortality: 19962005 Crit Care Med 37 2009 1574 1579