Does physical activity protect against drug abuse vulnerability?

Drug and Alcohol Dependence

Volumn 153, Issue , 2015, Pages 3-13

  Bardo, Michael T ^a   Compton, Wilson M ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Drug abuse; Drug reward; Exercise; Impulsivity; Physical activity; Stress

Indexed keywords

BRAIN DEVELOPMENT; CAUDATE NUCLEUS; DECISION MAKING; DRINKING BEHAVIOR; DRUG ABUSE; EXECUTIVE FUNCTION; HUMAN; IMPULSIVENESS; MEDIAL PREFRONTAL CORTEX; NONHUMAN; PHYSICAL ACTIVITY; PLACE PREFERENCE; PRIORITY JOURNAL; RELAPSE; REVIEW; REWARD; RISK ASSESSMENT; VULNERABLE POPULATION; ANIMAL; CLINICAL TRIAL (TOPIC); METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; PREFRONTAL CORTEX; PROCEDURES; SUBSTANCE-RELATED DISORDERS;

NICOTIANA TABACUM;

ANIMALS; CLINICAL TRIALS AS TOPIC; HUMANS; MOTOR ACTIVITY; PREFRONTAL CORTEX; SUBSTANCE-RELATED DISORDERS;

EID: 84937630993     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2015.05.037     Document Type: Review

References (170)

1. Abrantes A.M., Bloom E.L., Strong D.R., Riebe D., Marcus B.H., Desaulneirs J., Fokas K., Brown R.A. A preliminary randomized controlled trial of a behavioral exercise intervention for smoking cessation. Nicotine Tob. Res. 2014, 16:1094-1103.
2. Ainslie P.N., Reilly T., Maclaren D.P., Campbell I.T. Changes in plasma lipids and lipoproteins following 10-days of prolonged walking: influence of age and relationship to physical activity level. Ergonomics 2005, 48:1352-1364.
3. Azrin N.H., Ehle C.T., Beaumont A.L. Physical exercise as a reinforcer to promote calmness of an ADHD child. Behav. Mod. 2006, 30:564-570.
4. Bardo M.T., Hammer R.P. Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: resistance to differential rearing conditions. Neuroscience 1991, 45:281-290.
5. Bensimhon D.R., Kraus W.E., Donahue M.P. Obesity and physical activity: a review. Am. Heart J. 2006, 151:598-603.
6. Bock B.C., Marcus B.H., King T.K., Borrelli B., Roberts M.R. Exercise effects on withdrawal and mood among women attempting smoking cessation. Addict. Behav. 1999, 24:399-410.
7. Boecker H., Henriksen G., Sprenger T., Miederer I., Willoch F., Valet M., Berthele A., Tolle T.R. Positron emission tomography ligand activation studies in the sports sciences: measuring neurochemistry in vivo. Methods (San Diego, Calif) 2008, 45:307-318.
8. Boecker H., Sprenger T., Spilker M.E., Henriksen G., Koppenhoefer M., Wagner K.J., Valet M., Berthele A., Tolle T.R. The runner's high: opioidergic mechanisms in the human brain. Cereb. Cortex (New York, NY: 1991) 2008, 18:2523-2531.
9. Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., Rasbach K.A., Bostrom E.A., Choi J.H., Long J.Z., Kajimura S., Zingaretti M.C., Vind B.F., Tu H., Cinti S., Hojlund K., Gygi S.P., Spiegelman B.M. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
10. Brene S., Bjornebekk A., Aberg E., Mathe A.A., Olson L., Werme M. Running is rewarding and antidepressive. Physiol. Behav. 2007, 92:136-140.
11. Brown T., Summerbell C. Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: an update to the obesity guidance produced by the National Institute for Health and Clinical Excellence. Obes. Rev. 2009, 10:110-141.
12. Brown H.E., Pearson N., Braithwaite R.E., Brown W.J., Biddle S.J. Physical activity interventions and depression in children and adolescents: a systematic review and meta-analysis. Sports Med. 2013, 43:195-206.
13. Brown R.A., Abrantes A.M., Minami H., Read J.P., Marcus B.H., Jakicic J.M., Strong D.R., Dubreuil M.E., Gordon A.A., Ramsey S.E., Kahler C.W., Stuart G.L. A preliminary, randomized trial of aerobic exercise for alcohol dependence. J. Subst. Abuse Treat. 2014, 47:1-9.
14. Buchowski M.S., Meade N.N., Charboneau E., Park S., Dietrich M.S., Cowan R.L., Martin P.R. Aerobic exercise training reduces cannabis craving and use in non-treatment seeking cannabis-dependent adults. PLoS ONE 2011, 6:e17465.
15. Budde H., Windisch C., Kudielka B.M., Voelcker-Rehage C. Saliva cortisol in school children after acute physical exercise. Neurosci. Lett. 2010, 483:16-19.
16. Butts K.A., Weinberg J., Young A.H., Phillips A.G. Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:18459-18464.
17. Calipari E.S., Ferris M.J., Zimmer B.A., Roberts D.C., Jones S.R. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology 2013, 38:2385-2392.
18. Chaddock L., Erickson K.I., Prakash R.S., Kim J.S., Voss M.W., Vanpatter M., Pontifex M.B., Raine L.B., Konkel A., Hillman C.H., Cohen N.J., Kramer A.F. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 2010, 1358:172-183.
19. Chaddock-Heyman L., Erickson K.I., Voss M.W., Knecht A.M., Pontifex M.B., Castelli D.M., Hillman C.H., Kramer A.F. The effects of physical activity on functional MRI activation associated with cognitive control in children: a randomized controlled intervention. Front. Hum. Neurosci. 2013, 7:72.
20. Chen H.I., Kuo Y.M., Liao C.H., Jen C.J., Huang A.M., Cherng C.G., Su S.W., Yu L. Long-term compulsive exercise reduces the rewarding efficacy of 3,4-methylenedioxymethamphetamine. Behav. Brain Res. 2008, 187:185-189.
21. Colcombe S.J., Erickson K.I., Scalf P.E., Kim J.S., Prakash R., McAuley E., Elavsky S., Marquez D.X., Hu L., Kramer A.F. Aerobic exercise training increases brain volume in aging humans. J. Gerontol., A: Biol. Sci. Med. Sci. 2006, 61:1166-1170.
22. Collingwood T.R., Reynolds R., Kohl H.W., Smith W., Sloan S. Physical fitness effects on substance abuse risk factors and use patterns. J. Drug Educ. 1991, 21:73-84.
23. Comer S.D., Lac S.T., Wyvell C.L., Carroll M.E. Combined effects of buprenorphine and a nondrug alternative reinforcer on i.v. cocaine self-administration in rats maintained under FR schedules. Psychopharmacology 1996, 125:355-360.
24. Cosgrove K.P., Hunter R.G., Carroll M.E. Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences. Pharmacol. Biochem. Behav. 2002, 73:663-671.
25. Cotman C.W., Berchtold N.C. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement. 2007, 3:S30-S37.
26. Craig S.B., Bandini L.G., Lichtenstein A.H., Schaefer E.J., Dietz W.H. The impact of physical activity on lipids, lipoproteins, and blood pressure in preadolescent girls. Pediatrics 1996, 98:389-395.
27. Crews F.T., Nixon K., Wilkie M.E. Exercise reverses ethanol inhibition of neural stem cell proliferation. Alcohol (Fayetteville, NY) 2004, 33:63-71.
28. Cych P., Kosendiak A., Kalwa M., Kosendiak J. Physical activity versus alcohol consumption among teenagers in chosen middle schools from cities central and south-western Poland. Adv. Clin. Exp. Med. 2013, 22:273-281.
29. Czoty P.W., Martelle J.L., Nader M.A. Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology 2010, 209:375-382.
30. Daley A. Exercise and depression: a review of reviews. J. Clin. Psychol. Med. Settings 2008, 15:140-147.
31. Davis C.L., Tomporowski P.D., McDowell J.E., Austin B.P., Miller P.H., Yanasak N.E., Allison J.D., Naglieri J.A. Exercise improves executive function and achievement and alters brain activation in overweight children: a randomized, controlled trial. Health Psychol. 2011, 30:91-98.
32. Diamond A., Lee K. Interventions shown to aid executive function development in children 4 to 12 years old. Science 2011, 333:959-964.
33. Diamond M., Rosenzweig M.R., Krech D. Relationships between body weight and skull development in rats raised in enriched and impoverished conditions. J. Exp. Zool. 1965, 160:29-35.
34. Dolezal B.A., Chudzynski J., Storer T.W., Abrazado M., Penate J., Mooney L., Dickerson D., Rawson R.A., Cooper C.B. Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment. J. Addict. Med. 2013, 7:122-128.
35. Dolezal B.A., Chudzynski J., Dickerson D., Mooney L., Rawson R.A., Garfinkel A., Cooper C.B. Exercise training improves heart rate variability after methamphetamine dependency. Med. Sci. Sports Exerc. 2014, 46:1057-1066.
36. Eckert M.J., Abraham W.C. Effects of environmental enrichment exposure on synaptic transmission and plasticity in the hippocampus. Curr. Top. Behav. Neurosci. 2013, 15:165-187.
37. Engelmann A.J., Aparicio M.B., Kim A., Sobieraj J.C., Yuan C.J., Grant Y., Mandyam C.D. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase. Brain Struct. Funct. 2013, 219:657-672.
38. Ensari I., Greenlee T.A., Motl R.W., Petruzzello S.J. Meta-analysis of acute exercise effects on state anxiety: an update of randomized controlled trials over the past 25 years. Depress. Anxiety 2015, 1-11. 10.1002/da.22370.
39. Erickson K.I., Voss M.W., Prakash R.S., Basak C., Szabo A., Chaddock L., Kim J.S., Heo S., Alves H., White S.M., Wojcicki T.R., Mailey E., Vieira V.J., Martin S.A., Pence B.D., Woods J.A., McAuley E., Kramer A.F. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3017-3022.
40. Etnier J.L., Nowell P.M., Landers D.M., Sibley B.A. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res. Rev. 2006, 52:119-130.
41. Fontes-Ribeiro C.A., Marques E., Pereira F.C., Silva A.P., Macedo T.R. exercise prevent addiction?. Curr. Neuropharmacol. 2011, 9(May):45-48.
42. Gallego X., Cox R.J., Funk E., Foster R.A., Ehringer M.A. Voluntary exercise decreases ethanol preference and consumption in C57BL/6 adolescent mice: sex differences and hippocampal BDNF expression. Physiol. Behav. 2015, 138:28-36.
43. Gelfo F., De Bartolo P., Giovine A., Petrosini L., Leggio M.G. Layer and regional effects of environmental enrichment on the pyramidal neuron morphology of the rat. Neurobiol. Learn. Mem. 2009, 91:353-365.
44. Geuzaine A., Tirelli E. Wheel-running mitigates psychomotor sensitization initiation but not post-sensitization conditioned activity and conditioned place preference induced by cocaine in mice. Behav. Brain Res. 2014, 262:57-67.
45. Giesen E.S., Deimel H., Bloch W. Clinical exercise interventions in alcohol use disorders: a systematic review. J. Subst. Abuse Treat. 2015, 52:1-9.
46. Gilliam P.E., Spirduso W.W., Martin T.P., Walters T.J., Wilcox R.E., Farrar R.P. The effects of exercise training on [3H]-spiperone binding in rat striatum. Pharmacol. Biochem. Behav. 1984, 20:863-867.
47. Goeders N.E., Smith J.E. Cortical dopaminergic involvement in cocaine reinforcement. Science 1983, 221:773-775.
48. Gondoh Y., Sensui H., Kinomura S., Fukuda H., Fujimoto T., Masud M., Nagamatsu T., Tamaki H., Takekura H. Effects of aerobic exercise training on brain structure and psychological well-being in young adults. J. Sports Med. Phys. Fit. 2009, 49:129-135.
49. Goodwin H., Haycraft E., Meyer C. The relationship between compulsive exercise and emotion regulation in adolescents. Br. J. Health Psychol. 2012, 17:699-710.
50. Gould T.J. Addiction and cognition. Addict. Sci. Clin. Pract. 2010, 5:4-14.
51. Greenwood B.N., Foley T.E., Le T.V., Strong P.V., Loughridge A.B., Day H.E., Fleshner M. Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway. Behav. Brain Res. 2011, 217:354-362.
52. Griffin K.W., Botvin G.J. Evidence-based interventions for preventing substance use disorders in adolescents. Child Adolesc. Psychiatr. Clin. N. Am. 2010, 19:505-526.
53. Haasova M., Warren F.C., Ussher M., Janse Van Rensburg K., Faulkner G., Cropley M., Byron-Daniel J., Everson-Hock E.S., Oh H., Taylor A.H. The acute effects of physical activity on cigarette cravings: systematic review and meta-analysis with individual participant data. Addiction (Abingdon, England) 2013, 108:26-37.
54. Hansen W.B. Current and future directions in elementary school drug prevention. J. Drug Educ. 2010, 40:91-98.
55. Hattori S., Naoi M., Nishino H. Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running. Brain Res. Bull. 1994, 35:41-49.
56. Heishman S.J., Schuh K.J., Schuster C.R., Henningfield J.E., Goldberg S.R. Reinforcing and subjective effects of morphine in human opioid abusers: effect of dose and alternative reinforcer. Psychopharmacology 2000, 148:272-280.
57. Henchoz Y., Dupuis M., Deline S., Studer J., Baggio S., N'Goran A.A., Daeppen J.B., Gmel G. Associations of physical activity and sport and exercise with at-risk substance use in young men: a longitudinal study. Prev. Med. 2014, 64:27-31.
58. Hillman C.H., Pontifex M.B., Raine L.B., Castelli D.M., Hall E.E., Kramer A.F. The effect of acute treadmill walking on cognitive control and academic achievement in preadolescent children. Neuroscience 2009, 159:1044-1054.
59. Hillman C.H., Pontifex M.B., Castelli D.M., Khan N.A., Raine L.B., Scudder M.R., Drollette E.S., Moore R.D., Wu C.T., Kamijo K. Effects of the FITKids randomized controlled trial on executive control and brain function. Pediatrics 2014, 134:e1063-e1071.
60. Holley J., Crone D., Tyson P., Lovell G. The effects of physical activity on psychological well-being for those with schizophrenia: a systematic review. Br. J. Child Psychol. 2011, 50:84-105.
61. Horn K., Dino G., Branstetter S.A., Zhang J., Noerachmanto N., Jarrett T., Taylor M. Effects of physical activity on teen smoking cessation. Pediatrics 2011, 128:e801-e811.
62. Hosseini M., Alaei H.A., Naderi A., Sharifi M.R., Zahed R. Treadmill exercise reduces self-administration of morphine in male rats. Pathophysiology 2009, 16:3-7.
63. Huang C.J., Webb H.E., Zourdos M.C., Acevedo E.O. Cardiovascular reactivity, stress, and physical activity. Front. Physiol. 2013, 4:314.
64. Hudziak J.J., Albaugh M.D., Ducharme S., Karama S., Spottswood M., Crehan E., Evans A.C., Botteron K.N. Cortical thickness maturation and duration of music training: health-promoting activities shape brain development. J. Am. Acad. Child Adolesc. Psychiatry 2014, 53:1153-1161. (e1152).
65. Iannotti R.J., Kogan M.D., Janssen I., Boyce W.F. Patterns of adolescent physical activity, screen-based media use, and positive and negative health indicators in the U.S. and Canada. J. Adolesc. Health 2009, 44:493-499.
66. Irons J.G., Babson K.A., Bergeria C.L., Bonn-Miller M.O. Physical activity and cannabis cessation. Am. J. Addict. 2014, 23:485-492.
67. Janse Van Rensburg K., Taylor A., Hodgson T., Benattayallah A. Acute exercise modulates cigarette cravings and brain activation in response to smoking-related images: an fMRI study. Psychopharmacology 2009, 203:589-598.
68. Johnson M.W., Bickel W.K., Kirshenbaum A.P. Substitutes for tobacco smoking: a behavioral economic analysis of nicotine gum, denicotinized cigarettes, and nicotine-containing cigarettes. Drug Alcohol Depend. 2004, 74:253-264.
69. Kadota T., Kadota K. Neurotoxic morphological changes induced in the medial prefrontal cortex of rats behaviorally sensitized to methamphetamine. Arch. Histol. Cytol. 2004, 67:241-251.
70. Kamijo K., Pontifex M.B., O'Leary K.C., Scudder M.R., Wu C.T., Castelli D.M., Hillman C.H. The effects of an afterschool physical activity program on working memory in preadolescent children. Dev. Sci. 2011, 14:1046-1058.
71. Kanarek R.B., Marks-Kaufman R., D'Anci K.E., Przypek J. Exercise attenuates oral intake of amphetamine in rats. Pharmacol. Biochem. Behav. 1995, 51:725-729.
72. Karoly H.C., Stevens C.J., Thayer R.E., Magnan R.E., Bryan A.D., Hutchison K.E. Aerobic exercise moderates the effect of heavy alcohol consumption on white matter damage. Alcohol. Clin. Exp. Res. 2013, 37:1508-1515.
73. Kelly D.P. Medicine. Irisin, light my fire. Science 2012, 336:42-43.
74. Kendzor D.E., Dubbert P.M., Olivier J., Businelle M.S., Grothe K.B. The influence of physical activity on alcohol consumption among heavy drinkers participating in an alcohol treatment intervention. Addict. Behav. 2008, 33:1337-1343.
75. Kim A., Mandyam C.D. Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity. Pharmacol. Biochem. Behav. 2014, 126:90-96.
76. Kobilo T., Liu Q.R., Gandhi K., Mughal M., Shaham Y., van Praag H. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn. Mem. 2011, 18:605-609.
77. Koob G.F., Kenneth Lloyd G., Mason B.J. Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nat. Rev. Drug Discov. 2009, 8:500-515.
78. Koob G.F., Buck C.L., Cohen A., Edwards S., Park P.E., Schlosburg J.E., Schmeichel B., Vendruscolo L.F., Wade C.L., Whitfield T.W., George O. Addiction as a stress surfeit disorder. Neuropharmacology 2014, 76(Pt B):370-382.
79. Krafft C.E., Schwarz N.F., Chi L., Weinberger A.L., Schaeffer D.J., Pierce J.E., Rodrigue A.L., Yanasak N.E., Miller P.H., Tomporowski P.D., Davis C.L., McDowell J.E. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity 2014, 22:232-242.
80. Lacy R.T., Strickland J.C., Brophy M.K., Witte M.A., Smith M.A. Exercise decreases speedball self-administration. Life Sci. 2014, 114:86-92.
81. Lenoir M., Ahmed S.H. Supply of a nondrug substitute reduces escalated heroin consumption. Neuropsychopharmacology 2008, 33:2272-2282.
82. Lett B.T., Grant V.L., Koh M.T. Naloxone attenuates the conditioned place preference induced by wheel running in rats. Physiol. Behav. 2001, 72:355-358.
83. Lett B.T., Grant V.L., Koh M.T., Flynn G. Prior experience with wheel running produces cross-tolerance to the rewarding effect of morphine. Pharmacol. Biochem. Behav. 2002, 72:101-105.
84. Lett B.T. Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine. Psychopharmacology 1989, 98:357-362.
85. Linke S.E., Ussher M. Exercise-based treatments for substance use disorders: evidence, theory, and practicality. Am. J. Drug Alcohol Abuse 2015, 41:7-15.
86. Linke S.E., Ciccolo J.T., Ussher M., Marcus B.H. Exercise-based smoking cessation interventions among women. Women's Health (London, England) 2013, 9:69-84.
87. London E.D., Kohno M., Morales A.M., Ballard M.E. Chronic methamphetamine abuse and corticostriatal deficits revealed by neuroimaging. Brain Res. 2014, 104:734-741.
88. Lorrain D.S., Arnold G.M., Vezina P. Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule. Beahav. Brain Res. 2000, 107:9-19.
89. Lynch W.J., Carroll M.E. Regulation of drug intake. Exp. Clin. Psychopharmacol. 2001, 9:131-143.
90. Lynch W.J., Piehl K.B., Acosta G., Peterson A.B., Hemby S.E. Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex. Biol. Psychiatry 2010, 68:774-777.
91. Lynch W.J., Peterson A.B., Sanchez V., Abel J., Smith M.A. Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis. Neurosci. Biobehav. Rev. 2013, 37:1622-1644.
92. Mandyam C.D., Wee S., Eisch A.J., Richardson H.N., Koob G.F. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J. Neursci. 2007, 27:11442-11450.
93. Marcus B.H., Albrecht A.E., Niaura R.S., Taylor E.R., Simkin L.R., Feder S.I., Abrams D.B., Thompson P.D. Exercise enhances the maintenance of smoking cessation in women. Addict. Behav. 1995, 20:87-92.
94. Marcus B.H., Lewis B.A., Hogan J., King T.K., Albrecht A.E., Bock B., Parisi A.F., Niaura R., Abrams D.B. The efficacy of moderate-intensity exercise as an aid for smoking cessation in women: a randomized controlled trial. Nicotine Tob. Res. 2005, 7:871-880.
95. McClernon F.J., Hiott F.B., Huettel S.A., Rose J.E. Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues. Neuropsychopharmacology 2005, 30:1940-1947.
96. McGinty J.F., Whitfield T.W., Berglind W.J. Brain-derived neurotrophic factor and cocaine addiction. Brain Res. 2010, 1314:183-193.
97. Miller M.L., Vaillancourt B.D., Wright M.J., Aarde S.M., Vandewater S.A., Creehan K.M., Taffe M.A. Reciprocal inhibitory effects of intravenous d-methamphetamine self-administration and wheel activity in rats. Drug Alcohol Depend. 2012, 121:90-96.
98. Moffitt T.E., Arseneault L., Belsky D., Dickson N., Hancox R.J., Harrington H., Houts R., Poulton R., Roberts B.W., Ross S., Sears M.R., Thomson W.M., Caspi A. A gradient of childhood self-control predicts health, wealth, and public safety. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2693-2698.
99. Montoya I.D., Vocci F. Novel medications to treat addictive disorders. Curr. Psychiatry Rep. 2008, 10:392-398.
100. Moon H.S., Dincer F., Mantzoros C.S. Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines. Metabolism 2013, 62:1131-1136.
101. Morris M.J., Na E.S., Johnson A.K. Voluntary running-wheel exercise decreases the threshold for rewarding intracranial self-stimulation. Behav. Neursci. 2012, 126:582-587.
102. Mustroph M.L., Stobaugh D.J., Miller D.S., DeYoung E.K., Rhodes J.S. Wheel running can accelerate or delay extinction of conditioned place preference for cocaine in male C57BL/6J mice, depending on timing of wheel access. Eur. J. Neurosci. 2011, 34:1161-1169.
103. National Institutes of Health, NIH Common Fund launches physical activity research program, 2015a, http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-15-014.html.
104. National Institutes of Health, Adolescent brain cognitive development (ABCD)-Coordinating Center (U24), 2015b, http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-15-014.html.
105. Novelle M.G., Contreras C., Romero-Pico A., Lopez M., Dieguez C. Irisin, two years later. Int. J. Endocrinol. 2013, 2013:746281.
106. O'Dell S., Marshall J.J.F. Running wheel exercise before a binge regimen of methamphetamine does not protect against striatal dopaminergic damage. Synapse 2014, 68:419-425.
107. Ozburn A.R., Harris R.A., Blednov Y.A. Wheel running, voluntary ethanol consumption, and hedonic substitution. Alcohol 2008, 42:417-424.
108. Palmgreen P., Donohew L. Impact of SENTAR on prevention campaign policy and practice. Health Commun. 2010, 25:609-610.
109. Parcel G.S., Simons-Morton B., O'Hara N.M., Baranowski T., Wilson B. School promotion of healthful diet and physical activity: impact on learning outcomes and self-reported behavior. Health Educ. Q. 1989, 16:181-199.
110. Pentz M.A., Riggs N.R. Longitudinal relationships of executive cognitive function and parent influence to child substance use and physical activity. Prev. Sci. 2013, 14:229-237.
111. Perry J.L., Joseph J.E., Jiang Y., Zimmerman R.S., Kelly T.H., Darna M., Huettl P., Dwoskin L.P., Bardo M.T. Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. Brain Res. Rev. 2011, 65:124-149.
112. Peterson A.B., Abel J.M., Lynch W.J. Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats. Psychopharmacology 2014, 231:1305-1314.
113. Ploughman M. Exercise is brain food: the effects of physical activity on cognitive function. Dev. Neurorehabil. 2008, 11:236-240.
114. Prakash R.S., Voss M.W., Erickson K.I., Kramer A.F. Physical activity and cognitive vitality. Annu. Rev. Psychol. 2015, 66:769-797.
115. Prochaska J.J., Hall S.M., Humfleet G., Munoz R.F., Reus V., Gorecki J., Hu D. Physical activity as a strategy for maintaining tobacco abstinence: a randomized trial. Prev. Med. 2008, 47:215-220.
116. Prudencio C., Abrantes B., Lopes I., Tavares M.A. Structural and functional cellular alterations underlying the toxicity of methamphetamine in rat retina and prefrontal cortex. Ann. N.Y. Acad. Sci. 2002, 965:522-528.
117. Qin L., Knol M.J., Corpeleijn E., Stolk R.P. Does physical activity modify the risk of obesity for type 2 diabetes: a review of epidemiological data. Eur. J. Epidemiol. 2010, 25:5-12.
118. Rasmussen E.B., Hillman C. Naloxone and rimonabant reduce the reinforcing properties of exercise in rats. Exp. Clin. Psychopharmacol. 2011, 19:389-400.
119. Reynolds D., Nicolson R.I. Follow-up of an exercise-based treatment for children with reading difficulties. Dyslexia 2007, 13:78-96.
120. Rive M.M., van Rooijen G., Veltman D.J., Phillips M.L., Schene A.H., Ruhe H.G. Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies. Neurosci. Biobehav. Rev. 2013, 37:2529-2553.
121. Roberts V., Maddison R., Simpson C., Bullen C., Prapavessis H. The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect, and smoking behaviour: systematic review update and meta-analysis. Psychopharmacology 2012, 222:1-15.
122. Rozeske R.R., Greenwood B.N., Fleshner M., Watkins L.R., Maier S.F. Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference. Behav. Brain Res. 2011, 219:378-381.
123. Sanchez V., Moore C.F., Brunzell D.H., Lynch W.J. Effect of wheel-running during abstinence on subsequent nicotine-seeking in rats. Psychopharmacology 2013, 227:403-411.
124. Segat H.J., Kronbauer M., Roversi K., Schuster A.J., Vey L.T., Roversi K., Pase C.S., Antoniazzi C.T., Burger M.E. Exercise modifies amphetamine relapse: behavioral and oxidative markers in rats. Behav. Brain Res. 2014, 262:94-100.
125. Segovia G., del Arco A., Mora F. Environmental enrichment, prefrontal cortex, stress, and aging of the brain. J. Neural Transm. 2009, 116:1007-1016.
126. Shen X., Kosten T.R. Immunotherapy for drug abuse. CNS Neurol. Disord. Drug Targets 2011, 10:876-879.
127. Silva M.T., Heyman G.M. Chronic morphine consumption decreases wheel running and wheel running-reinforced behavior in rats. Pharmacol. Biochem. Behav. 2001, 69:51-57.
128. Sinyor D., Brown T., Rostant L., Seraganian P. The role of a physical fitness program in the treatment of alcoholism. J. Stud. Alcohol. 1982, 43:380-386.
129. Smith M.A., Lynch W.J. Exercise as a potential treatment for drug abuse: evidence from preclinical studies. Front. Psychiatry 2011, 2:82.
130. Smith M.A., Pitts E.G. Wheel running decreases the positive reinforcing effects of heroin. Pharmacol. Rep. 2012, 64:960-964.
131. Smith M.A., Witte M.A. The effects of exercise on cocaine self-administration, food-maintained responding, and locomotor activity in female rats: importance of the temporal relationship between physical activity and initial drug exposure. Exp. Clin. Psychopharmacol. 2012, 20:437-446.
132. Smith M.A., Gergans S.R., Iordanou J.C., Lyle M.A. Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine. Pharmacol. Rep. 2008, 60:561-565.
133. Smith M.A., Schmidt K.T., Iordanou J.C., Mustroph M.L. Aerobic exercise decreases the positive-reinforcing effects of cocaine. Drug Alcohol Depend. 2008, 98:129-135.
134. Smith M.A., Walker K.L., Cole K.T., Lang K.C. The effects of aerobic exercise on cocaine self-administration in male and female rats. Psychopharmacology 2011, 218:357-369.
135. Smith M.A., Pennock M.M., Walker K.L., Lang K.C. Access to a running wheel decreases cocaine-primed and cue-induced reinstatement in male and female rats. Drug Alcohol Depend. 2012, 121:54-61.
136. Sobieraj J.C., Kim A., Fannon M.J., Mandyam C.D. Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons. Brain Struct. Funct. 2014, (Epub ahead of print).
137. Stitzer M.L., McCaul M.E., Bigelow G.E., Liebson I.A. Oral methadone self-administration: effects of dose and alternative reinforcers. Clin. Pharmacol. Ther. 1983, 34:29-35.
138. Strohle A. Physical activity, exercise, depression and anxiety disorders. J. Neural Transm. 2009, 116:777-784.
139. Tashiro M., Itoh M., Fujimoto T., Masud M.M., Watanuki S., Yanai K. Application of positron emission tomography to neuroimaging in sports sciences. Methods 2008, 45:300-306.
140. Terry-McElrath Y.M., O'Malley P.M., Johnston L.D. Exercise and substance use among American youth, 1991-2009. Am. J. Prev. Med. 2011, 40:530-540.
141. Thanos P.K., Tucci A., Stamos J., Robison L., Wang G.J., Anderson B.J., Volkow N.D. Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats. Behav. Brain Res. 2010, 215:77-82.
142. Thanos P.K., Stamos J., Robison L.S., Heyman G., Tucci A., Wang G.J., Robinson J.K., Anderson B.J., Volkow N.D. Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement. Behav. Brain Res. 2013, 239:8-14.
143. Toborek M., Seelbach M.J., Rashid C.S., Andras I.E., Chen L., Park M., Esser K.A. Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood-brain barrier. Mol. Neurodegener. 2013, 8:22.
144. Trost A., Hauber W. Dopamine D1/D2 receptors do not mediate the expression of conditioned place preference induced by the aftereffect of wheel running. BMC Neurosci. 2014, 15:124.
145. Tsibulsky V.L., Norman A.B. Satiety threshold: a quantitative model of maintained cocaine self-administration. Brain Res. 1999, 839:85-93.
146. Ussher M., Cropley M., Playle S., Mohidin R., West R. Effect of isometric exercise and body scanning on cigarette cravings and withdrawal symptoms. Addiction (Abingdon, England) 2009, 104:1251-1257.
147. Ussher M.H., Taylor A., Faulkner G. Exercise interventions for smoking cessation. Cochrane Database Syst. Rev. 2012, (1). CD002295. 10.1002/14651858.CD002295.pub4.
148. Ussher M.H., Taylor A.H., Faulkner G.E. Exercise interventions for smoking cessation. Cochrane Database Syst. Rev. 2014, (8). CD002295. 10.1002/14651858.CD002295.pub5.
149. Van den Oever M.C., Spijker S., Smit A.B., De Vries T.J. Prefrontal cortex plasticity mechanisms in drug seeking and relapse. Neurosci. Biobehav. Rev. 2010, 35:276-284.
150. van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 1999, 2:266-270.
151. Van Rensburg K.J., Taylor A., Hodgson T. The effects of acute exercise on attentional bias towards smoking-related stimuli during temporary abstinence from smoking. Addiction (Abingdon, England) 2009, 104:1910-1917.
152. Vargas-Perez H., Sellings L.H., Paredes R.G., Prado-Alcala R.A., Diaz J.L. Reinforcement of wheel running in BALB/c mice: role of motor activity and endogenous opioids. J. Mot. Behav. 2008, 40:587-593.
153. Viola G.G., Rodrigues L., Americo J.C., Hansel G., Vargas R.S., Biasibetti R., Swarowsky A., Goncalves C.A., Xavier L.L., Achaval M., Souza D.O., Amaral O.B. Morphological changes in hippocampal astrocytes induced by environmental enrichment in mice. Brain Res. 2009, 1274:47-54.
154. Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Telang F. Addiction: beyond dopamine reward circuitry. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:15037-15042.
155. Voss M.W., Nagamatsu L.S., Liu-Ambrose T., Kramer A.F. Exercise, brain, and cognition across the life span. J. Appl. Physiol. 2011, 111:1505-1513.
156. Walker R., Morris D.W., Greer T.L., Trivedi M.H. Research staff training in a multisite randomized clinical trial: methods and recommendations from the stimulant reduction intervention using dosed exercise (STRIDE) trial. Addict. Res. Theory 2014, 22:407-415.
157. Wang G.J., Volkow N.D., Fowler J.S., Franceschi D., Logan J., Pappas N.R., Wong C.T., Netusil N. PET studies of the effects of aerobic exercise on human striatal dopamine release. J. Nucl. Med. 2000, 41:1352-1356.
158. Weinstock J., Barry D., Petry N.M. Exercise-related activities are associated with positive outcome in contingency management treatment for substance use disorders. Addict. Behav. 2008, 33:1072-1075.
159. Weinstock J., Capizzi J., Weber S.M., Pescatello L.S., Petry N.M. Exercise as an intervention for sedentary hazardous drinking college students: a pilot study. Ment. Health Phys. Act. 2014, 7:55-62.
160. Weiss L., Gass J., Egan J.E., Ompad D.C., Trezza C., Vlahov D. Understanding prolonged cessation from heroin use: findings from a community-based sample. J. Psychoactive Drugs 2014, 46:123-132.
161. Werme M., Thoren P., Olson L., Brene S. Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen. Eur. J. Neurosci. 2000, 12:2967-2974.
162. Werme M., Lindholm S., Thoren P., Franck J., Brene S. Running increases ethanol preference. Behav. Brain Res. 2002, 133:301-308.
163. Werme M., Messer C., Olson L., Gilden L., Thoren P., Nestler E.J., Brene S. Delta FosB regulates wheel running. J. Neurosci. 2002, 22:8133-8138.
164. Williams D.M., Whiteley J.A., Dunsiger S., Jennings E.G., Albrecht A.E., Ussher M.H., Ciccolo J.T., Parisi A.F., Marcus B.H. Moderate intensity exercise as an adjunct to standard smoking cessation treatment for women: a pilot study. Psychol. Addict. Behav. 2010, 24:349-354.
165. Wilson D.B., Smith B.N., Speizer I.S., Bean M.K., Mitchell K.S., Uguy L.S., Fries E.A. Differences in food intake and exercise by smoking status in adolescents. Prev. Med. 2005, 40:872-879.
166. Yanagisawa H., Dan I., Tsuzuki D., Kato M., Okamoto M., Kyutoku Y., Soya H. Acute moderate exercise elicits increased dorsolateral prefrontal activation and improves cognitive performance with Stroop test. NeuroImage 2010, 50:1702-1710.
167. Zernig G., Ahmed S.H., Cardinal R.N., Morgan D., Acquas E., Foltin R.W., Vezina P., Negus S.S., Crespo J.A., Stockl P., Grubinger P., Madlung E., Haring C., Kurz M., Saria A. Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests. Pharmacology 2007, 80:65-119.
168. Zlebnik N.E., Anker J.J., Gliddon L.A., Carroll M.E. Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats. Psychopharmacology 2010, 209:113-125.
169. Zlebnik N.E., Anker J.J., Carroll M.E. Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats. Psychopharmacology 2012, 224:387-400.
170. Zschucke E., Heinz A., Strohle A. Exercise and physical activity in the therapy of substance use disorders. Sci. World J. 2012, 2012:901741.