Systematic evaluation of Drosophila CRISPR tools reveals safe and robust alternatives to autonomous gene drives in basic research

G3: Genes, Genomes, Genetics

Volumn 5, Issue 7, 2015, Pages 1493-1502

  Port, Fillip ^a   Muschalik, Nadine ^a   Bullock, Simon L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Crispr; Drosophila; Gene drive; Homology directed repair; Mutagenesis

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CRISPR ASSOCIATED PROTEIN; GRNA; REAGENT; RNA; UNCLASSIFIED DRUG; GUIDE RNA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASIC RESEARCH; BINDING SITE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DROSOPHILA; EMBRYO; FEMALE; GENE TARGETING; GENE TECHNOLOGY; GENETIC ENGINEERING; GENOTYPE; INSECT GENOME; MALE; NONHUMAN; RNA EDITING; SEQUENCE ANALYSIS; TRANSGENE; TRANSGENICS; ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENETICS; GERM CELL; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTAGENESIS; NONMAMMALIAN EMBRYO; TRANSGENIC ANIMAL;

DROSOPHILA MELANOGASTER;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DROSOPHILA; EMBRYO, NONMAMMALIAN; GENE KNOCK-IN TECHNIQUES; GERM CELLS; MUTAGENESIS; RNA, GUIDE;

EID: 84937605773     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.115.019083     Document Type: Article

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