Chemoreceptor responsiveness at sea level does not predict the pulmonary pressure response to high altitude

Chest

Volumn 148, Issue 1, 2015, Pages 219-225

  Hoiland, Ryan L ^a   Foster, Glen E ^a   Donnelly, Joseph ^b,c   Stembridge, Mike ^d   Willie, Chris K ⁱ   Smith, Kurt J ^a   Lewis, Nia C ⁱ   Lucas, Samuel J E ^c,e   Cotter, Jim D ^c   Yeoman, David J ^f   Thomas, Kate N ^c   Day, Trevor A ^g   Tymko, Mike M ^a   Burgess, Keith R ^h   Ainslie, Philip N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f UNIVERSITY OF OTAGO   (New Zealand)

^g MOUNT ROYAL UNIVERSITY   (Canada)

^h UNIVERSITY OF SYDNEY   (Australia)

ⁱ NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALTITUDE; ARTICLE; BREATHING; CHEMORECEPTOR; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; FEMALE; HEMATOCRIT; HUMAN; HYPOXIC VENTILATORY RESPONSE; LUNG PRESSURE; MALE; NORMAL HUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; PULMONARY ARTERY SYSTOLIC PRESSURE; PULSE OXIMETRY; SEA LEVEL; ACCLIMATIZATION; ANOXIA; ARTERIAL PRESSURE; BLOOD; CHEMORECEPTOR CELL; HYPERCAPNIA; OXIMETRY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR REFLEX; PULMONARY ARTERY; VASCULAR RESISTANCE; YOUNG ADULT;

OXYGEN;

ACCLIMATIZATION; ADULT; ALTITUDE; ANOXIA; ARTERIAL PRESSURE; BAROREFLEX; CHEMORECEPTOR CELLS; FEMALE; HUMANS; HYPERCAPNIA; MALE; OXIMETRY; OXYGEN; PULMONARY ARTERY; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 84937566605     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.14-1992     Document Type: Article

References (50)

1. Hirshman CA, McCullough RE, Weil JV. Normal values for hypoxic and hypercapnic ventilatory drives in man. J Appl Physiol. 1975;38(6):1095-1098.
2. Motley HL, Cournand A, Werko L, Himmelstein A, Dresdale D. The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol. 1947;150(2):315-320.
3. Maggiorini M, Mélot C, Pierre S, et al. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation. 2001;103(16):2078-2083.
4. Maggiorini M, Brunner-La Rocca HP, Peth S, et al. Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial. Ann Intern Med. 2006;145(7):497-506.
5. Swenson ER, Maggiorini M, Mongovin S, et al. Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor. JAMA. 2002;287(17):2228-2235.
6. Grünig E, Mereles D, Hildebrandt W, et al. Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J Am Coll Cardiol. 2000;35(4):980-987.
7. Kawashima A, Kubo K, Kobayashi T, Sekiguchi M. Hemodynamic responses to acute hypoxia, hypobaria, and exercise in subjects susceptible to high-altitude pulmonary edema. J Appl Physiol (1985). 1989;67(5):1982-1989.
8. Hultgren HN, Grover RF, Hartley LH. Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation. 1971;44(5):759-770.
9. Bärtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of highaltitude pulmonary edema by nifedipine. N Engl J Med. 1991;325(18):1284-1289.
10. Levitzky MG. Chemoreceptor stimulation and hypoxic pulmonary vasoconstriction in conscious dogs. Respir Physiol. 1979;37(2):151-160.
11. Levitzky MG, Newell JC, Krasney JA, Dutton RE. Chemoreceptor influence on pulmonary blood flow during unilateral hypoxia in dogs. Respir Physiol. 1977;31(3):345-356.
12. Daly ID, Daly MD. The effects of stimulation of the carotid sinus baroreceptors on the pulmonary vascular bed in the dog. J Physiol. 1959;148:220-226.
13. Fitzgerald RS, Dehghani GA, Sham JS, Shirahata M, Mitzner WA. Peripheral chemoreceptor modulation of the pulmonary vasculature in the cat. J Appl Physiol (1985). 1992;73(1):20-29.
14. Albert TJ, Swenson ER. Peripheral chemoreceptor responsiveness and hypoxic pulmonary vasoconstriction in humans. High Alt Med Biol. 2014;15(1):15-20.
15. Ainslie PN, Lucas SJ, Burgess KR. Breathing and sleep at high altitude. Respir Physiol Neurobiol. 2013;188(3):233-256.
16. White DP, Gleeson K, Pickett CK, Rannels AM, Cymerman A, Weil JV. Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep. J Appl Physiol (1985). 1987;63(1):401-412.
17. Sato M, Severinghaus JW, Powell FL, Xu FD, Spellman MJ Jr. Augmented hypoxic ventilatory response in men at altitude. J Appl Physiol (1985). 1992;73(1):101-107.
18. Dwinell MR, Powell FL. Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. J Appl Physiol (1985). 1999;87(2):817-823.
19. Barnard P, Andronikou S, Pokorski M, Smatresk N, Mokashi A, Lahiri S. Timedependent effect of hypoxia on carotid body chemosensory function. J Appl Physiol (1985). 1987;63(2):685-691.
20. Gallman EA, Millhorn DE. Two long-lasting central respiratory responses following acute hypoxia in glomectomized cats. J Physiol. 1988;395:333-347.
21. Swenson ER. Hypoxic pulmonary vasoconstriction. High Alt Med Biol. 2013;14(2):101-110.
22. Basnyat B, Gertsch JH, Holck PS, et al. Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trial. High Alt Med Biol. 2006;7(1):17-27.
23. Ritschel WA, Paulos C, Arancibia A, Agrawal MA, Wetzelsberger KM, Lücker PW. Pharmacokinetics of acetazolamide in healthy volunteers after short- and long-term exposure to high altitude. J Clin Pharmacol. 1998;38(6):533-539.
24. Richalet J-P, Rivera M, Bouchet P, et al. Acetazolamide: a treatment for chronic mountain sickness. Am J Respir Crit Care Med. 2005;172(11):1427-1433.
25. Ke T, Wang J, Swenson ER, et al. Effect of acetazolamide and gingko biloba on the human pulmonary vascular response to an acute altitude ascent. High Alt Med Biol. 2013;14(2):162-167.
26. Donnelly J, Cowan DC, Yeoman DJ, et al. Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respir Physiol Neurobiol. 2011;177(3):213-217.
27. Lucas SJE, Burgess KR, Thomas KN, et al. Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol. 2011;589(pt 3):741-753.
28. Stembridge M, Ainslie PN, Hughes MG, et al. Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs short-term lowlander adaptation. J Appl Physiol (1985). 2014;117(3):334-343.
29. Foster GE, Ainslie PN, Stembridge M, et al. Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas. J Physiol. 2014;592(pt 6):1397-1409.
30. Ainslie PN. On the nature of research at high altitude: packing it all in! Exp Physiol. 2014;99(5):741-742.
31. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685-713.
32. Querido JS, Ainslie PN, Foster GE, et al. Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide. J Appl Physiol (1985). 2013;114(9):1183-1190.
33. Naeije R, Vanderpool R. Pulmonary hypertension and chronic mountain sickness. High Alt Med Biol. 2013;14(2):117-125.
34. Muza SR, Rock PB, Fulco CS, et al. Women at altitude: ventilatory acclimatization at 4,300 m. J Appl Physiol (1985). 2001;91(4):1791-1799.
35. Bhaumik G, Sharma RP, Dass D, et al. Hypoxic ventilatory response changes of men and women 6 to 7 days after climbing from 2100 m to 4350 m altitude and after descent. High Alt Med Biol. 2003;4(3):341-348.
36. Nielsen AM, Bisgard GE, Vidruk EH. Carotid chemoreceptor activity during acute and sustained hypoxia in goats. J Appl Physiol (1985). 1988;65(4):1796-1802.
37. Vizek M, Pickett CK, Weil JV. Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia. J Appl Physiol (1985). 1987;63(6):2403-2410.
38. Dwinell MR, Huey KA, Powell FL. Chronic hypoxia induces changes in the central nervous system processing of arterial chemoreceptor input. Adv Exp Med Biol. 2000;475:477-484.
39. Agostoni P, Swenson ER, Bussotti M, et al HIGHCARE Investigators. Highaltitude exposure of three weeks duration increases lung diffusing capacity in humans. J Appl Physiol (1985). 2011;110(6):1564-1571.
40. Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills WJ Jr. Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol (1985). 1988;64(3):1268-1272.
41. Hohenhaus E, Paul A, McCullough RE, Kücherer H, Bärtsch P. Ventilatory and pulmonary vascular response to hypoxia and susceptibility to high altitude pulmonary oedema. Eur Respir J. 1995;8(11):1825-1833.
42. Moore LG, Harrison GL, McCullough RE, et al. Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness. J Appl Physiol (1985). 1986;60(4):1407-1412.
43. Milledge JS, Beeley JM, Broome J, Luff N, Pelling M, Smith D. Acute mountain sickness susceptibility, fitness and hypoxic ventilatory response. Eur Respir J. 1991;4(8):1000-1003.
44. Canepa A, Chavez R, Hurtado A, Rotta A, Velasquez T. Pulmonary circulation at sea level and at high altitudes. J Appl Physiol. 1956;9(3):328-336.
45. Euler U, Liljestrand G. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand. 1946; 12(4):301-320.
46. Kronenberg RS, Safar P, Leej, et al. Pulmonary artery pressure and alveolar gas exchange in man during acclimatization to 12,470 ft. J Clin Invest. 1971;50(4):827-837.
47. Penaloza D, Arias-Stella J. The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness. Circulation. 2007;115(9):1132-1146.
48. Faoro V, Huez S, Vanderpool R, et al. Pulmonary circulation and gas exchange at exercise in Sherpas at high altitude. J Appl Physiol (1985). 2014;116(7):919-926.
49. Welsh DJ, Peacock AJ. Cellular responses to hypoxia in the pulmonary circulation. High Alt Med Biol. 2013;14(2):111-116.
50. Beall CM, Laskowski D, Strohl KP, et al. Pulmonary nitric oxide in mountain dwellers. Nature. 2001;414(6862):411-412.