Effect of acetazolamide and gingko biloba on the human pulmonary vascular response to an acute altitude ascent

High Altitude Medicine and Biology

Volumn 14, Issue 2, 2013, Pages 162-167

  Ke, Tao ^a   Wang, Jiye ^a   Swenson, Erik R ^b   Zhang, Xiangnan ^a   Hu, Yunlong ^a   Chen, Yaoming ^a   Liu, Mingchao ^a   Zhang, Wenbin ^a   Zhao, Feng ^c   Shen, Xuefeng ^a   Yang, Qun ^a   Chen, Jingyuan ^a   Luo, Wenjing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acetazolamide; Acute mountain sickness; Gingko Biloba; Pulmonary artery systolic pressure; Randomized controlled trial

Indexed keywords

ACETAZOLAMIDE; GINKGO BILOBA EXTRACT; PLACEBO;

ADOLESCENT; ADULT; ALTITUDE; ALTITUDE DISEASE; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEART RATE; HUMAN; LUNG ARTERY PRESSURE; MALE; MEAN ARTERIAL PRESSURE; PARESTHESIA; PEAK EXPIRATORY FLOW; POLYURIA; PRIORITY JOURNAL; PULMONARY ARTERY SYSTOLIC PRESSURE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME;

ACETAZOLAMIDE; ACUTE DISEASE; ADOLESCENT; ALTITUDE SICKNESS; ANTIHYPERTENSIVE AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUGS, CHINESE HERBAL; GINKGO BILOBA; HUMANS; HYPERTENSION, PULMONARY; LINEAR MODELS; MALE; PHYTOTHERAPY; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84879677510     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2012.1099     Document Type: Article

References (32)

1. Allemann Y, Sartori C, Lepori M, Pierre S, Mélot C, Naeije R, Scherrer U, Maggiorini M. (2000). Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude. Am J Physiol Heart Circ Physiol 279:H2013-2016
2. Balanos GM, Talbot NP, Dorrington KL, Robbins PA. (2003). Human pulmonary vascular response to 4 h of hypercapnia and hypocapnia measured using Doppler echocardiography. J Appl Physiol 94:1543-1551 (Pubitemid 36348834)
3. Bärtsch P, Mairbäurl H, Maggiorini M, Swenson ER. (2005). Physiological aspects of high-Altitude pulmonary edema. J Appl Physiol 98:1101-1110 (Pubitemid 40283696)
4. Basnyat B, Gertsch JH, Holck PS, Johnson EW, Luks AM, Donham BP, Fleischman RJ, Gowder DW, Hawksworth JS, Jensen T, Kleiman RJ, Loveridge AH, Lundeen EB, Newman SL, Noboa JA, Miegs DP, O'Beirne KA, Philpot KB, Schultz MN, Valente MC, Wiebers MR, Swenson ER. (2006). Acetazolamide 125mg BD is not significantly different from 375mg BD in the prevention of acute mountain sickness: The prophylactic acetazolamide dosage comparison for efficacy (PACE) trial. High Alt Med Biol 7:17-27
5. Basnyat B, Gertsch JH, Johnson EW, Castro-Marin F, Inoue Y, Yeh C. (2003). Efficacy of low-Dose acetazolamide (125mg BID) for the prophylaxis of acute mountain sickness: A prospective, double-blind, randomized, placebo-controlled trial. High Alt Med Biol 4:45-52 (Pubitemid 36511798)
6. Basnyat B, Hargrove J, Holck PS, Srivastav S, Alekh K, Ghimire LV, Pandey K, Griffiths A, Shankar R, Kaul K, Paudyal A, Stasiuk D, Basnyat R, Davis C, Southard A, Robinson C, Shandley T, Johnson DW, Zafren K, Williams S, Weiss EA, Farrar JJ, and Swenson ER. (2008). Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans. High Alt Med Biol 9:209-216
7. Basnyat B, Murdoch DR. (2003). High-Altitude illness. Lancet 361:1967-1974 (Pubitemid 36694589)
8. Berg JT. (2004). Ginkgo biloba extract prevents high altitude pulmonary edema in rats. High Alt Med Biol 5:429-434 (Pubitemid 40309551)
9. Berg JT, Ramanathan S, Swenson ER. (2004). Inhibitors of hypoxic pulmonary vasoconstriction prevent high-Altitude pulmonary edema in rats. Wilderness Environ Med 15:32-37 (Pubitemid 38326087)
10. Deem S, Hedges RG, Kerr ME, Swenson ER. (2000). Acetazolamide reduces hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs. Respir Physiol 123:109-119
11. Emery CJ, Sloan PJ, Mohammed FH, Barer GR. (1977). The action of hypercapnia during hypoxia on pulmonary vessels. Bull Eur Physiopathol Respir 13:763-776 (Pubitemid 8212551)
12. Faoro V, Huez S, Giltaire S, Pavelescu A, Van Osta A, Moraine JJ, Guenard H, Martinot JB, and Naeije R. (2007). Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes. J Appl Physiol 103:1161-1165 (Pubitemid 47605949)
13. Grünig E, Mereles D, Hildebrandt W, Swenson ER, Kübler W, Kuecherer H, Bärtsch P. (2000). Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J Am Coll Cardiol 35:980-987 (Pubitemid 30189932)
14. Hohne C, Krebs MO, Seiferheld M, Boemke W, Kaczmarczyk G, Swenson ER. (2004). Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs. J Appl Physiol 97:515-521 (Pubitemid 38963118)
15. Hohne C, Pickerodt PA, Francis RC, Boemke W, Swenson ER. (2007). Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol 292:L178-184 (Pubitemid 46103442)
16. Hopkins SR, Garg J, Bolar DS, Balouch J, Levin DL. (2005). Pulmonary blood flow heterogeneity during hypoxia and high-Altitude pulmonary edema. Am J Respir Crit Care Med 171:83-87 (Pubitemid 40051700)
17. Kawashima A, Kubo K, Matsuzawa Y, Kobayashi T, Sekiguchi M. (1992). Hypoxia-induced ANP secretion in subjects susceptible to high-Altitude pulmonary edema. Respir Physiol 89:309-317
18. Maggiorini M. (2006). High altitude-induced pulmonary oedema. Cardiovasc Res 72:41-50 (Pubitemid 44310641)
19. Maggiorini M, Brunner-La Rocca HP, Peth S, Fischler M, Böhm T, Bernheim A, Kiencke S, Bloch KE, Dehnert C, Naeije R, Lehmann T, Bärtsch P, Mairbäurl H. (2006). Both tadalafil and dexamethasone may reduce the incidence of high-Altitude pulmonary edema: A randomized trial. Ann Intern Med 145:497-506 (Pubitemid 46780953)
20. Maggiorini M, Mélot C, Pierre S, Pfeiffer F, Greve I, Sartori C, Lepori M, Hauser M, Scherrer U, and Naeije R. (2001). Highaltitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 103:2078-2083 (Pubitemid 32373011)
21. Moviat M, Pickkers P, Van der Voort PH, and Van der Hoeven J.G. 2006). Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients. Crit Care 10:R14
22. Peacock AJ, Challenor V, and Sutherland G. (1990). Estimation of pulmonary artery pressure by Doppler echocardiography in normal subjects made hypoxic. Respir Med 84:335-337 (Pubitemid 20271054)
23. Ren DC, Du GH, and Zhang JT. (2002). Protective effect of ginkgo iloba extract on endothelial cell against damage induced by oxidative stress. J Cardiovasc Pharmacol 40:809-814 (Pubitemid 35365078)
24. Richalet JP, Gratadour P, Robach P, Pham I, Déchaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, and Cornolo J. (2005). Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 171:275-281
25. Richalet JP, Rivera M, Bouchet P, Chirinos E, Onnen I, Petitjean O, Bienvenu A, Lasne F, Moutereau S, and León-Velarde F.(2005). Acetazolamide: A treatment for chronic mountain sickness. Am J Respir Crit Care Med 172:1427-1433 (Pubitemid 43069816)
26. Roach RC BP, Hackett PH, and Oelz O. (1993). The Lake Louise Acute Mountain Sickness Scoring System Hypoxia and Molecular Medicine: Proceedings of the 8th International Hypoxia Symposium, Lake Louise, Alberta, Canada. Sutton JR Coates G, and Houston CS (eds). Burlington, Vt: Queen City Printers
27. Shimoda LA, Luke T, Sylvester JT, Shih HW, Jain A, Swenson ER. (2007). Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am JPhysiol Lung Cell Mol Physiol 292:L1002-1012 (Pubitemid 46608247)
28. Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbäurl H, and Bärtsch P. (2002). Pathogenesis of highaltitude pulmonary edema: Inflammation is not an etiologic factor. JAMA 287:2228-2235 (Pubitemid 34441939)
29. Teppema LJ, Balanos GM, Steinback CD, Brown AD, Foster GE, Duff HJ, Leigh R, and Poulin MJ. (2007). Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia. Am J Respir Crit Care Med 175:277-281 (Pubitemid 46203132)
30. Tissot Van Patot MC, Leadbetter G 3rd, Keyes LE, Maakestad KM, Olson S, and Hackett PH. (2008). Prophylactic low-Dose acetazolamide reduces the incidence and severity of acute mountain sickness. High Alt Med Biol 9:289-293
31. Wu YZ, Li SQ, Zu XG, Du J, Wang FF. (2008). Ginkgo biloba extract improves coronary artery circulation in patients with coronary artery disease: Contribution of plasma nitric oxide and endothelin-1. Phytother Res 22:734-739 (Pubitemid 351955569)
32. Yock PG, Popp RL. (1984). Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 70:657-662 (Pubitemid 14020664) University (PCSIRT, IRT1112)