Pulmonary hypertension and chronic mountain sickness

High Altitude Medicine and Biology

Volumn 14, Issue 2, 2013, Pages 117-125

  Naeije, Robert ^a   Vanderpool, Rebecca ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Andean populations; Blood viscosity; Chronic mountain sickness; Himalayan populations; Pulmonary hypertension

Indexed keywords

ACETAZOLAMIDE; ENDOTHELIN RECEPTOR ANTAGONIST; HEMOGLOBIN; METHYLXANTHINE; PHOSPHODIESTERASE V INHIBITOR; PROSTACYCLIN;

AEROBIC EXERCISE; AIRWAY REMODELING; ALTITUDE DISEASE; ARTICLE; BLOOD VESSEL REACTIVITY; EXERCISE; HEART LEFT ATRIUM PRESSURE; HEART OUTPUT; HEART RIGHT VENTRICLE FAILURE; HEMATOCRIT; HEMODILUTION; HUMAN; HYPERCAPNIA; HYPERVOLEMIA; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG COMPLIANCE; LUNG DIFFUSION CAPACITY; LUNG GAS EXCHANGE; LUNG VASCULAR RESISTANCE; MATHEMATICAL MODEL; NONHUMAN; OXYGEN SATURATION; POLYCYTHEMIA; PRESSOR RESPONSE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEA LEVEL; VISCOSITY; WORKLOAD;

ALTITUDE SICKNESS; ANIMALS; BLOOD VISCOSITY; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; EXERCISE TOLERANCE; HUMANS; HYPERTENSION, PULMONARY; POLYCYTHEMIA; SOUTH AMERICA; SYNDROME; TIBET; VASOCONSTRICTION; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84879669631     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2012.1124     Document Type: Article

References (67)

1. Anand IS, Malhotra R, Chandershekhar Y, et al. (1990). Adult subacute mountain sickness: A syndrome of congestive heart failure in man at very high altitude. Lancet 335:561-565 (Pubitemid 20089240)
2. Argiento P, Vanderpool RR, Mule M, et al. (2012). Exercise stress echocardiography of the pulmonary circulation: Limits of normal and sex differences. Chest 142:1158-1165
3. Arias-Stella J, and Saldana M. (1963). The terminal portion of the pulmonary arterial tree in people native to high altitude. Circulation 28:915-925
4. Beall CM. (2000). Tibetan and Andean patterns of adaptation to high altitude hypoxia. Hum Biol 72:201-228 (Pubitemid 30132306)
5. Banchero N, Sime F, Penaloza D, Cruz J, Gamboa R, Marticorena E. (1966). Pulmonary pressure, cardiac output, and arterial oxygen saturation during exercise at high altitude and at sea level. Circulation 33:249-262
6. Bartsch P, Mairbäurl H, Maggiorini M, Swenson ER. (2005). Physiological aspects of high-Altitude pulmonary edema. J Appl Physiol 98:1101-1110 (Pubitemid 40283696)
7. Bossone E, D'Andrea A, D'Alto M, et al. (2013). Echocardiography in pulmonary arterial hypertension: From diagnosis to prognosis. J Am Soc Echocardiogr 26:1-14
8. Brutsaert TD. (2008). Do high-Altitude natives have an enhanced exercise performance at high altitude? Appl Physiol Nutr Metab 33:582-592
9. Champion HC, Michelakis ED, and Hassoun PM. (2009). Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: State of the art and clinical and research implications. Circulation 120:992-1007
10. Deem E, Hedges RG, Kerr ME, Swenson ER. (2000). Acetazolamide reduces hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs. Respir Physiol 123:109-119
11. Faoro V, Huez S, Giltaire S, et al. (2007). Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes. J Appl Physiol 103:1161-1165 (Pubitemid 47605949)
12. Galiè N, Hoeper MM, Humbert M, et al. (2009). Task Force for Diagnosis and Treatment of Pulmonary Hypertension of European Society of Cardiology (ESC); European Respiratory Society (ERS); International Society of Heart and Lung Transplantation (ISHLT), Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 34:1219-1263
13. Groepenhoff H, Overbeek MJ, Mulé M, et al. (2012). Exercise pathophysiology in patients with chronic mountain sickness. Chest 142:877-884
14. Grover RF, Wagner WW, McMurtry IF, Reeves JT. (1983). Pulmonary Circulation Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda MD: Am Physiol Soc sect 2, vol III, part 1, Chap 4, pp. 103-136
15. Groves BM, Droma T, Sutton JR, et al. (1993). Minimal hypoxic pulmonary hypertension in normal Tibetans at 3658 m. J Appl Physiol 74:312-318 (Pubitemid 23059762)
16. Hasegawa J, Wagner KF, Karp D, et al. (2004). Altered pulmonary vascular reactivity in mice with excessive erythrocytosis. Am J Respir Crit Care Med 169:829-835 (Pubitemid 38402459)
17. Hecht HH, Kuida H, Lange RL, Horne JL, and Brown AM. (1962). Brisket disease. Am J Med 32:171-183
18. Hoit BD, Dalton ND, Ezurum SC, Laskowski D, Strohl KP, Beall CM. (2005). Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders. J Appl Physiol 99:1796-1801 (Pubitemid 41547177)
19. Höhne C, Pickerodt PA, Francis RC, Boemke W, Swenson ER. (2007). Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol 292:L178-184 (Pubitemid 46103442)
20. Huez S, Faoro V, Vachiery JL, Unger P, Martinot JB, Naeije R. (2007). Images in cardiovascular medicine. High-Altitudeinduced right-heart failure. Circulation 115:e308-309
21. Huez S, Faoro V, Guénard H, Martinot JB, Naeije R. (2009). Echocardiographic and tissue Doppler imaging of cardiac adaptation to high altitude in native highlanders versus acclimatized lowlanders. Am J Cardiol 103:1605-1609
22. Hurtado A. (1964). Animals in high altitude: Resident man Handbook of Physiology (sect 4, vol1). Washington DC: Am Physiol Soc pp. 843-860
23. La Gerche A, MacIsaac AL, Burns AT, et al. (2010). Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function at exercise. J Appl Physiol 109:1307-1317
24. Lalande S, Yerly P, Faoro V, Naeije R. (2012). Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals. J Physiol 590: 4279-4288
25. Leon-Velarde F, Maggiorini M, Reeves JT, et al. (2005). Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol 6:147-157 (Pubitemid 41386664)
26. Leon-Velarde F, and Richalet JP. (2007). Respiratory control in residents at high altitude: Physiology and pathophysiology. High Alt Med Biol 7:125-137
27. Linehan JH, Haworth ST, Nelin LD, Krenz GS, Dawson CA. (1992). A simple distensible model for interpreting pulmonary vascular pressure-flow curves. J Appl Physiol 73:987-994
28. Lockhart A, Zelter M, Mensch-Dechene J, et al. (1976). Pressureflow-Volume relationships in pulmonary circulation of normal highlanders. J Appl Physiol 41:449-456
29. Macarlupu JL, Buvry A, Morel OE, Leon-Velarde F, Richalet JP, Favret F. (2006). Time course of ventilatory acclimatisation to hypoxia in a model of anemic transgenic mice. Respir Physiol Neurobiol 153:14-22 (Pubitemid 44107821)
30. Maggiorini M, Leon-Velarde F. (2003). High-Altitude pulmonary hypertension: A pathophysiological entity to different diseases. Eur Respir J 22:1019-1025 (Pubitemid 37540658)
31. Maignan M, Privat C, Leon-Velarde F, Richalet JP, Pham I. (2008). Pulmonary pressure and cardiac function in chronic mountain sickness patients. Chest 135:499-504
32. Manier G, Guenard H, Castaing Y, Varene N, Vargas E. (1988) Pulmonary gas exchange in Andean natives with excessive polycythemia. Effect of hemodilution. J Appl Physiol 65:2107-2117 (Pubitemid 19012316)
33. McLaughlin VV, Archer SL, Badesch DB, et al. (2009). ACCF/ AHA 2009 Expert Consensus Document on Pulmonary Hypertension. A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association. Circulation 119:2250-2294
34. Motley HL, Cournand A, WerköL, Himmelstein A, Dresdale D. (1947). The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150:315-320
35. Naeije R, Huez S, Lamotte M, et al. (2010). Pulmonary artery pressure limits exercise capacity at high altitudes. Eur Respir J 36:1049-1055
36. Naeije R. (2011). Pro: Hypoxic pulmonary vasoconstriction is a limiting factor for exercise capacity at high altitude. High Alt Med Biol 12:309-312
37. Naeije R, Chesler N. (2012). Pulmonary circulation at exercise. Compr Physiol 2:711-741
38. Naeye RL. (1962). Hypoxemia, effects on pulmonary vascular bed. Med Thoracalis 19:302-309
39. Pavelescu A, Vanderpool R, Vachiery JL, Grunig E, and Naeije R. (2012). Echocardiography of pulmonary vascular function in asymptomatic carriers of BMPR2 mutations. Eur Respir J 40:1287-1289.
40. Pavelescu A, Faoro V, Guenard H, et al. (2013). Pulmonary vascular reserve and exercise capacity, at sea level and at high altitude. High Alt Med Biol 14:19-26
41. Pei SX, Chen XJ, Si Ren BZ, et al. (1989). Chronic mountain sickness in Tibet. Q J Med 266:555-574 (Pubitemid 19182274)
42. Penaloza D, and Arias-Stella J. (2007). The heart and pulmonary circulation at high altitudes: Healthy highlanders and chronic mountain sickness. Circulation 115:1132-1146 (Pubitemid 46673174)
43. Sime F, Banchero N, Penaloza D, et al. (1963). Pulmonary hypertension in children born and living at high altitudes. Am J Cardiol. 11:143-149
44. Penaloza D, and Sime F. (1971). Chronic cor pulmonale due to loss of acclimatization (chronic mountain sickness). Am J Med 50:728-743
45. Plata R, Cornejo A, Arratia C, et al. (2002) Angiotensin-convertingenzyme inhibition therapy in altitude polycythaemia: A prospective randomised trial. Lancet 359:663-666 (Pubitemid 34203766)
46. Reeves JT, Groves BM, Sutton JR, et al. (1987). Operation Everest II: Preservation of cardiac function at extreme altitude. J Appl Physiol 63:531-539 (Pubitemid 17161953)
47. Reeves JT, Linehan JH, and Stenmark KR. (2005). Distensibility of the normal human lung circulation during exercise. Am J Physiol Lung Cell Mol Physiol 288:L419-425 (Pubitemid 40229506)
48. Richalet JP, Rivera M, Bouchet P, et al. (2005) Acetazolamide: A treatment for chronic mountain sickness. Am J Respir Crit Care Med 172:1427-1433 (Pubitemid 43069816)
49. Richalet JP, Rivera-Ch M, Maignan M, et al. (2008). Acetazolamide for Monge's disease: Efficiency and tolerance of 6-month treatment. Am J Respir Crit Care Med 177:1370-1376 (Pubitemid 351860915)
50. Rivera-Ch M, Leon-Velarde F, and Huicho L. (2007). Treatment of chronic mountain sickness: Critical reappraisal of an old problem. Respir Physiol Neurobiol 158:251-265 (Pubitemid 47440083)
51. Rotta Canepa AA, Hurtado A, Velasquez T, and Chavez R. (1956). Pulmonary circulation at sea level and at high altitude. J Appl Physiol 9:328-336
52. Sime F, Penaloza D, and Ruiz L. (1971). Bradycardia, increased cardiac output and reversal of pulmonary hypertension in altitude natives at sea level. Brit Heart J 33:647-657
53. Smith TG, Balanos GM, Croft QP, et al. (2008) The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. J Physiol 586:5999-6005
54. Smith TG, Talbot NP, Privat C, et al. (2009) Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: Two randomized controlled trials. JAMA 302: 1444-1450
55. Stuber T, Sartori C, Schwab M, et al. (2010). Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness. Chest 137:288-292
56. Sui GJ, Liu YH, and Cheng XS. (1988). Subacute infantile mountain sickness. J Pathol 155:161-170
57. Swenson ER. (1998). Carbonic anhydrase inhibitors and ventilation: A complex interplay of stimulation and suppression. Eur Respir J 12:1242-1247 (Pubitemid 29011408)
58. Teppema LJ, Balanos GM, Steinback CD, et al. (2007). Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia. Am J Respir Crit Care Med 175:277-281 (Pubitemid 46203132)
59. Villafuerte FC, Cardenas-Alayza R, Macarlupu JL, Monge CC, and Leon-Velarde F. (2007). Ventilatory response to acute hypoxia in transgenic mice overexpressing erythropoietin: Effect of an acclimatization to 3-week hypobaric hypoxia. Respir Physiol Neurobiol 158:243-250 (Pubitemid 47419510)
60. Vogel J, Kiessling I, Heinicke K, et al. (2003). Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity Blood 102:2278-2284 (Pubitemid 37122410)
61. Vogel JHK, Weaver WF, Rose RL, Blount SG, and Grover RF. (1962). Pulmonary hypertension on exertion in normal man living at 10150 feet (Leadville, Colorado) Med Thorac 19:269-285
62. Von Euler US, and Liljestrand G. (1946). Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301-320
63. Wagner PD, Gale GE, Moon RE, Torre-Bueno J, Stolpe BW, and Saltzman HA (1986). Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol 61:260-270 (Pubitemid 16055687)
64. Weissmann N, Manz D, Buchspies D, et al. (2005). Congenital erythropoietin over-expression causes ''anti-pulmonary hypertensive'' structural and functional changes in mice, both in normoxia and hypoxia. Thromb Haemost 94:630-638 (Pubitemid 41300862)
65. West JB. (2012). Concise clinical review: High altitude medicine. Am J Respir Crit Care Med 186:1229-1237
66. Winslow RM, Monge CC, Brown EG, et al. (1985). Effects of hemodilution on O2 transport in high-Altitude polycythemia. J Appl Physiol 59:1495-1502 (Pubitemid 16197415)
67. Whittaker SRF, and Winton FR. (1933). The apparent viscosity of blood flowing in the isolated hindlimb of the dog, and its variation with corpuscular concentration. J Physiol 78:339-369