Pulmonary circulation and gas exchange at exercise in Sherpas at high altitude

Journal of Applied Physiology

Volumn 116, Issue 7, 2014, Pages 919-926

  Faoro, Vitalie ^a   Huez, Sandrine ^b   Vanderpool, Rebecca ^a   Groepenhoff, Herman ^c   De Bisschop, Claire ^d   Martinot, Jean Benoît ^e   Lamotte, Michel ^b   Pavelescu, Adriana ^a   Guénard, Hervé ^f   Naeije, Robert ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITÉ DE POITIERS   (France)

^e Clinique & Maternite Sainte Elisabeth Namer   (Belgium)

^f BORDEAUX UNIVERSITY HOSPITAL   (France)

Author keywords

Highlanders; Lung diffusion; Pulmonary arterial pressure; Quechua; V

Indexed keywords

ACCLIMATIZATION; ADULT; ALTITUDE; ANOXIA; CHINA; COMPARATIVE STUDY; DOPPLER ECHOCARDIOGRAPHY; EPIDEMIOLOGY; ETHNOLOGY; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEMODYNAMICS; HUMAN; LUNG; LUNG CIRCULATION; LUNG DIFFUSION CAPACITY; LUNG FUNCTION TEST; LUNG GAS EXCHANGE; MALE; MIDDLE AGED; NEPAL; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PERU; PHENOTYPE; PULMONARY ARTERY; PULMONARY HYPERTENSION; YOUNG ADULT;

ACCLIMATIZATION; ADULT; ALTITUDE; ANOXIA; ECHOCARDIOGRAPHY, DOPPLER; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; LUNG; MALE; MIDDLE AGED; NEPAL; OXYGEN CONSUMPTION; PERU; PHENOTYPE; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY DIFFUSING CAPACITY; PULMONARY GAS EXCHANGE; RESPIRATORY FUNCTION TESTS; TIBET; YOUNG ADULT;

EID: 84896054001     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00236.2013     Document Type: Article

References (32)

1. Aguilaniu B, Maitre J, Glenet S, Gegout-Petit A, Guenard H. European reference equations for CO and NO lung transfer. Eur Respir J 31: 1091-1097, 2008.
2. Argiento P, Vanderpool RR, Mule M, Russo MG, D'Alto M, Bossone E, Chesler NC, Naeije R. Exercise stress echocardiography of the pulmonary circulation. Limits of normal and sex differences. Chest 142: 1158-1165, 2012.
3. Beall CM. Andean, Tibetan and Ethiopian patterns of adaptation to high-Altitude hypoxia. Integr Comp Physiol 46: 18-24, 2006.
4. Beall CM, Brittenham GM, Strohl KP, Blangero J, Williams-Blangero S, Goldstein MC, Decker MJ, Vargas E, Villena M, Soria R, Alarcon AM, Gonzales C. Hemoglobin concentration of high-Altitude Tibetans and Bolivian Aymara. Am J Phys Anthropol 106: 385-400, 1998.
5. Beall CM, Laskowski D, Erzurum SC. Nitric oxide in adaptation to altitude. Free Radic Biol Med 52: 1123-1134, 2012.
6. Beall CM, Strohl KP, Blangero J, Williams-Blangero S, Almasy LA, Decker MJ, Worthman CM, Goldstein MC, Vargas E, Villena M, Soria R, Alarcon AM, Gonzales C. Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives. Am J Phys Anthro-pol 104: 427-447, 1997.
7. Bossone E, D'Andrea A, D'Alto M, Citro R, Argiento P, Ferrara F, Cittadini A, Rubenfire M, Naeije R. Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis. J Am Soc Echocardiogr 26: 1-14, 2013.
8. Brutsaert TD. Do high-Altitude natives have an enhanced exercise performance at high altitude? Appl Physiol Nutr Metab 33: 582-592, 2008.
9. de Bisschop C, Martinot JB, Leurquin-Sterk G, Faoro V, Guénard H, Naeije R. Improvement in lung diffusion by endothelin A receptor blockade at high altitude. J Appl Physiol 112: 20-25, 2012.
10. Dempsey JA, Reddan WG, Birnbaum ML, Forster HV, Thoden JS, Grover R, Rankin J. Effects of acute through life-long hypoxic exposure on exercise pulmonary gas exchange. Respir Physiol 13: 62-89, 1971.
11. Forster RE. Diffusion of gases across the alveolar membrane In: Handbook of Physiology. The Respiratory System. Gas Exchange. Bethesda, MD: Am. Physiol. Soc., 1987, sect. 3, vol. IV, chapt. 5, p. 71-88.
12. Glénet SN, De Bisschop C, Vargas F, Guenard H. Deciphering the nitric oxide to carbon monoxide lung transfer ratio: physiological implications. J Physiol 582: 767-775, 2007.
13. Groepenhoff H, Overbeek MJ, Mulè M, van der Plas M, Argiento P, Villafuerte FC, Beloka S, Faoro V, Macarlupu JL, Guenard H, de Bisschop C, Martinot JB, Vanderpool R, Penaloza D, Naeije R. Exercise pathophysiology in patients with chronic mountain sickness. Chest 142: 877-884, 2012.
14. Grover RF, Wagner WW, McMurtry IF, Reeves JT. Pulmonary circulation. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 1, chapt. 4, p. 103-136.
15. Groves BM, Droma T, Sutton JR, McCullough RG, McCullough RE, Zhuang J, Rapmund G, Sun S, Janes C, Moore LG. Minimal hypoxic pulmonary hypertension in normal Tibetans at 3, 658 m. J Appl Physiol 74: 312-318, 1993.
16. Hoit BD, Dalton ND, Erzurum SC, Laskowski D, Strohl KP, Beall CM. Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders. J Appl Physiol 99: 1796-1801, 2005.
17. Huez S, Faoro V, Guénard H, Martinot JB, Naeije R. Echocardio-graphic and tissue Doppler imaging of cardiac adaptation to high altitude in native highlanders versus acclimatized lowlanders. Am J Cardiol 103: 1605-1609, 2009.
18. La Gerche A, MacIsaac AL, Burns AT, Mooney DJ, Inder WJ, Voigt JU, Heidbüchel H, Prior DL. Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function at exercise. J Appl Physiol 109: 1307-1317, 2010.
19. Lalande S, Yerly P, Faoro V, Naeije R. Pulmonary vascular distensi-bility predicts aerobic capacity in healthy individuals. J Physiol 590: 4279-4288, 2012.
20. Linehan JH, Haworth ST, Nelin LD, Krenz GS, Dawson CA. A simple distensible model for interpreting pulmonary vascular pressure-flow curves. J Appl Physiol 73: 987-994, 1992.
21. Lockhart A, Zelter M, Mensch-Dechene J, Antezana G, Paz-Zamora M, Vargas E, Coudert J. Pressure-flow-volume relationships in pulmonary circulation of normal highlanders. J Appl Physiol 41: 449-456, 1976.
22. Maignan M, Rivera-Ch M, Privat C, León-Velarde F, Richalet JP, Pham I. Pulmonary pressure and cardiac function in chronic mountain sickness patients. Chest 135: 499-504, 2009.
23. Manier G, Guenard H, Castaing Y, Varene N, Vargas E. Pulmonary gas exchange in Andean natives with excessive polycythemia-effect of hemodilution. J Appl Physiol 65: 2107-2117, 1988.
24. Moinard J, Guenard H. Determination of lung capillary blood volume and membrane diffusing capacity in patients with COLD using the NO-CO method. Eur Respir J 3: 318-322, 1990.
25. Naeije R, Huez S, Lamotte M, Retailleau K, Neupane S, Abramowicz D, Faoro V. Pulmonary artery pressure limits exercise capacity at high altitude. Eur Respir J 36: 1049-1055, 2010.
26. Pavelescu A, Faoro V, Guenard H, De Bisschop C, Martinot JB, Melot C, Naeije R. Pulmonary vascular reserve and exercise capacity, at sea level and at high altitude. High Alt Med Biol 14: 19-26, 2013.
27. Penazola D, Arias-Stella J. The heart and pulmonary circulation at high altitudes. Healthy highlanders and chronic mountain sickness. Circulation 115: 1132-1146, 2007.
28. Roughton FJW, Forster RE. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol 11: 290-302, 1957.
29. Simonson TS, McClain DA, Jorde LB, Prchal JT. Genetic determinants of Tibetan high-Altitude adaptation. Hum Genet 131: 527-33, 2012.
30. Stickland MK, Welsh RC, Petersen SR, Tyberg JV, Anderson WD, Jones RL, Taylor DA, Bouffard M, Haykowsky MJ. Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 100: 1895-901, 2006.
31. Wasserman K, Hansen JE, Sue DY, Whipp BJ. Principles of Exercise Testing and Interpretation (3rd Ed.). Baltimore, MD: Lippincott Williams & Wilkins, 1999, p. 143-164.
32. West JB. Concise clinical review: high altitude medicine. Am J Respir Crit Care Med 186: 1229-1237, 2012.