Dynamic cerebral autoregulation during and following acute hypoxia: Role of carbon dioxide

Journal of Applied Physiology

Volumn 114, Issue 9, 2013, Pages 1183-1190

  Querido, Jordan S ^a   Ainslie, Philip N ^b   Foster, Glen E ^a,b   Henderson, William R ^a   Halliwill, John R ^c   Ayas, Najib T ^a   Sheel, A William ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF OREGON   (United States)

Author keywords

Autonomic control; Cerebral autoregulation; Hypocapnia; Hypoxia

Indexed keywords

CARBON DIOXIDE; CARDIOVASCULAR AGENT; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ACUTE DISEASE; ADULT; ANOXIA; ARTICLE; AUTONOMIC CONTROL; BLOOD; BLOOD PRESSURE; BODY POSTURE; BRAIN CIRCULATION; CEREBRAL AUTOREGULATION; DRUG EFFECT; FEMALE; HOMEOSTASIS; HUMAN; HYPOCAPNIA; HYPOXIA; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; YOUNG ADULT;

AUTONOMIC CONTROL; CEREBRAL AUTOREGULATION; HYPOCAPNIA; HYPOXIA;

ACUTE DISEASE; ADULT; ANOXIA; BLOOD PRESSURE; CARBON DIOXIDE; CARDIOVASCULAR AGENTS; CEREBROVASCULAR CIRCULATION; FEMALE; HOMEOSTASIS; HUMANS; HYPOCAPNIA; MALE; NITROPRUSSIDE; PHENYLEPHRINE; POSTURE; YOUNG ADULT;

EID: 84878582418     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00024.2013     Document Type: Article

References (40)

1. Aaslid R, Lindegaard KF, Sorteberg W, Nornes H. Cerebral autoregulation dynamics in humans. Stroke 20:45-52, 1989. (Pubitemid 19040212)
2. Ainslie PN, Barach A, Murrell C, Hamlin M, Hellemans J, Ogoh S. Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. Am J Physiol Heart Circ Physiol 292:H976-H983, 2007.
3. Ainslie PN, Lucas SJ, Fan JL, Thomas KN, Cotter JD, Tzeng YC, Burgess KR. Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. J Appl Physiol 113:1058-1067, 2012.
4. Balfors EM, Franklin KA. Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med 150:1587-1591, 1994. (Pubitemid 24361731)
5. Cassaglia PA, Griffiths RI, Walker AM. Cerebral sympathetic nerve activity has a major regulatory role in the cerebral circulation in REM sleep. J Appl Physiol 106:1050-1056, 2009.
6. Claassen JA, Levine BD, Zhang R. Dynamic cerebral autoregulation during repeated squat-stand maneuvers. J Appl Physiol 106:153-160, 2009.
7. Foster GE, McKenzie DC, Milsom WK, Sheel AW. Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 567:689-699, 2005. (Pubitemid 41301062)
8. Fukuda Y, Sato A, Suzuki A, Trzebski A. Autonomic nerve and cardiovascular responses to changing blood oxygen and carbon dioxide levels in the rat. J Auton Nerv Syst 28:61-74, 1989. (Pubitemid 19276841)
9. Giller CA, Bowman G, Dyer H, Mootz L, Krippner W. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32:737-741; discussion 741-732, 1993.
10. Halliwill JR, Minson CT. Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans. J Appl Physiol 93:857-864, 2002. (Pubitemid 34919655)
11. Haubrich C, Wendt A, Diehl RR, Klotzsch C. Dynamic autoregulation testing in the posterior cerebral artery. Stroke 35:848-852, 2004. (Pubitemid 38419790)
12. Heistad DD, Kontos HA. Cerebral circulation. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 1, chapt. 5, p. 137-182.
13. Immink RV, Van Den Born BJ, Van Montfrans GA, Koopmans RP, Karemaker JM, Van Lieshout JJ. Impaired cerebral autoregulation in patients with malignant hypertension. Circulation 110:2241-2245, 2004. (Pubitemid 39372508)
14. Iwasaki K, Ogawa Y, Shibata S, Aoki K. Acute exposure to normobaric mild hypoxia alters dynamic relationships between blood pressure and cerebral blood flow at very low frequency. J Cereb Blood Flow Metab 27:776-784, 2007. (Pubitemid 46474615)
15. Johnston WE, De Witt DS, Vinten-Johansen J, Stump DA, Prough DS. Phenylephrine does not reduce cerebral perfusion during canine cardiopulmonary bypass. Anesth Analg 79:14-18, 1994. (Pubitemid 24203425)
16. Kasprowicz M, Czosnyka M, Czosnyka Z, Momjian S, Smielewski P, Juniewicz H, Pickard JD. Hysteresis of the cerebrospinal pressurevolume curve in hydrocephalus. Acta Neurochir Suppl (Wien) 86:529-532, 2003.
17. Lassen NA. Cerebral blood flow and oxygen consumption in man. Physiol Rev 39:183-238, 1959.
18. Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55:698-705, 2010.
19. Lusina SJ, Kennedy PM, Inglis JT, McKenzie DC, Ayas NT, Sheel AW. Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans. J Physiol 575:961-970, 2006. (Pubitemid 44323755)
20. Morgan BJ, Crabtree DC, Palta M, Skatrud JB. Combined hypoxia and hypercapnia evokes long-lasting sympathetic activation in humans. J Appl Physiol 79:205-213, 1995.
21. Nasr N, Traon AP, Czosnyka M, Tiberge M, Schmidt E, Larrue V. Cerebral autoregulation in patients with obstructive sleep apnea syndrome during wakefulness. Eur J Neurol 16:386-391, 2009.
22. Ogoh S, Nakahara H, Ainslie PN, Miyamoto T. The effect of oxygen on dynamic cerebral autoregulation: critical role of hypocapnia. J Appl Physiol 108:538-543, 2010.
23. Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol 96:1236-1242, 2004. (Pubitemid 38248707)
24. Poulin MJ, Robbins PA. Indexes of flow and cross-sectional area of the middle cerebral artery using Doppler ultrasound during hypoxia and hypercapnia in humans. Stroke 27:2244-2250, 1996. (Pubitemid 26427200)
25. Querido JS, Kennedy PM, Sheel AW. Hyperoxia attenuates muscle sympathetic nerve activity following isocapnic hypoxia in humans. J Appl Physiol 108:906-912, 2010.
26. Querido JS, Wehrwein EA, Hart EC, Charkoudian N, Henderson WR, Sheel AW. Baroreflex control of muscle sympathetic nerve activity as a mechanism for persistent sympathoexcitation following acute hypoxia in humans. Am J Physiol Regul Integr Comp Physiol 301:R1779-R1785, 2011.
27. Rudas L, Crossman AA, Morillo CA, Halliwill JR, Tahvanainen KU, Kuusela TA, Eckberg DL. Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine. Am J Physiol Heart Circ Physiol 276:H1691-H1698, 1999. (Pubitemid 29246558)
28. Sato K, Ogoh S, Hirasawa A, Oue A, Sadamoto T. The distribution of blood flow in the carotid and vertebral arteries during dynamic exercise in humans. J Physiol 589:2847-2856, 2011.
29. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31:1672-1678, 2000. (Pubitemid 30437522)
30. Smith KJ, Wong LE, Eves ND, Koelwyn GJ, Smirl JD, Willie CK, Ainslie PN. Regional cerebral blood flow distribution during exercise: influence of oxygen. Respir Physiol Neurobiol 184:97-105, 2012.
31. Tamisier R, Nieto L, Anand A, Cunnington D, Weiss JW. Sustained muscle sympathetic activity after hypercapnic but not hypocapnic hypoxia in normal humans. Respir Physiol Neurobiol 141:145-155, 2004. (Pubitemid 38887252)
32. Tsivgoulis G, Alexandrov AV. Cerebral autoregulation impairment during wakefulness in obstructive sleep apnea syndrome is a potential mechanism increasing stroke risk. Eur J Neurol 16:283-284, 2009.
33. Tzeng YC, Ainslie PN, Cooke WH, Peebles KC, Willie CK, Macrae BA, Smirl JD, Horsman HM, Rickards CA. Assessment of cerebral autoregulation: the quandary of quantification. Am J Physiol Heart Circ Physiol 303:H658-H671, 2012.
34. Tzeng YC, Willie CK, Atkinson G, Lucas SJ, Wong A, Ainslie PN. Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension 56:268-273, 2010.
35. Urbano F, Roux F, Schindler J, Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol 105:1852-1857, 2008.
36. Valdueza JM, Balzer JO, Villringer A, Vogl TJ, Kutter R, Einhaupl KM. Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. AJNR Am J Neuroradiol 18:1929-1934, 1997. (Pubitemid 30413737)
37. Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN. Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590:3261-3275, 2012.
38. Xie A, Skatrud JB, Puleo DS, Morgan BJ. Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 91:1555-1562, 2001. (Pubitemid 32900346)
39. Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol Heart Circ Physiol 274:H33-H241, 1998.
40. Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG, Levine BD. Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 106:1814-1820, 2002.