A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein

Journal of Controlled Release

Volumn 214, Issue , 2015, Pages 12-22

  Sánchez Vallecillo, María F ^a   Minguito De La Escalera, María M ^c   Aguirre, María V ^a   Ullio Gamboa, Gabriela V ^a   Palma, Santiago D ^a   González Cintado, Leticia ^c   Chiodetti, Ana L ^a   Soldano, Germán ^b   Morón, Gabriel ^a   Allemandi, Daniel A ^a   Ardavín, Carlos ^c   Pistoresi Palencia, María C ^a   Maletto, Belkys A ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b DEPARTAMENTO DE FISICOQUÍMICA   (Argentina)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Ascorbyl palmitate; Controlled release; Danger associated molecular patterns (DAMPs); Liquid crystal; Nanostructure; Vaccine adjuvant

Indexed keywords

ANTIGENS; IMMUNE SYSTEM; INFRARED DEVICES; LIQUID CRYSTALS; LIQUIDS; MAMMALS; NANOSTRUCTURES; PALMITIC ACID; PROTEINS; SELF ASSEMBLY; VACCINES;

ATTRACTIVE SYSTEMS; CONTROLLED RELEASE; INFLAMMATORY ACTIVITY; INFLAMMATORY RESPONSE; MOLECULAR PATTERNS; NEAR-INFRARED FLUORESCENT; SUSTAINED RELEASE; VACCINE ADJUVANTS;

ASCORBYL PALMITATE;

6 O ASCORBYL PALMITATE; ASCORBYL PALMITATE; CPG OLIGODEOXYNUCLEOTIDE; DNA; FLUORESCENT DYE; IMMUNOLOGICAL ADJUVANT; INFLAMMASOME; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; NANOMATERIAL; OVALBUMIN; SUBUNIT VACCINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; 6-O-PALMITOYLASCORBIC ACID; ANTIGEN; ASCORBIC ACID; DELAYED RELEASE FORMULATION; INTERLEUKIN DERIVATIVE; MYD88 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG EFFECT; DRUG RELEASE; IMMUNE RESPONSE; IMMUNIZATION; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION; LIQUID CRYSTAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUSTAINED RELEASE FORMULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; LEUKOCYTE; METABOLISM; PATHOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; ASCORBIC ACID; DELAYED-ACTION PREPARATIONS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKINS; LEUKOCYTES; LIQUID CRYSTALS; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; OVALBUMIN; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; VACCINES;

EID: 84937556463     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.07.008     Document Type: Article

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