Middle East Respiratory Syndrome: Knowledge to Date

Critical Care Medicine

Volumn 43, Issue 6, 2015, Pages 1283-1290

  Alsolamy, Sami ^a,b  

^a KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

Author keywords

communicable diseases; coronavirus; pneumonia; Saudi Arabia; severe acute respiratory syndrome; viral RNA

Indexed keywords

INTERFERON; LOPINAVIR; MYCOPHENOLIC ACID; RIBAVIRIN;

ANTIVIRAL THERAPY; CLINICAL FEATURE; CORONAVIRUS INFECTION; DISEASE SEVERITY; HUMAN; INFECTION CONTROL; LUNG DISEASE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; REVIEW; ADOLESCENT; ADULT; AGED; ANIMAL; CHILD; CORONAVIRUS INFECTIONS; FEMALE; INFANT; INTENSIVE CARE; MALE; MIDDLE AGED; ORGANIZATION AND MANAGEMENT; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PUBLIC HEALTH; PUBLIC HEALTH SERVICE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRAVEL; UNITED STATES; VERY ELDERLY; WORLD HEALTH ORGANIZATION; YOUNG ADULT; ZOONOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CENTERS FOR DISEASE CONTROL AND PREVENTION (U.S.); CHILD; CHILD, PRESCHOOL; CORONAVIRUS INFECTIONS; CRITICAL CARE; FEMALE; HUMANS; INFANT; INFECTION CONTROL; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PROGNOSIS; PUBLIC HEALTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRAVEL; UNITED STATES; WORLD HEALTH ORGANIZATION; YOUNG ADULT; ZOONOSES;

EID: 84937545382     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000966     Document Type: Review

References (65)

1. Hijawi B, Abdallat M, Sayaydeh A, et al: Novel coronavirus infections in Jordan, April 2012: Epidemiological findings from a retrospective investigation. East Mediterr Health J 2013; 19(Suppl 1):S12-S18
2. Zaki AM, van Boheemen S, Bestebroer TM, et al: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367:1814-1820
3. de Groot RJ, Baker SC, Baric RS, et al: Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group. J Virol 2013; 87:7790-7792
4. Drosten C, Günther S, Preiser W, et al: Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348:1967-1976
5. van der Hoek L: Human coronaviruses: What do they cause? Antivir Ther 2007; 12:651-658
6. van der Hoek L, Sure K, Ihorst G, et al: Croup is associated with the novel coronavirus NL63. PLoS Med 2005; 2:e240
7. Global alert and response. Revised interim case defnition for reporting to WHO-Middle East respiratory syndrome coronavirus (MERS-CoV) [Internet]. World Health Organization. Available at: http://www. who.int/csr/disease/coronavirus-infections/case-defnition/en/index. html. Accessed August 19, 2014
8. van Boheemen S, de Graaf M, Lauber C, et al: Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio 2012; 3:e00473-12
9. Drosten C, Seilmaier M, Corman VM, et al: Clinical features and viro-logical analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis 2013; 13:745-751
10. Guery B, Poissy J, el Mansouf L, et al; MERS-CoV study group: Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission. Lancet 2013; 381:2265-2272
11. Munster VJ, de Wit E, Fieldmann H: Pneumonia from human coronavirus in a macaque model. N Engl J Med 2013; 368:1560-1562
12. Hocke AC, Becher A, Knepper J, et al: Emerging human Middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs. Am J Respir Crit Care Med 2013; 188:882-886
13. Zhou J, Chu H, Li C, et al: Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of infammatory cytokines and chemokines in human macrophages: Implications for pathogenesis. J Infect Dis 2014; 209:1331-1342
14. Müller MA, Raj VS, Muth D, et al: Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replica-tive capability in mammalian cell lines. MBio 2012; 3:e00515-12
15. Hemida MG, Perera RA, Wang P, et al: Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013. Euro Surveill 2013; 18:20659
16. Azhar EI, El-Kafrawy SA, Farraj SA, et al: Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med 2014; 370:2499-2505
17. Reusken CB, Haagmans BL, Müller MA, et al: Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: A comparative serological study. Lancet Infect Dis 2013; 13:859-866
18. Memish ZA, Mishra N, Olival KJ, et al: Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerg Infect Dis 2013; 19:1819-1823
19. Corman VM, Ithete NL, Richards LR, et al: Rooting the phylogenetictree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat. J Virol 2014; 88:11297-11303
20. Cotten M, Watson SJ, Kellam P, et al: Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: A descriptive genomic study. Lancet 2013; 382:1993-2002
21. Memish ZA, Al-Tawfq JA, Assiri A, et al: Middle East respiratory syndrome coronavirus disease in children. Pediatr Infect Dis J 2014; 33:904-906
22. Cauchemez S, Fraser C, Van Kerkhove MD, et al: Middle East respiratory syndrome coronavirus: Quantifcation of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect Dis 2014; 14:50-56
23. Breban R, Riou J, Fontanet A: Interhuman transmissibility of Middle East respiratory syndrome coronavirus: Estimation of pandemic risk. Lancet 2013; 382:694-699
24. Assiri A, McGeer A, Perl TM, et al; KSA MERS-CoV Investigation Team: Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013; 369:407-416
25. Arabi YM, Arif AA, Balkhy HH, et al: Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med 2014; 160:389-397
26. WHO: Global alert and response. Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update [Internet]. 2014; 1-8 Available at: http://www.who.int/csr/disease/coronavirus- infections/MERS-CoV-Update-09-May-2014.pdf?ua=1. Accessed August 19, 2014
27. Memish ZA, Al-Tawfq JA, Makhdoom HQ, et al: Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: A prospective descriptive study. Clin Microbiol Infect 2014; 20:469-474
28. Nowotny N, Kolodziejek J: Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013. Euro Surveill 2014; 19:20781
29. Azhar EI, Hashem AM, El-Kafrawy SA, et al: Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient. MBio 2014; 5:e01450-14
30. Reusken CB, Farag EA, Jonges M, et al: Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014. Euro Surveill 2014; 19:pii:20829
31. van Doremalen N, Bushmaker T, Karesh WB, et al: Stability of Middle East respiratory syndrome coronavirus in milk. Emerg Infect Dis 2014; 20:1263-1264
32. Memish ZA, Al-Tawfq JA, Makhdoom HQ, et al: Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome. J Infectious Diseases 2014; 210:1590-1594
33. Sprenger M, Coulombier D: Middle East respiratory syndrome coronavirus-two years into the epidemic. Euro Surveill 2014; 19:20783
34. Almutairi SE, Boujenane I, Musaad A, et al: Non-genetic factors infuencing reproductive traits and calving weight in Saudi camels. Trop Anim Health Prod 2010; 42:1087-1092
35. van Doremalen N, Bushmaker T, Munster VJ: Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions. Euro Surveill 2013; 18
36. Al-Tawfq JA, Hinedi K, Ghandour J, et al: Middle East respiratory syndrome coronavirus: A case-control study of hospitalized patients. Clin Infect Dis 2014; 59:160-165
37. Assiri A, Al-Tawfq JA, Al-Rabeeah AA, et al: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study. Lancet Infect Dis 2013; 13:752-761
38. Saad M, Omrani AS, Baig K, et al: Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: A single-center experience in Saudi Arabia. Int J Infect Dis 2014; 29:301-306
39. World Health Organization: Novel coronavirus summary and literature update-as of 17 May 2013 [Internet]. Available at: http://www. who.int/csr/disease/coronavirus-infections/update-20130517/en/. Accessed August 22, 2014
40. Ajlan AM, Ahyad RA, Jamjoom LG, et al: Middle East respiratory syndrome coronavirus (MERS-CoV) infection: Chest CT findings. AJR Am J Roentgenol 2014; 203:782-787
41. Middle East respiratory syndrome coronavirus (MERS-CoV)-update Disease outbreak news. 16 January 2015. WHO. Available at: http://www.who.int/csr/don/16-january-2015-mers-Oman/en/. Accessed January 18, 2015
42. Corman VM, Eckerle I, Bleicker T, et al: Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill 2012; 17:pii:20285
43. Lu X, Whitaker B, Sakthivel SK, et al: Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus. J Clin Microbiol 2014; 52:67-75
44. WHO: Laboratory testing for Middle East respiratory syndrome coronavirus. Available at: http://www.who.int/csr/disease/coronavirus- infections/MERS-Lab-recos-16-Sept-2013.pdf. Accessed August 22, 2014
45. Corman VM, Ölschläger S, Wendtner CM, et al: Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA. J Clin Virol 2014; 60:168-171
46. Buchholz U, Müller MA, Nitsche A, et al: Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012. Euro Surveill 2013; 18:pii:20406
47. WHO: WHO-ISARIC joint MERS-CoV Outbreak Readiness Workshop: Clinical management and potential use of convalescent plasma 10-12 December 2013 [Internet]. Available at: http://www.who.int/csr/disease/coronavirus-infections/MERS-outbreak-readi-ness-workshop.pdf. Accessed August 22, 2014
48. Hung IF, To KK, Lee CK, et al: Convalescent plasma treatment reduced mortality in patients with severe pandemic infuenza A (H1N1) 2009 virus infection. Clin Infect Dis 2011; 52:447-456
49. Arabi YM: Anti-MERS-COV convalescent plasma therapy [Internet]. Clinical Trials.gov. Available at: http://clinicaltrials.gov/show/NCT02190799. Accessed August 22, 2014
50. Momattin H, Mohammed K, Zumla A, et al: Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy. Int J Infect Dis 2013; 17:e792-e798
51. Falzarano D, de Wit E, Martellaro C, et al: Inhibition of novel p coronavirus replication by a combination of interferon-a2b and ribavirin. Sci Rep 2013; 3:1686
52. Hart BJ, Dyall J, Postnikova E, et al: Interferon-p and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays. J Gen Virol 2014; 95:571-577
53. Falzarano D, de Wit E, Rasmussen AL, et al: Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques. Nat Med 2013; 19:1313-1317
54. Omrani AS, Saad MM, Baig K, et al: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: A retrospective cohort study. Lancet Infect Dis 2014; 14:1090-1095
55. Al-Tawfq JA, Momattin H, Dib J, et al: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: An observational study. Int J Infect Dis 2014; 20:42-46
56. Ying T, Du L, Ju TW, et al: Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies. J Virol 2014; 88:7796-7805
57. de Wilde AH, Jochmans D, Posthuma CC, et al: Screening of an FDA-approved compound library identifes four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother 2014; 58:4875-4884
58. Dyall J, Coleman CM, Hart BJ, et al: Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother 2014; 58:4885-4893
59. Eggimann P, Pittet D: Infection control in the ICU. Chest 2001; 120:2059-2093
60. Interim infection prevention and control recommendations for hospitalized patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [Internet]. cdc.gov. Available at: http://www.cdc. gov/coronavirus/mers/infection-prevention-control.html. Accessed August 22, 2014
61. Chung SJ, Ling ML, Seto WH, et al: Debate on MERS-CoV respiratory precautions: Surgical mask or N95 respirators? Singapore Med J 2014; 55:294-297
62. Zumla A, Hui DS: Infection control and MERS-CoV in health-care workers. Lancet 2014; 383:1869-1871
63. MOH: Infection prevention/control and management guidelines for patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection [Internet]. 2014; 1-39. Available at: http://www.moh.gov.sa/en/CCC/StaffRegulations/Corona/Documents/GuidelinesforCoronaPatients.pdf. Accessed January 1, 2015
64. Wray RJ, Becker SM, Henderson N, et al: Communicating with the public about emerging health threats: Lessons from the Pre-Event Message Development Project. Am J Public Health 2008; 98:2214-2222
65. Al-Tawfq JA, Assiri A, Memish ZA: Middle East respiratory syndrome novel corona MERS-CoV infection. Epidemiology and outcome update. Saudi Med J 2013; 34:991-994