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Volumn 8, Issue 4, 2015, Pages 702-707

Acute vagal nerve stimulation lowers α2 adrenoceptor availability: Possible mechanism of therapeutic action

Author keywords

Brain stimulation; Minipig; Noradrenaline; Positron emission tomography; Vagal nerve stimulation; Yohimbine

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; MONOAMINE; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG; YOHIMBINE; YOHIMBINE C 11; CARBON;

EID: 84937515768     PISSN: 1935861X     EISSN: 18764754     Source Type: Journal    
DOI: 10.1016/j.brs.2015.02.003     Document Type: Conference Paper
Times cited : (34)

References (54)
  • 1
    • 0027062798 scopus 로고
    • Inhibition of experimental seizures in canines by repetitive vagal stimulation
    • J. Zabara Inhibition of experimental seizures in canines by repetitive vagal stimulation Epilepsia 33 6 1992 1005 1012
    • (1992) Epilepsia , vol.33 , Issue.6 , pp. 1005-1012
    • Zabara, J.1
  • 2
    • 0033011096 scopus 로고    scopus 로고
    • Vagus nerve prolonged stimulation in cats: Effects on epileptogenesis (amygdala electrical kindling): Behavioral and electrographic changes
    • A. Fernandez-Guardiola, A. Martinez, A. Valdes-Cruz, V.M. Magdaleno-Madrigal, D. Martinez, and R. Fernandez-Mas Vagus nerve prolonged stimulation in cats: effects on epileptogenesis (amygdala electrical kindling): behavioral and electrographic changes Epilepsia 40 7 1999 822 829
    • (1999) Epilepsia , vol.40 , Issue.7 , pp. 822-829
    • Fernandez-Guardiola, A.1    Martinez, A.2    Valdes-Cruz, A.3    Magdaleno-Madrigal, V.M.4    Martinez, D.5    Fernandez-Mas, R.6
  • 3
    • 0037344999 scopus 로고    scopus 로고
    • Vagus nerve stimulation (VNS): Utility in neuropsychiatric disorders
    • M.S. George, A.J. Rush, H.A. Sackeim, and L.B. Marangell Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders Int J Neuropsychopharmacol 6 1 2003 73 83 10.1017/S1461145703003250
    • (2003) Int J Neuropsychopharmacol , vol.6 , Issue.1 , pp. 73-83
    • George, M.S.1    Rush, A.J.2    Sackeim, H.A.3    Marangell, L.B.4
  • 4
    • 24044505312 scopus 로고    scopus 로고
    • Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: A naturalistic study
    • A.J. Rush, H.A. Sackeim, L.B. Marangell, and et al. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study Biol Psychiatry 58 5 2005 355 363 10.1016/j.biopsych.2005.05.024 [pii]: S0006-3223(05)00619-0
    • (2005) Biol Psychiatry , vol.58 , Issue.5 , pp. 355-363
    • Rush, A.J.1    Sackeim, H.A.2    Marangell, L.B.3
  • 5
    • 1542315615 scopus 로고    scopus 로고
    • Vagus nerve stimulation (VNS) is effective in a rat model of antidepressant action
    • S.E. Krahl, S.S. Senanayake, A.E. Pekary, and A. Sattin Vagus nerve stimulation (VNS) is effective in a rat model of antidepressant action J Psychiatr Res 38 3 2004 237 240 10.1016/j.jpsychires.2003.11.005 [pii]: S0022395603001535
    • (2004) J Psychiatr Res , vol.38 , Issue.3 , pp. 237-240
    • Krahl, S.E.1    Senanayake, S.S.2    Pekary, A.E.3    Sattin, A.4
  • 6
    • 24044463171 scopus 로고    scopus 로고
    • A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    • M.S. George, A.J. Rush, L.B. Marangell, and et al. A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression Biol Psychiatry 58 5 2005 364 373 10.1016/j.biopsych.2005.07.028:[pii]: S0006-3223(05)00917-0
    • (2005) Biol Psychiatry , vol.58 , Issue.5 , pp. 364-373
    • George, M.S.1    Rush, A.J.2    Marangell, L.B.3
  • 7
    • 33745220053 scopus 로고    scopus 로고
    • VNS therapy in treatment-resistant depression: Clinical evidence and putative neurobiological mechanisms
    • C.B. Nemeroff, H.S. Mayberg, S.E. Krahl, and et al. VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms Neuropsychopharmacology 31 7 2006 1345 1355 10.1038/sj.npp.1301082 [pii]: 1301082
    • (2006) Neuropsychopharmacology , vol.31 , Issue.7 , pp. 1345-1355
    • Nemeroff, C.B.1    Mayberg, H.S.2    Krahl, S.E.3
  • 8
    • 0020416934 scopus 로고
    • Locus coeruleus projections to cortex: Topography, morphology and collateralization
    • S.E. Loughlin, S.L. Foote, and J.H. Fallon Locus coeruleus projections to cortex: topography, morphology and collateralization Brain Res Bull 9 1-6 1982 287 294
    • (1982) Brain Res Bull , vol.9 , Issue.1-6 , pp. 287-294
    • Loughlin, S.E.1    Foote, S.L.2    Fallon, J.H.3
  • 9
    • 0018836842 scopus 로고
    • Noradrenergic innervation of the adult rat hippocampal formation
    • R. Loy, D.A. Koziell, J.D. Lindsey, and R.Y. Moore Noradrenergic innervation of the adult rat hippocampal formation J Comp Neurol 189 4 1980 699 710 10.1002/cne.901890406
    • (1980) J Comp Neurol , vol.189 , Issue.4 , pp. 699-710
    • Loy, R.1    Koziell, D.A.2    Lindsey, J.D.3    Moore, R.Y.4
  • 10
    • 0031821408 scopus 로고    scopus 로고
    • Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation
    • S.E. Krahl, K.B. Clark, D.C. Smith, and R.A. Browning Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation Epilepsia 39 7 1998 709 714
    • (1998) Epilepsia , vol.39 , Issue.7 , pp. 709-714
    • Krahl, S.E.1    Clark, K.B.2    Smith, D.C.3    Browning, R.A.4
  • 11
    • 34247556375 scopus 로고    scopus 로고
    • Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine
    • S. Jakobsen, K. Pedersen, D.F. Smith, S.B. Jensen, O.L. Munk, and P. Cumming Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine J Nucl Med 47 12 2006 2008 2015 [pii]: 47/12/2008
    • (2006) J Nucl Med , vol.47 , Issue.12 , pp. 2008-2015
    • Jakobsen, S.1    Pedersen, K.2    Smith, D.F.3    Jensen, S.B.4    Munk, O.L.5    Cumming, P.6
  • 12
    • 58149402652 scopus 로고    scopus 로고
    • Interplay among catecholamine systems: Dopamine binds to alpha2-adrenergic receptors in birds and mammals
    • C.A. Cornil, and G.F. Ball Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals J Comp Neurol 511 5 2008 610 627 10.1002/cne.21861
    • (2008) J Comp Neurol , vol.511 , Issue.5 , pp. 610-627
    • Cornil, C.A.1    Ball, G.F.2
  • 13
    • 17144475031 scopus 로고    scopus 로고
    • Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states
    • M.J. Millan, A. Newman-Tancredi, V. Audinot, and et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states Synapse 35 2 2000 79 95 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X [pii]: 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X
    • (2000) Synapse , vol.35 , Issue.2 , pp. 79-95
    • Millan, M.J.1    Newman-Tancredi, A.2    Audinot, V.3
  • 14
    • 0032484715 scopus 로고    scopus 로고
    • [3H]RS79948-197 binding to human, rat, Guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine
    • S. Uhlen, M. Dambrova, J. Nasman, and et al. [3H]RS79948-197 binding to human, rat, Guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine Eur J Pharmacol 343 1 1998 93 101 [pii]: S0014-2999(97)01521-5
    • (1998) Eur J Pharmacol , vol.343 , Issue.1 , pp. 93-101
    • Uhlen, S.1    Dambrova, M.2    Nasman, J.3
  • 15
    • 84933672452 scopus 로고    scopus 로고
    • Stress-induced cognitive dysfunction: Hormone-neurotransmitter interactions in the prefrontal cortex
    • R.M. Shansky, and J. Lipps Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex Front Human Neurosc 7 2013 123 10.3389/fnhum.2013.00123
    • (2013) Front Human Neurosc , vol.7 , pp. 123
    • Shansky, R.M.1    Lipps, J.2
  • 16
    • 33646037988 scopus 로고    scopus 로고
    • Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain
    • D.F. Smith, S. Dyve, L. Minuzzi, and et al. Inhibition of [11C]mirtazapine binding by alpha2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain Synapse 59 8 2006 463 471 10.1002/syn.20262
    • (2006) Synapse , vol.59 , Issue.8 , pp. 463-471
    • Smith, D.F.1    Dyve, S.2    Minuzzi, L.3
  • 17
    • 84861880601 scopus 로고    scopus 로고
    • Amphetamine challenge decreases yohimbine binding to alpha 2 adrenoceptors in Landrace pig brain
    • A.M. Landau, D.J. Doudet, and S. Jakobsen Amphetamine challenge decreases yohimbine binding to alpha 2 adrenoceptors in Landrace pig brain Psychopharmacology 222 1 2012 155 163 10.1007/S00213-011-2632-6
    • (2012) Psychopharmacology , vol.222 , Issue.1 , pp. 155-163
    • Landau, A.M.1    Doudet, D.J.2    Jakobsen, S.3
  • 18
    • 84937520203 scopus 로고    scopus 로고
    • Quantification of [C]yohimbine binding to alpha adrenoceptors in rat brain in vivo
    • J.A. Phan, A.M. Landau, D.F. Wong, and et al. Quantification of [C]yohimbine binding to alpha adrenoceptors in rat brain in vivo J Cereb Blood Flow Metab 2015 10.1038/jcbfm.2014.225
    • (2015) J Cereb Blood Flow Metab
    • Phan, J.A.1    Landau, A.M.2    Wong, D.F.3
  • 19
    • 33750456540 scopus 로고    scopus 로고
    • Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat
    • R.W. Roosevelt, D.C. Smith, R.W. Clough, R.A. Jensen, and R.A. Browning Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat Brain Res 1119 1 2006 124 132 10.1016/j.brainres.2006.08.048 [pii]: S0006-8993(06)02447-4
    • (2006) Brain Res , vol.1119 , Issue.1 , pp. 124-132
    • Roosevelt, R.W.1    Smith, D.C.2    Clough, R.W.3    Jensen, R.A.4    Browning, R.A.5
  • 20
    • 80055118676 scopus 로고    scopus 로고
    • Basic surgical techniques in the Gottingen minipig: Intubation, bladder catheterization, femoral vessel catheterization, and transcardial perfusion
    • K.S. Ettrup, A.N. Glud, D. Orlowski, and et al. Basic surgical techniques in the Gottingen minipig: intubation, bladder catheterization, femoral vessel catheterization, and transcardial perfusion J Vis Exp 52 2011 10.3791/2652
    • (2011) J Vis Exp , Issue.52
    • Ettrup, K.S.1    Glud, A.N.2    Orlowski, D.3
  • 22
    • 0025127930 scopus 로고
    • Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects
    • J. Logan, J.S. Fowler, N.D. Volkow, and et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects J Cereb Blood Flow Metab 10 5 1990 740 747
    • (1990) J Cereb Blood Flow Metab , vol.10 , Issue.5 , pp. 740-747
    • Logan, J.1    Fowler, J.S.2    Volkow, N.D.3
  • 23
    • 42549126366 scopus 로고    scopus 로고
    • Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: Quantitative modeling and test-retest reproducibility
    • J. Hirvonen, J. Johansson, M. Teras, and et al. Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility J Cereb Blood Flow Metab 28 5 2008 1059 1069 10.1038/sj.jcbfm.9600607
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.5 , pp. 1059-1069
    • Hirvonen, J.1    Johansson, J.2    Teras, M.3
  • 24
    • 0031956318 scopus 로고    scopus 로고
    • Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects
    • G.L. Chan, J.E. Holden, A.J. Stoessl, and et al. Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects J Nucl Med 39 5 1998 792 797
    • (1998) J Nucl Med , vol.39 , Issue.5 , pp. 792-797
    • Chan, G.L.1    Holden, J.E.2    Stoessl, A.J.3
  • 25
    • 0032588607 scopus 로고    scopus 로고
    • Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects
    • G.L. Chan, J.E. Holden, A.J. Stoessl, and et al. Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects J Nucl Med 40 2 1999 283 289
    • (1999) J Nucl Med , vol.40 , Issue.2 , pp. 283-289
    • Chan, G.L.1    Holden, J.E.2    Stoessl, A.J.3
  • 26
    • 34547846251 scopus 로고    scopus 로고
    • Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    • R.B. Innis, V.J. Cunningham, J. Delforge, and et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 9 2007 1533 1539 10.1038/sj.jcbfm.9600493
    • (2007) J Cereb Blood Flow Metab , vol.27 , Issue.9 , pp. 1533-1539
    • Innis, R.B.1    Cunningham, V.J.2    Delforge, J.3
  • 27
    • 33646047272 scopus 로고    scopus 로고
    • Receptor occupancy in absence of reference region
    • A. Gjedde, and D.F. Wong Receptor occupancy in absence of reference region NeuroImage 11 2000 S48
    • (2000) NeuroImage , vol.11 , pp. S48
    • Gjedde, A.1    Wong, D.F.2
  • 28
    • 17444369079 scopus 로고    scopus 로고
    • Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat
    • D.A. Groves, E.M. Bowman, and V.J. Brown Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat Neurosci Lett 379 3 2005 174 179 10.1016/j.neulet.2004.12.055 [pii]: S0304-3940(05)00002-9
    • (2005) Neurosci Lett , vol.379 , Issue.3 , pp. 174-179
    • Groves, D.A.1    Bowman, E.M.2    Brown, V.J.3
  • 29
    • 33745947013 scopus 로고    scopus 로고
    • Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission
    • A.E. Dorr, and G. Debonnel Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission J Pharmacol Exp Ther 318 2 2006 890 898 10.1124/jpet.106.104166 [pii]: jpet.106.104166
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.2 , pp. 890-898
    • Dorr, A.E.1    Debonnel, G.2
  • 30
    • 70149083277 scopus 로고    scopus 로고
    • Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation
    • S. Manta, J. Dong, G. Debonnel, and P. Blier Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation J Psychiatry Neurosci 34 4 2009 272 280
    • (2009) J Psychiatry Neurosci , vol.34 , Issue.4 , pp. 272-280
    • Manta, S.1    Dong, J.2    Debonnel, G.3    Blier, P.4
  • 31
    • 84937536669 scopus 로고    scopus 로고
    • Evaluating NA release with C-11 yohimbine: Combined in vivo PET-microdialysis studies
    • D.J. Doudet, G. Wegener, S. Jakobsen, and et al. Evaluating NA release with C-11 yohimbine: combined in vivo PET-microdialysis studies J Cereb Blood Flow Metab 32 2012 S90 S91
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. S90-S91
    • Doudet, D.J.1    Wegener, G.2    Jakobsen, S.3
  • 32
    • 13244279638 scopus 로고    scopus 로고
    • Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex
    • P. Devoto, G. Flore, P. Saba, M. Fa, and G.L. Gessa Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex J Neurochem 92 2 2005 368 374 10.1111/j.1471-4159.2004.02866.x [pii]: JNC2866
    • (2005) J Neurochem , vol.92 , Issue.2 , pp. 368-374
    • Devoto, P.1    Flore, G.2    Saba, P.3    Fa, M.4    Gessa, G.L.5
  • 33
    • 1042301274 scopus 로고    scopus 로고
    • Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex
    • P. Devoto, G. Flore, L. Pira, G. Longu, and G.L. Gessa Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex J Neurochem 88 4 2004 1003 1009 [pii] 2239
    • (2004) J Neurochem , vol.88 , Issue.4 , pp. 1003-1009
    • Devoto, P.1    Flore, G.2    Pira, L.3    Longu, G.4    Gessa, G.L.5
  • 34
    • 0028819482 scopus 로고
    • Effect of noradrenergic lesions on subtypes of α2-adrenoceptors in rat brain
    • G.A. Ordway Effect of noradrenergic lesions on subtypes of α2-adrenoceptors in rat brain J Neurochem 64 3 1995 1118 1126 10.1046/j.1471-4159.1995.64031118.x
    • (1995) J Neurochem , vol.64 , Issue.3 , pp. 1118-1126
    • Ordway, G.A.1
  • 35
    • 0022618035 scopus 로고
    • Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain
    • A.C. Petrash, and D.B. Bylund Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain Life Sci 38 23 1986 2129 2137
    • (1986) Life Sci , vol.38 , Issue.23 , pp. 2129-2137
    • Petrash, A.C.1    Bylund, D.B.2
  • 36
    • 0032589266 scopus 로고    scopus 로고
    • α2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: Potential activation by dopamine
    • W. Zhang, V. Klimek, J.T. Farley, M.-Y. Zhu, and G.A. Ordway α2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine J Pharmacol Exp Ther 289 3 1999 1286 1292
    • (1999) J Pharmacol Exp Ther , vol.289 , Issue.3 , pp. 1286-1292
    • Zhang, W.1    Klimek, V.2    Farley, J.T.3    Zhu, M.-Y.4    Ordway, G.A.5
  • 37
    • 0015699218 scopus 로고
    • Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat
    • P.S. Arnold, R.J. Racine, and R.A. Wise Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat Exp Neurol 40 2 1973 457 470
    • (1973) Exp Neurol , vol.40 , Issue.2 , pp. 457-470
    • Arnold, P.S.1    Racine, R.J.2    Wise, R.A.3
  • 38
    • 0016140419 scopus 로고
    • Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats
    • M.E. Corcoran, H.C. Fibiger, J.A. McCaughran Jr., and J.A. Wada Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats Exp Neurol 45 1 1974 118 133
    • (1974) Exp Neurol , vol.45 , Issue.1 , pp. 118-133
    • Corcoran, M.E.1    Fibiger, H.C.2    McCaughran, Jr.J.A.3    Wada, J.A.4
  • 39
    • 0020190008 scopus 로고
    • Effect of norepinephrine depletion on dorsal hippocampus kindling in rats
    • D.C. McIntyre, and N. Edson Effect of norepinephrine depletion on dorsal hippocampus kindling in rats Exp Neurol 77 3 1982 700 704
    • (1982) Exp Neurol , vol.77 , Issue.3 , pp. 700-704
    • McIntyre, D.C.1    Edson, N.2
  • 41
    • 77954540861 scopus 로고    scopus 로고
    • Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats
    • J. Szyndler, P. Maciejak, D. Turzynska, A. Sobolewska, A. Bidzinski, and A. Plaznik Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats J Neural Transm 117 6 2010 707 718 10.1007/s00702-010-0414-7
    • (2010) J Neural Transm , vol.117 , Issue.6 , pp. 707-718
    • Szyndler, J.1    MacIejak, P.2    Turzynska, D.3    Sobolewska, A.4    Bidzinski, A.5    Plaznik, A.6
  • 42
    • 0030045648 scopus 로고    scopus 로고
    • The role of dopamine in epilepsy
    • M.S. Starr The role of dopamine in epilepsy Synapse 22 2 1996 159 194 10.1002/(SICI)1098-2396(199602)22:2<159::AID-SYN8>3.0.CO;2-C
    • (1996) Synapse , vol.22 , Issue.2 , pp. 159-194
    • Starr, M.S.1
  • 43
    • 29544438942 scopus 로고    scopus 로고
    • The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant
    • P.C. Jobe, and R.A. Browning The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant Epilepsy Behav 7 4 2005 602 619 10.1016/j.yebeh.2005.07.014
    • (2005) Epilepsy Behav , vol.7 , Issue.4 , pp. 602-619
    • Jobe, P.C.1    Browning, R.A.2
  • 44
    • 0037441824 scopus 로고    scopus 로고
    • Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression
    • G.A. Ordway, J. Schenk, C.A. Stockmeier, W. May, and V. Klimek Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression Biol Psychiatry 53 4 2003 315 323 [pii]: S0006322302017286
    • (2003) Biol Psychiatry , vol.53 , Issue.4 , pp. 315-323
    • Ordway, G.A.1    Schenk, J.2    Stockmeier, C.A.3    May, W.4    Klimek, V.5
  • 45
    • 16944362115 scopus 로고    scopus 로고
    • Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
    • V. Klimek, C. Stockmeier, J. Overholser, and et al. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression J Neurosci 17 21 1997 8451 8458
    • (1997) J Neurosci , vol.17 , Issue.21 , pp. 8451-8458
    • Klimek, V.1    Stockmeier, C.2    Overholser, J.3
  • 46
    • 0028284060 scopus 로고
    • Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims
    • A.M. Gonzalez, J. Pascual, J.J. Meana, and et al. Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims J Neurochem 63 1 1994 256 265
    • (1994) J Neurochem , vol.63 , Issue.1 , pp. 256-265
    • Gonzalez, A.M.1    Pascual, J.2    Meana, J.J.3
  • 48
    • 0026548740 scopus 로고
    • Alpha 2-adrenoceptors in the brain of suicide victims: Increased receptor density associated with major depression
    • J.J. Meana, F. Barturen, and J.A. Garcia-Sevilla Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression Biol Psychiatry 31 5 1992 471 490
    • (1992) Biol Psychiatry , vol.31 , Issue.5 , pp. 471-490
    • Meana, J.J.1    Barturen, F.2    Garcia-Sevilla, J.A.3
  • 49
    • 0028168589 scopus 로고
    • Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide
    • G.A. Ordway, P.S. Widdowson, K.S. Smith, and A. Halaris Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide J Neurochem 63 2 1994 617 624
    • (1994) J Neurochem , vol.63 , Issue.2 , pp. 617-624
    • Ordway, G.A.1    Widdowson, P.S.2    Smith, K.S.3    Halaris, A.4
  • 50
    • 0345391014 scopus 로고    scopus 로고
    • Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides
    • J.A. Garcia-Sevilla, P.V. Escriba, A. Ozaita, and et al. Up-regulation of immunolabeled alpha2A-adrenoceptors, Gi coupling proteins, and regulatory receptor kinases in the prefrontal cortex of depressed suicides J Neurochem 72 1 1999 282 291
    • (1999) J Neurochem , vol.72 , Issue.1 , pp. 282-291
    • Garcia-Sevilla, J.A.1    Escriba, P.V.2    Ozaita, A.3
  • 51
    • 3242774471 scopus 로고    scopus 로고
    • Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims
    • P.V. Escriba, A. Ozaita, and J.A. Garcia-Sevilla Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims Neuropsychopharmacology 29 8 2004 1512 1521 10.1038/sj.npp.1300459 [pii]: 1300459
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1512-1521
    • Escriba, P.V.1    Ozaita, A.2    Garcia-Sevilla, J.A.3
  • 52
    • 0027452671 scopus 로고
    • Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography
    • G.B. Kovachich, A. Frazer, and C.E. Aronson Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography Neuropsychopharmacology 8 1 1993 57 65
    • (1993) Neuropsychopharmacology , vol.8 , Issue.1 , pp. 57-65
    • Kovachich, G.B.1    Frazer, A.2    Aronson, C.E.3
  • 54
    • 84937517745 scopus 로고    scopus 로고
    • In vivo alpha2 adrenoceptor binding demonstrates a prolonged effect of electroconvulsive therapy on noradrenergic function in Gottingen minipigs
    • A.M. Landau, G. Wegener, A. Alstrup, and et al. In vivo alpha2 adrenoceptor binding demonstrates a prolonged effect of electroconvulsive therapy on noradrenergic function in Gottingen minipigs Int J Neuropsychopharmacol 15 S1 2012 234 235
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.S1 , pp. 234-235
    • Landau, A.M.1    Wegener, G.2    Alstrup, A.3


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