Carbetocin at Cesarean delivery for labour arrest: a sequential allocation trial to determine the effective dose;Administration de carbétocine lors d’un accouchement par césarienne pour arrêt de la progression du travail: une étude d’attribution séquentielle afin de déterminer la dose efficace

Canadian Journal of Anesthesia

Volumn 62, Issue 8, 2015, Pages 866-874

  Nguyen Lu, Nhathien ^a   Carvalho, Jose Carlos Almeida ^a,b   Farine, Dan ^b   Seaward, Gareth ^b   Ye, Xiang Y ^a   Balki, Mrinalini ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CARBETOCIN; CARBOPROST; CARDIOVASCULAR AGENT; ERGOMETRINE; OXYTOCIN; PHENYLEPHRINE; TROPONIN T; OXYTOCIC AGENT;

ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ARTICLE; BRADYCARDIA; CESAREAN SECTION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE SEQUENCE; DRUG INFUSION; DRUG MEGADOSE; DRUG TREATMENT FAILURE; DYSPNEA; ELECTIVE SURGERY; EPIDURAL ANESTHESIA; FEMALE; FLUSHING; HEADACHE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE EXTRASYSTOLE; HUMAN; HYPERTENSION; HYPOTENSION; INTRAOPERATIVE PERIOD; LABOR ARREST; LABOR COMPLICATION; LABOR MANAGEMENT; MONOMORPHIC VENTRICULAR TACHYCARDIA; NAUSEA; OBSTETRICIAN; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECOMMENDED DRUG DOSE; SINUS ARRHYTHMIA; TACHYCARDIA; THORAX PAIN; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; UTERUS FUNCTION; UTERUS TONE; VOMITING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; LABOR; MIDDLE AGED; MUSCLE HYPOTONIA; OBSTETRIC ANESTHESIA; OBSTETRIC LABOR COMPLICATIONS; PREGNANCY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; UTERUS; YOUNG ADULT;

ADOLESCENT; ADULT; ANESTHESIA, EPIDURAL; ANESTHESIA, OBSTETRICAL; CESAREAN SECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LABOR, OBSTETRIC; MIDDLE AGED; MUSCLE HYPOTONIA; OBSTETRIC LABOR COMPLICATIONS; OXYTOCICS; OXYTOCIN; PREGNANCY; UTERUS; YOUNG ADULT;

EID: 84937515169     PISSN: 0832610X     EISSN: 14968975     Source Type: Journal    
DOI: 10.1007/s12630-015-0375-2     Document Type: Article

References (33)

1. World Health Organization, Unicef, UNFPA, The World Bank. Trends in Maternal Mortality 1990 to 2008: Estimates developed by WHO, Unicef, UNFPA and The World Bank. Geneva: World Health Organization 2010. Available from URL: http://www.who.int/reproductivehealth/publications/monitoring/9789241500265/en/ (accessed February 2015).
2. Cantwell R, Clutton-Brock T, Cooper G, et al. Saving Mother’s Lives: reviewing maternal deaths to make motherhood safer: 2006-2008.The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG 2011; 118(Suppl. 1): 1-203.
3. Public Health Agency of Canada. Maternal Mortality in Canada. Available from URL: http://www.phac-aspc.gc.ca/rhs-ssg/ (accessed February 2015).
4. Bateman BT, Berman MF, Riley LE, Leffert LR. The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth Analg 2010; 110: 1368-73.
5. Lutomski JE, Byrne BM, Devane D, Greene RA. Increasing trends in atonic postpartum hemorrhage in Ireland: an 11-year population based cohort study. BJOG 2012; 119: 306-14.
6. Dyer RA, van Dyk D, Dresner A. The use of uterotonic drugs during caesarean section. Int J Obstet Anesth 2010; 19: 313-9.
7. Ryden G, Sjoholm I. Half-life of oxytocin in blood of pregnant and non-pregnant women. Acta Endocrinol (Copenh) 1969; 61: 425-31.
8. Barth T, Krejci I, Kupkova B, Jost K. Pharmacology of cyclic analogues of deamino-oxytocin not containing a disulphide bond (carba analogues). Eur J Pharmacol 1973; 24: 183-8.
9. Su LL, Chong YS, Samuel M. Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2012; 4: CD005457.
10. Leduc D, Senikas V, Lalonde AB, et al. Active management of the third stage of labor: prevention and treatment of postpartum hemorrhage. J Obstet Gynaecol Can 2009; 31: 980-93.
11. Peters NC, Duvekot JJ. Carbetocin for the prevention of postpartum hemorrhage: a systematic review. Obstet Gynecol Surv 2009; 64: 129-35.
12. Cordovani D, Balki M, Farine D, Seaward G, Carvalho JC. Carbetocin at elective cesarean delivery: a randomized controlled trial to determine the effective dose. Can J Anesth 2012; 59: 751-7.
13. Anandakrishnan S, Balki M, Farine D, Seaward G, Carvalho JC. Carbetocin at elective cesarean delivery: a randomized controlled trial to determine the effective dose - part 2. Can J Anesth 2013; 60: 1054-60.
14. Khan M, Balki M, Ahmed I, Farine D, Seaward G, Carvalho JC. Carbetocin at elective cesarean delivery: a sequential allocation trial to determine the minimum effective dose. Can J Anesth 2014; 61: 242-8.
15. Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107: 45-50.
16. Allen VM, Yudin MH, Bouchard M, et al. Management of group B streptoccal bacteruria in pregnancy. J Obstet Gynaecol Can 2012; 34: 482-6.
17. Liston R, Sawchuck D, Young D; Society of Obstetrics and Gynaecologists of Canada;British Columbia Perinatal Health Program. Fetal health surveillance: antepartum and intrapartum consensus guideline. J Obstet Gynaecol Can 2007; 29 (9 Suppl 4): S3-56.
18. Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P; Canadian Hypertensive Disorders of Pregnancy Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can 2014; 36: 416-38.
19. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gynecol 2004; 104(5 Pt 1): 1005-10.
20. Pace NL, Stylianou MP. Advances in and limitations of up-and-down methodology: a précis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology 2007; 107: 144-52.
21. Brownlee KA, Hodges JL Jr, Rosenblatt M. The up-and-down method with small samples. J Am Stat Assoc 1953; 48: 262-77.
22. Stylianou M, Flournoy N. Dose finding using the biased coin up-and-down design and isotonic regression. Biometrics 2002; 58: 171-7.
23. Robinson C, Schumann R, Zhang P, Young RC. Oxytocin induced desensitization of the oxytocin receptor. Am J Obstet Gynecol 2003; 188: 497-502.
24. Phaneuf S, Rodriguez Linares B, TambyRaja RL, MacKenzie IZ, Lopez Bernal A. Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour. J Reprod Fertil 2000; 120: 91-7.
25. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H. Structure and expression of human oxytocin receptor. Nature 1992; 356: 526-9.
26. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 1984; 150: 734-41.
27. Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y, Balki M. Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci 2009; 16: 501-8.
28. Balki M, Erik-Soussi M, Kingdom J, Carvalho JC. Oxytocin pretreatment attenuates oxytocin-induced contractions in human myometrium in vitro. Anesthesiology 2013; 119: 552-61.
29. Balki M, Cole N, Erik-Soussi M, Kingdom J, Carvalho JC. Carbetocin vs oxytocin: in-vitro contractions in oxytocin pre-treated myometrium. Can J Anesth 2012; 59(Suppl): Abstract (1344730).
30. Moertl MG, Friedrich S, Kraschl J, Wadsack C, Lang U, Schlemback D. Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial. BJOG 2011; 118: 1349-56.
31. Rosseland LA, Hauge TH, Grindheim G, Stubhaug A, Langesaeter E. Changes in blood pressure and cardiac output during cesarean delivery: the effects of oxytocin and carbetocin compared with placebo. Anesthesiology 2013; 119: 541-51.
32. Balki M, Dhumne S, Kasodekar S, Kingdom J, Windrim R, Carvalho JC. Oxytocin-ergometrine co-administration does not reduce blood loss at caesarean delivery for labour arrest. BJOG 2008; 115: 579-84.
33. Soltani H. Uterine Massage for Preventing Postpartum Haemorrhage: RHL Commentary (last revised: 1 April 2010). The WHO Reproductive Health Library; Geneva: World Health Organization. Available from URL: http://apps.who.int/rhl/pregnancy_childbirth/childbirth/3rd_stage/Cd006431_soltanih_com/en/ (accessed February 2015).