Oxytocin pretreatment attenuates oxytocin-induced contractions in human myometrium in vitro

Anesthesiology

Volumn 119, Issue 3, 2013, Pages 552-561

  Balki, Mrinalini ^a   Erik Soussi, Magda ^a   Kingdom, John ^b   Carvalho, Jose C A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN; OXYTOCIC AGENT;

ADULT; CESAREAN SECTION; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; ELECTIVE SURGERY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MYOMETRIUM; PRIORITY JOURNAL; REGIONAL ANESTHESIA; UTERUS CONTRACTILITY; UTERUS CONTRACTION; AREA UNDER THE CURVE; DOSE RESPONSE; DRUG EFFECTS; PREGNANCY; TIME;

ADULT; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IN VITRO TECHNIQUES; OXYTOCICS; OXYTOCIN; PREGNANCY; TIME FACTORS; UTERINE CONTRACTION;

EID: 84883219187     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318297d347     Document Type: Conference Paper

References (22)

1. Gimpl G, Fahrenholz F: The oxytocin receptor system: Structure, function, and regulation. Physiol Rev 2001; 81: 629-83 (Pubitemid 32267075)
2. Zingg HH, Laporte SA: The oxytocin receptor. Trends Endocrinol Metab 2003; 14: 222-7 (Pubitemid 36841480)
3. Robinson C, Schumann R, Zhang P, Young RC: Oxytocininduced desensitization of the oxytocin receptor. Am J Obstet Gynecol 2003; 188: 497-502
4. Phaneuf S, Asbóth G, Carrasco MP, Europe-Finner GN, Saji F, Kimura T, Harris A, López Bernal A: The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA. J Endocrinol 1997; 154: 7-18 (Pubitemid 27304342)
5. Phaneuf S, Asbóth G, Carrasco MP, Liñares BR, Kimura T, Harris A, Bernal AL: Desensitization of oxytocin receptors in human myometrium. Hum Reprod Update 1998; 4: 625-33 (Pubitemid 29041476)
6. Phaneuf S, Rodríguez Liñares B, TambyRaja RL, MacKenzie IZ, López Bernal A: Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour. J Reprod Fertil 2000; 120: 91-7
7. Bugg GJ, Stanley E, Baker PN, Taggart MJ, Johnston TA: Outcomes of labours augmented with oxytocin. Eur J Obstet Gynecol Reprod Biol 2006; 124: 37-41 (Pubitemid 43020925)
8. Crane JMG, Young DC: Metanalysis of low dose versus high dose oxytocin for labour induction. J Obstet Gynaecol Can 1998; 20: 1215-23
9. Grotegut CA, Paglia MJ, Johnson LN, Thames B, James AH: Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. Am J Obstet Gynecol 2011; 204:56.e1-6
10. Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y, Balki M: Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentrationdependent but not time-dependent manner. Reprod Sci 2009; 16: 501-8
11. Balki M, Cristian AL, Kingdom J, Carvalho JC: Oxytocin pretreatment of pregnant rat myometrium reduces the efficacy of oxytocin but not of ergonovine maleate or prostaglandin F 2 alpha. Reprod Sci 2010; 17: 269-77
12. Balki M, Kanwal N, Erik-Soussi M, Kingdom J, Carvalho JC: Contractile efficacy of various prostaglandins in pregnant rat myometrium pretreated with oxytocin. Reprod Sci 2012; 19: 968-75
13. Caldeyro-Barcia R, Sica-Blanco Y, Poseiro JJ, Gonzalez Panizza V, Mendez-Bauer C, Fielitz C, Alvarez H, Pose SV, Hendricks CH: A quantitative study of the action of synthetic oxytocin on the pregnant human uterus. J Pharmacol Exp Ther 1957; 121: 18-31
14. Burton MJ, Dziuk HE, Fahning ML, Zemjanis R: Myometrial activity during natural and dexamethasone-induced parturition in the cow. Am J Vet Res 1987; 48: 37-44 (Pubitemid 17224556)
15. Smith MP, Ayad VJ, Mundell SJ, McArdle CA, Kelly E, López Bernal A: Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells. Mol Endocrinol 2006; 20: 379-88 (Pubitemid 43152511)
16. Carvalho JC, Balki M, Kingdom J, Windrim R: Oxytocin requirements at elective cesarean delivery: A dose-finding study. Obstet Gynecol 2004; 104(5 Pt 1): 1005-10 (Pubitemid 40458764)
17. Balki M, Ronayne M, Davies S, Fallah S, Kingdom J, Windrim R, Carvalho JC: Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107: 45-50
18. Seitchik J, Amico J, Robinson AG, Castillo M: Oxytocin augmentation of dysfunctional labor. IV. Oxytocin pharmacokinetics. Am J Obstet Gynecol 1984; 150: 225-8 (Pubitemid 14000342)
19. Kuwabara Y, Takeda S, Mizuno M, Sakamoto S: Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine. Arch Gynecol Obstet 1987; 241: 13-23 (Pubitemid 18043232)
20. Rahm VA, Hallgren A, Högberg H, Hurtig I, Odlind V: Plasma oxytocin levels in women during labor with or without epidural analgesia: A prospective study. Acta Obstet Gynecol Scand 2002; 81: 1033-9
21. Feldman R, Weller A, Zagoory-Sharon O, Levine A: Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci 2007; 18: 965-70
22. Perry RL, Satin AJ, Barth WH, Valtier S, Cody JT, Hankins GD: The pharmacokinetics of oxytocin as they apply to labor induction. Am J Obstet Gynecol 1996; 174: 1590-3 (Pubitemid 26165283)