Carbetocin at elective Cesarean delivery: A sequential allocation trial to determine the minimum effective dose

Canadian Journal of Anesthesia

Volumn 61, Issue 3, 2014, Pages 242-248

  Khan, Mubeen ^a   Balki, Mrinalini ^a   Ahmed, Iram ^a   Farine, Dan ^b   Seaward, Gareth ^b   Carvalho, Jose C A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBETOCIN; UTEROTONIC AGENT;

ADULT; ARTICLE; BRADYCARDIA; CESAREAN SECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSPNEA; ELECTIVE SURGERY; FEMALE; HEADACHE; HOT FLUSH; HUMAN; HYPERTENSION; HYPOTENSION; MAJOR CLINICAL STUDY; NAUSEA; OPERATIVE BLOOD LOSS; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; THORAX PAIN; UTERUS CONTRACTION; VOMITING;

ADULT; ANESTHESIA, SPINAL; CESAREAN SECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; OXYTOCICS; OXYTOCIN; PREGNANCY; UTERINE CONTRACTION;

EID: 84896735361     PISSN: 0832610X     EISSN: 14968975     Source Type: Journal    
DOI: 10.1007/s12630-013-0082-9     Document Type: Article

References (28)

1. Joseph KS, Rouleau J, Kramer MS, et al. Investigation of an increase in postpartum haemorrhage in Canada. BJOG 2007; 114: 751-9. (Pubitemid 46788638)
2. Callaghan WM, Kuklina EV, Berg CJ. Trends in postpartum hemorrhage: United States, 1994-2006. Am J Obstet Gynecol 2010; 202: 353.e1-6.
3. World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Geneva: WHO; 2012 Available from: http://apps.who.int/iris/bitstream/10665/75411/1/9789241548502-eng.pdf (accessed October 2013).
4. Nordstrom L, Fogelstam K, Fridman G, Larsson A, Rydhstroem H. Routine oxytocin in the third stage of labour: a placebo controlled randomised trial. Br J Obstet Gynaecol 1997; 104: 781-6. (Pubitemid 27319453)
5. Ryden G, Sjoholm I. Half-life of oxytocin in blood of pregnant and non-pregnant women. Acta Endocrinol (Copenh) 1969; 61: 425-31.
6. Chard T, Boyd NR, Forsling ML, McNeilly AS, Landon J. The development of a radioimmunoassay for oxytocin: the extraction of oxytocin from plasma, and its measurement during parturition in human and goat blood. J Endocrinol 1970; 48: 223-34.
7. Dyer RA, Butwick AJ, Carvalho B. Oxytocin for labour and caesarean delivery: implications for the anaesthesiologist. Curr Opin in Anaesthesiol 2011; 24: 255-61.
8. Dansereau J, Joshi AK, Helewa ME, et al. Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section. Am J Obstet Gynecol 1999; 180(3 Pt 1): 670-6. (Pubitemid 29149145)
9. Svanstrom MC, Biber B, Hanes M, Johansson G, Naslund U, Balfors EM. Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during caesarean section. Br J Anaesth 2008; 100: 683-9. (Pubitemid 351774375)
10. Engstrom T, Barth T, Melin P, Vilhardt H. Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation. Eur J Pharmacol 1998; 355: 203-10. (Pubitemid 28404703)
11. Sweeney G, Holbrook AM, Levine M, et al. Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, in nonpregnant women. Curr Ther Res 1990; 47: 528-40. (Pubitemid 20104063)
12. Attilakos G, Psaroudakis D, Ash J, et al. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG 2010; 117: 929-36.
13. Borruto F, Treisser A, Comparetto C. Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial. Arch Gynecol Obstet 2009; 280: 707-12.
14. Su LL, Chong YS, Samuel M. Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2012; 4: CD005457.
15. Leduc D, Senikas V, Lalonde AB, et al. Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage. J Obstet Gynaecol Can 2009; 31: 980-93.
16. Cordovani D, Balki M, Farine D, Seaward G, Carvalho JC. Carbetocin at elective cesarean delivery: a randomized controlled trial to determine the effective dose. Can J Anesth 2012; 59: 751-7.
17. Anandakrishnan S, Balki M, Farine D, Seaward G, Carvalho JC. Carbetocin at elective cesarean delivery: a randomized controlled trial to determine the effective dose, part 2. Can J Anesth 2013;. DOI:10.1007/s12630-013-0028-2.
18. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose finding study. Obstet Gynecol 2004; 104: 1005-10. (Pubitemid 40458764)
19. Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107: 45-50.
20. Shook PR, Schultz JR, Reynolds JD, Barbara P, Spahn TE, DeBalli P. Estimating blood loss for cesarean section - how accurate are we? Anesthesiology 2003; 98(Supp 1): SOAP A2 (abstract).
21. Pace NL, Stylianou MP. Advances in and limitations of up-anddown methodology: a précis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology 2007; 107: 144-52. (Pubitemid 46987830)
22. Stylianou M, Flournoy N. Dose finding using the biased coin up-and-down design and isotonic regression. Biometrics 2002; 58: 171-7. (Pubitemid 34194501)
23. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B. Minimum effective bolus dose of oxytocin during elective caesarean delivery. Br J Anaesth 2010; 104: 338-43.
24. Hunter DJ, Schulz P, Wassenaar W. Effect of carbetocin, a long acting oxytocin analogue on the postpartum uterus. Clin Pharmacol Ther 1992; 52: 60-7.
25. Atke A, Vilhardt H. Uterotonic activity and myometrial receptor affinity of 1-deamino-1-carba-2-tyrosine(O-methyl)-oxytocin. Acta Endocrinol (Copenh) 1987; 115: 155-60. (Pubitemid 17072406)
26. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H. Structure and expression of a human oxytocin receptor. Nature 1992; 356: 526-9.
27. Peters NC, Duvekot JJ. Carbetocin for the prevention of postpartum hemorrhage: a systematic review. Obstet Gynecol Surv 2009; 64: 129-35.
28. Boucher M, Horbray GL, Griffin P, et al. Double-blind, randomized comparison of the effect of carbetocin and oxytocin on intraoperative blood loss and uterine tone of patients undergoing cesarean section. J Perinatol 1998; 18: 202-7. (Pubitemid 128451702)