Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: A randomised trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 118, Issue 11, 2011, Pages 1349-1356

  Moertl, M G ^a,b   Friedrich, S ^a   Kraschl, J ^a   Wadsack, C ^a   Lang, U ^a   Schlembach, D ^a,c  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Clinical Center   (Austria)

^c Prenatal Medicine Munich   (Germany)

Author keywords

Caesarean section; carbetocin; cardiovascular effects; oxytocin; postpartum haemorrhage

Indexed keywords

CARBETOCIN; OXYTOCIN;

ABNORMAL SENSATION; ADULT; ARTICLE; BRADYCARDIA; CARDIOVASCULAR EFFECT; CESAREAN SECTION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; DYSPNEA; FEMALE; HEADACHE; HEART RATE; HEMODYNAMICS; HOT FLUSH; HUMAN; INTRAPARTUM CARE; MAJOR CLINICAL STUDY; NAUSEA; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REBOUND; RECOMMENDED DRUG DOSE; SIDE EFFECT; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; WARM SENSATION;

ADULT; CESAREAN SECTION; DOUBLE-BLIND METHOD; FEMALE; HEMODYNAMICS; HUMANS; INJECTIONS, INTRAVENOUS; OXYTOCICS; OXYTOCIN; POSTPARTUM HEMORRHAGE; PREGNANCY; STIMULATION, CHEMICAL; TIME FACTORS; UTERINE CONTRACTION;

EID: 80052775567     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2011.03022.x     Document Type: Article

References (21)

1. Carroli G, Cuesta C, Abalos E, Gulmezoglu AM,. Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol 2008; 22: 999-1012.
2. Chong YS, Su LL, Arulkumaran S,. Current strategies for the prevention of postpartum haemorrhage in the third stage of labour. Curr Opin Obstet Gynecol 2004; 16: 143-5.
3. Cotter AM, Ness A, Tolosa JE,. Prophylactic oxytocin for the third stage of labour. Cochrane Database Syst Rev 2001; 4:CD001808.
4. National Collaborating Centre for Women's and Children's Health Commissioned by the National Institute for Clinical Excellence. Caesarean Section. London: RCOG Press; 2004.
5. Sweeney G, Holbrook AM, Levine M, Yip M, Alfredsson K, Cappi S, et al., Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, in nonpregnant women. Curr Ther Res 1990; 47: 528-40. (Pubitemid 20104063)
6. Attilakos G, Psaroudakis D, Ash J, Buchanan R, Winter C, Donald F, et al., Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG 2010; 117: 929-36.
7. Pinder AJ, Dresner M, Calow C, Shorten GD, O'Riordan J, Johnson R,. Haemodynamic changes caused by oxytocin during caesarean delivery under spinal anaesthesia. Int J Obstet Anesth 2002; 11: 156-9. (Pubitemid 34836288)
8. Thomas JS, Koh SH, Cooper GM,. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean delivery. Br J Anaesth 2007; 98: 116-9. (Pubitemid 44896761)
9. Svanström MC, Biber B, Hanes M, Johansson G, Näslund U, BØ¥lfors EM,. Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during Caesarean section. Br J Anaesth 2008; 100: 683-9. (Pubitemid 351774375)
10. Langesaeter E, Rosseland LA, Stubhaug A,. Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients. Br J Anaesth 2009; 103: 260-2.
11. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B,. Minimum effective bolus dose of oxytocin during elective Caesarean delivery. Br J Anaesth 2010; 104: 338-43.
12. Boucher M, Horbay GL, Griffin P, Deschamps Y, Desjardins C, Schulz M, et al., Double-blind, randomized comparison of the effect of carbetocin and oxytocin on intraoperative blood loss and uterine tone of patients undergoing cesarean delivery. J Perinatol 1998; 18: 202-7. (Pubitemid 128451702)
13. Dansereau J, Joshi AK, Helewa ME, Doran TA, Lange IR, Luther ER, et al., Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean delivery. Am J Obstet Gynecol 1999; 180: 670-6. (Pubitemid 29149145)
14. Boucher M, Nimrod CA, Tawagi GF, Meeker TA, Rennicks White RE, Varin J,. Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery: a double-blind randomized trial. J Obstet Gynaecol Can 2004; 26: 481-8.
15. Su LL, Chong YS, Samuel M,. Oxytocin agonists for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2007; 3: CD005457.
16. Schulz KF, Altman DG, Moher D,. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med 2010; 8: 18.
17. Fortin J, Habenbacher W, Heller A, Hacker A, Grüllenberger R, Innerhofer J, et al., Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement. Comput Biol Med 2006; 36: 1185-203. (Pubitemid 44286781)
18. Mörtl MG, Ulrich D, Pickel KI, Klaritsch P, Schaffer M, Flotzinger D, et al., Changes in haemodynamic and autonomous nervous system parameters measured non-invasively throughout normal pregnancy. Eur J Obstet Gynecol Reprod Biol 2009; 144S: S179-83.
19. Kubicek WG, Karnegis JN, Patterson RP, Witsoe DA, Mattson RH,. Development and evaluation of an impedance cardiac output system. Aerosp Med 1996; 37: 1208-12.
20. Atke A, Vilhardt H,. Uterotonic activity and myometrial receptor affinity of 1-deamino-1-carba-2-tyrosine(O-methyl)-oxytocin. Acta Endocrinol (Copenh) 1987; 115: 155-60. (Pubitemid 17072406)
21. Hunter DJ, Schulz P, Wassenaar W,. Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus. Clin Pharmacol Ther 1992; 52: 60-7.