Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 15, 2015, Pages 4132-4138

  Demizu, Yosuke ^a   Misawa, Takashi ^a   Nagakubo, Takaya ^a,b   Kanda, Yasunari ^a   Okuhira, Keiichiro ^a   Sekino, Yuko ^a   Naito, Mikihiko ^a   Kurihara, Masaaki ^a,b  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Estrogen receptor; Helical peptide; Protein protein interaction; Transcriptional inhibitor

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ARGININE; DEXTRO PERM 4 PEPTIDE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ANTAGONIST; HEPTAARGININE; M1 PERM 4 PEPTIDE; M2 PERM 4 PEPTIDE; PEPTIDE; PERM 1 PEPTIDE; PERM 1 R7 PEPTIDE; PERM 3 PEPTIDE; PERM 3 R7 PEPTIDE; PERM 5 PEPTIDE; PERM 5 R7 PEPTIDE; PROTEIN PS2; R7 PERM 3 PEPTIDE; SRC 1 PEPTIDE; SRC 1 R7 PEPTIDE; UNCLASSIFIED DRUG; YR7 PEPTIDE; 2-AMINOISOBUTYRIC ACID; PRESENILIN 2; PSEN2 PROTEIN, HUMAN;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LEVEL; CELL TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISULFIDE BOND; DOWN REGULATION; DRUG DESIGN; DRUG STRUCTURE; GENE EXPRESSION REGULATION; IC50; INHIBITION KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN INTERACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CIRCULAR DICHROISM; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PRECLINICAL STUDY; PROCEDURES; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SOLID PHASE SYNTHESIS; SYNTHESIS;

AMINOISOBUTYRIC ACIDS; ARGININE; CIRCULAR DICHROISM; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; HUMANS; PEPTIDES; PRESENILIN-2; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPS; PROTEIN STABILITY; RECEPTORS, ESTROGEN; SOLID-PHASE SYNTHESIS TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84937513774     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.06.067     Document Type: Article

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