GATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon

Molecular and Cellular Biology

Volumn 32, Issue 17, 2012, Pages 3392-3402

  Beuling, Eva ^a   Aronson, Boaz E ^a,b   Tran, Luc M D ^a   Stapleton, Kelly A ^a   ter Horst, Ellis N ^a   Vissers, Laurens A T M ^a   Verzi, Michael P ^c,d,f   Krasinski, Stephen D ^a,e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e TUFTS UNIVERSITY   (United States)

^f Life Sciences Building Rutgers University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; TRANSCRIPTION FACTOR GATA 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; COLON; COLON ADENOCARCINOMA; CONTROLLED STUDY; CRYPT CELL; ELECTRON MICROSCOPY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GOBLET CELL; HORMONE RELEASE; IMMUNOFLUORESCENCE; L CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR DOWN REGULATION; SECRETORY CELL; STAINING;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; COLON; EPITHELIAL CELLS; FEMALE; GATA6 TRANSCRIPTION FACTOR; GENE DELETION; GENE EXPRESSION REGULATION; GOBLET CELLS; INTESTINAL MUCOSA; MALE; MICE;

MUS;

EID: 84866272340     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00070-12     Document Type: Article

References (38)

1. Al-azzeh, ED, Fegert P, Blin N, Gott P. 2000. Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2. Biochim. Biophys. Acta 1490:324-332.
2. Ayanbule F, Belaguli NS, Berger DH. 2011. GATA factors in gastrointestinal malignancy. World J. Surg. 35:1757-1765.
3. Bachmann O, et al. 2004. The Na+/H exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G125-G133.
4. Barker N, et al. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003-1007.
5. Belaguli NS, et al. 2010. GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression. Neoplasia 12:856-865.
6. Bernstein BE, et al. 2005. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120:169-181.
7. Beuling E, et al. 2011. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology 140:1219-1229.e2.
8. Beuling E, et al. 2008. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev. Biol. 322:179-189.
9. Bosse T, et al. 2006. Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol. Cell. Biol. 26:9060-9070.
10. Brewer AC, Sparks EC, Shah AM. 2006. Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: role of GATAbinding factor(s). Free Radic. Biol. Med. 40:260-274.
11. Divine JK, et al. 2004. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G1086-G1099.
12. Dusing MR, Florence EA, Wiginton DA. 2003. High-level activation by a duodenum-specific enhancer requires functional GATA binding sites. Am. J. Physiol. Gastrointest. Liver Physiol. 284:G1053-G1065.
13. Fabrikant JI. 1987. Adaptation of cell renewal systems under continuous irradiation. Health Phys. 52:561-570.
14. Haveri H, et al. 2008. Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol. 8:9. doi:10.1186/1471-230X-8-9.
15. He HH, et al. 2010. Nucleosome dynamics define transcriptional enhancers. Nat. Genet. 42:343-347.
16. Heintzman ND, et al. 2009. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459:108-112.
17. Hoogerwerf WA, et al. 1996. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. Am. J. Physiol. 270:G29-G41.
18. Huggon IC, et al. 1997. Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut. Biochim. Biophys. Acta 1353:98-102.
19. Karam SM. 1999. Lineage commitment and maturation of epithelial cells in the gut. Front. Biosci. 4:D286-D298.
20. Katz JP, et al. 2002. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129: 2619-2628.
21. Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ. 2001. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G69-G84.
22. Liu T, et al. 2011. Cistrome: an integrative platform for transcriptional regulation studies. Genome Biol. 12:R83. doi:10.1186/gb-2011-12-8-r83.
23. Nicol JW, Helt GA, Blanchard SG, Jr, Raja A, Loraine AE. 2009. The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets. Bioinformatics 25:2730-2731.
24. Patient RK, McGhee JD. 2002. The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12:416-422.
25. Ren CY, Akiyama Y, Miyake S, Yuasa Y. 2004. Transcription factor GATA-5 selectively up-regulates mucin gene expression. J. Cancer Res. Clin. Oncol. 130:245-252.
26. Schonhoff S, et al. 2005. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Mol. Cell. Biol. 25:4189-4199.
27. Schultheis PJ, et al. 1998. Targeted disruption of the murine Na+/H exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J. Clin. Invest. 101:1243-1253.
28. Schultheis PJ, et al. 1998. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H exchanger. Nat. Genet. 19:282-285.
29. Shureiqi I, et al. 2007. The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer. FASEB J. 21:743-753.
30. Sodhi CP, Li J, Duncan SA. 2006. Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev. Biol. 6:19. doi: 10.1186/1471-213X-6-19.
31. Tom BH, et al. 1976. Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 12:180-191.
32. Upchurch BH, Fung BP, Rindi G, Ronco A, Leiter AB. 1996. Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice. Development 122:1157-1163.
33. Valente AJ, et al. 2008. Regulation of NOX1 expression by GATA, HNF-1alpha, and Cdx transcription factors. Free Radic. Biol. Med. 44:430-443.
34. van der Sluis M, et al. 2004. The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem. Biophys. Res. Commun. 325:952-960.
35. van Wering HM, et al. 2004. Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G899-G909.
36. Velcich A, et al. 2002. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295:1726-1729.
37. Verzi MP, et al. 2010. Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev. Cell 19:713-726.
38. Zhang Y, et al. 2008. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9:R137. doi:10.1186/gb-2008-9-9-r137.