Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 29, 2015, Pages 8922-8928

  Weissman, Irving L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Botryllus schlosseri; Cancer; Evolution; Natural selection; Stem cell competition

Indexed keywords

CD47 ANTIGEN;

ADAPTIVE IMMUNITY; ALLELE; APOPTOSIS; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL CLONE; CELL DIFFERENTIATION; CELL MIGRATION; CELL RENEWAL; CELL SURVIVAL; CHIMERA; COLONIAL SPECIES; DNA POLYMORPHISM; EPIGENETICS; GENE LOCUS; GENOTYPE; GERMLINE STEM CELL; LEUKEMIA; MACROPHAGE; NATURAL SELECTION; NONHUMAN; PARABIOSIS; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMATIC CELL; STEM CELL NICHE; UPREGULATION; ANIMAL; CYTOLOGY; DISEASE COURSE; ECOSYSTEM; GENETIC POLYMORPHISM; GENETIC SELECTION; GENETICS; GERM CELL; HUMAN; METABOLISM; MOUSE; NEOPLASM; ORGANOGENESIS; PATHOLOGY; SPECIES DIFFERENCE; STEM CELL;

BOTRYLLUS; BOTRYLLUS SCHLOSSERI; MUS; UROCHORDATA;

ANIMALS; ANTIGENS, CD47; CHIMERA; CLONE CELLS; DISEASE PROGRESSION; ECOSYSTEM; GENOTYPE; GERM CELLS; HUMANS; LEUKEMIA; MACROPHAGES; MICE; NEOPLASMS; ORGANOGENESIS; PARABIOSIS; PHAGOCYTOSIS; POLYMORPHISM, GENETIC; SELECTION, GENETIC; SPECIES SPECIFICITY; STEM CELLS;

EID: 84937457955     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505464112     Document Type: Article

References (33)

1. Weissman IL (2000) Stem cells: Units of development, units of regeneration, and units in evolution. Cell 100(1):157-168.
2. Laird DJ, Weissman IL (2004) Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol 273(2):185-194.
3. Scofield VL, Schlumpberger JM, West LA, Weissman IL (1982) Protochordate allorecognition is controlled by a MHC-like gene system. Nature 295(5849):499-502.
4. Voskoboynik A, et al. (2013) Identification of a colonial chordate histocompatibility gene. Science 341(6144):384-387.
5. Voskoboynik A, et al. (2013) The genome sequence of the colonial chordate, Botryllus schlosseri. eLife 2:e00569.
6. Schaller CE, et al. (2008) Expression of Aire and the early wave of apoptosis in spermatogenesis. J Immunol 180(3):1338-1343.
7. Stoner DS, Weissman IL (1996) Somatic and germ cell parasitism in a colonial ascidian: Possible role for a highly polymorphic allorecognition system. Proc Natl Acad Sci USA 93(26):15254-15259.
8. Stoner DS, Rinkevich B, Weissman IL (1999) Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates. Proc Natl Acad Sci USA 96(16): 9148-9153.
9. Rinkevich B, Weissman IL (1987) A long-term study on fused subclones in the ascidian Botryllus schlosseri: The resorption phenomenon (Protochordata: Tunicata). J Zool 213(4):717-734.
10. Laird DJ, De Tomaso AW, Weissman IL (2005) Stem cells are units of natural selection in a colonial ascidian. Cell 123(7):1351-1360.
11. Buss LW (1982) Somatic cell parasitism and the evolution of somatic tissue compatibility. Proc Natl Acad Sci USA 79(17):5337-5341.
12. Ueno H, Weissman IL (2006) Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. Dev Cell 11(4):519-533.
13. Ueno H, Turnbull BB, Weissman IL (2009) Two-step oligoclonal development of male germ cells. Proc Natl Acad Sci USA 106(1):175-180.
14. Carmell MA, et al. (2007) MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell 12(4):503-514.
15. Mathis D, Benoist C (2009) Aire. Annu Rev Immunol 27:287-312.
16. Akashi K, Kondo M, Weissman IL (1998) Two distinct pathways of positive selection for thymocytes. Proc Natl Acad Sci USA 95(5):2486-2491.
17. Domen J, Weissman IL (2003) Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2. Exp Hematol 31(7):631-639.
18. Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P (1997) An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16(9):2262-2270.
19. Rossi DJ, Jamieson CH, Weissman IL (2008) Stems cells and the pathways to aging and cancer. Cell 132(4):681-696.
20. Beerman I, et al. (2010) Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA 107(12):5465-5470.
21. Weissman I (2005) Stem cell research: Paths to cancer therapies and regenerative medicine. JAMA 294(11):1359-1366.
22. Miyamoto T, Weissman IL, Akashi K (2000) AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci USA 97(13):7521-7526.
23. Jamieson CH, et al. (2004) Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351(7):657-667.
24. Majeti R, et al. (2009) Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci USA 106(9):3396-3401.
25. Pang WW, et al. (2013) Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc Natl Acad Sci USA 110(8):3011-3016.
26. Jan M, et al. (2012) Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Science Transl Med 4(149):149ra118.
27. Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R (2014) Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA 111(7):2548-2553.
28. Lagasse E, Weissman IL (1994) bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med 179(3):1047-1052.
29. Jaiswal S, et al. (2009) CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138(2):271-285.
30. Majeti R, et al. (2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138(2):286-299.
31. Chao MP, Majeti R, Weissman IL (2012) Programmed cell removal: A new obstacle in the road to developing cancer. Nat Rev Cancer 12(1):58-67.
32. Willingham SB, et al. (2012) The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci USA 109(17):6662-6667.
33. Steinbeck J (1955) The Log of the Sea of Cortez (Penguin Books, New York), pp 136-137.