A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways

American Journal of Human Genetics

Volumn 97, Issue 1, 2015, Pages 125-138

  Soave, David ^a,b   Corvol, Harriet ^c,d   Panjwani, Naim ^b   Gong, Jiafen ^b   Li, Weili ^a,b   Boëlle, Pierre Yves ^d,e   Durie, Peter R ^a,f   Paterson, Andrew D ^a,b   Rommens, Johanna M ^b,g   Strug, Lisa J ^a,b   Sun, Lei ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c ARMAND TROUSSEAU HOSPITAL   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e HÔPITAL SAINT ANTOINE   (France)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

complex traits; cystic fibrosis; GxE interaction; GxG interaction; HbA1c level; multivariate model; pathway; type 1 diabetes; variance tests

Indexed keywords

HEMOGLOBIN A1C; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

ACTIN FILAMENT; APICAL MEMBRANE; ARTICLE; BINDING SITE; CELL MEMBRANE; DISEASE SEVERITY; ENDOSOME; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CODE; GENETIC MODEL; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JOINT LOCATION SCALE TEST; LUNG FIBROSIS; LUNG FUNCTION; PDZ DOMAIN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STOICHIOMETRY; COMPUTER SIMULATION; CYSTIC FIBROSIS; DIABETES MELLITUS; EVALUATION STUDY; GENETICS; METABOLISM; PROCEDURES;

CELL MEMBRANE; COMPUTER SIMULATION; CYSTIC FIBROSIS; DIABETES COMPLICATIONS; GENETIC ASSOCIATION STUDIES; HUMANS; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SODIUM-HYDROGEN ANTIPORTER;

EID: 84937440003     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2015.05.015     Document Type: Article

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