An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia

Biomaterials

Volumn 65, Issue , 2015, Pages 126-139

  Dash, Biraja C ^a   Thomas, Dilip ^b   Monaghan, Michael ^c   Carroll, Oliver ^b   Chen, Xizhe ^b   Woodhouse, Kimberly ^d   O'Brien, Timothy ^b   Pandit, Abhay ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

Angiogenesis; Critical limb ischemia; Elastin like polypeptide; Gene therapy; Hollow spheres; Inflammation

Indexed keywords

BLOOD; BLOOD VESSELS; CELL CULTURE; GENE THERAPY; GENE TRANSFER; GLYCOPROTEINS; PATHOLOGY; PATIENT TREATMENT;

ANGIOGENESIS; CRITICAL LIMB ISCHEMIA; ELASTIN-LIKE POLYPEPTIDES; HOLLOW SPHERE; INFLAMMATION;

ELASTIN;

ELASTIN; ELASTIN LIKE POLYPEPTIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBROBLAST GROWTH FACTOR; INTERLEUKIN 10; PLATELET DERIVED GROWTH FACTOR B; UNCLASSIFIED DRUG; VASCULOTROPIN; IL10 PROTEIN, HUMAN; NOS3 PROTEIN, HUMAN; PEPTIDE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; CROSS LINKING; DOSE RESPONSE; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; COMPLICATION; GENE THERAPY; GENE TRANSFER; GENETICS; HINDLIMB; ISCHEMIA; MALE; METABOLISM; PATHOLOGY; PLASMID; THERAPEUTIC USE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANIMALS; CELL LINE; ELASTIN; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-10; ISCHEMIA; MALE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDES; PLASMIDS;

EID: 84937428890     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.06.037     Document Type: Article

References (47)

1. Ouriel K. Peripheral arterial disease. Lancet 2001, 358:1257-1264.
2. Tulsyan N., Ouriel K., Kashyap V.S. Emerging drugs in peripheral arterial disease. Expert Opin. Emerg. Drugs 2006, 11:75-90.
3. Eliason J.L., Wakefield T.W. Metabolic consequences of acute limb ischemia and their clinical implications. Semin. Vasc. Surg. 2009, 22:29-33.
4. Lavu M., Gundewar S., Lefer D.J. Gene therapy for ischemic heart disease. J.Mol. Cell. Cardiol. 2011, 50:742-750.
5. Thomas D., Fontana G., Chen X., Sanz-Nogues C., Zeugolis D.I., Dockery P., et al. Ashape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells. Biomaterials 2014, 35:8757-8766.
6. Cao R., Brakenhielm E., Pawliuk R., Wariaro D., Post M.J., Wahlberg E., et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat. Med. 2003, 9:604-613.
7. Cao Y. Molecular mechanisms and therapeutic development of angiogenesis inhibitors. Adv. Cancer Res. 2008, 100:113-131.
8. Cao Y. Tumor angiogenesis and molecular targets for therapy. Front. Biosci. 2009, 14:3962-3973.
9. Cao Y. Angiogenesis: what can it offer for future medicine?. Exp. Cell Res. 2010, 316:1304-1308.
10. Khawaja F.J., Kullo I.J. Novel markers of peripheral arterial disease. Vasc. Med. 2009, 14:381-392.
11. Swain M.G., Appleyard C.B., Wallace J.L., Maric M. TNF-alpha facilitates inflammation-induced glucocorticoid secretion in rats with biliary obstruction. J.Hepatol. 1997, 26:361-368.
12. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev. Immunol. 2001, 19:683-765.
13. Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci. Signal 2009, 2. re1.
14. Crystal R.G. Transfer of genes to humans: early lessons and obstacles to success. Science 1995, 270:404-410.
15. Shimamura M., Nakagami H., Taniyama Y., Morishita R. Gene therapy for peripheral arterial disease. Expert Opin. Biol. Ther. 2014, 14:1175-1184.
16. Felgner P.L., Gadek T.R., Holm M., Roman R., Chan H.W., Wenz M., et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. U. S. A. 1987, 84:7413-7417.
17. Lee H., Jeong J.H., Park T.G. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J.Control Release 2002, 79:283-291.
18. Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 2003, 4:346-358.
19. Dash B.C., Mahor S., Carroll O., Mathew A., Wang W., Woodhouse K.A., et al. Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot. J.Control Release 2011, 152:382-392.
20. Kim W., Chaikof E.L. Recombinant elastin-mimetic biomaterials: emerging applications in medicine. Adv. Drug Deliv. Rev. 2010, 62:1468-1478.
21. Nettles D.L., Chilkoti A., Setton L.A. Applications of elastin-like polypeptides in tissue engineering. Adv. Drug Deliv. Rev. 2010, 62:1479-1485.
22. Brechot N., Gomez E., Bignon M., Khallou-Laschet J., Dussiot M., Cazes A., et al. Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice. PLoS One 2008, 3:e3950.
23. Dai Q., Thompson M.A., Pippen A.M., Cherwek H., Taylor D.A., Annex B.H. Alterations in endothelial cell proliferation and apoptosis contribute to vascular remodeling following hind-limb ischemia in rabbits. Vasc. Med. 2002, 7:87-91.
24. Dash B.C., Rethore G., Monaghan M., Fitzgerald K., Gallagher W., Pandit A. The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility. Biomaterials 2010, 31:8188-8197.
25. Champion J.A., Walker A., Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres. Pharm. Res. 2008, 25:1815-1821.
26. Zhu Y., Tramper J. Novel applications for microbial transglutaminase beyond food processing. Trends Biotechnol. 2008, 26:559-565.
27. Dinerman J.L., Mehta J.L., Saldeen T.G., Emerson S., Wallin R., Davda R., et al. Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction. J.Am. Coll. Cardiol. 1990, 15:1559-1563.
28. Silvestre J.S., Mallat Z., Duriez M., Tamarat R., Bureau M.F., Scherman D., et al. Antiangiogenic effect of interleukin-10 in ischemia-induced angiogenesis in mice hindlimb. Circ. Res. 2000, 87:448-452.
29. Brito L.A., Chandrasekhar S., Little S.R., Amiji M.M. Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis. Biomed. Eng. Online 2010, 9:56.
30. Montes de Oca M., Torres S.H., De Sanctis J., Mata A., Hernandez N., Talamo C. Skeletal muscle inflammation and nitric oxide in patients with COPD. Eur. Respir. J. 2005, 26:390-397.
31. Holladay C., Power K., Sefton M., O'Brien T., Gallagher W.M., Pandit A. Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells invivo. Mol. Ther. 2011, 19:969-978.
32. O'Connor D.M., O'Brien T. Nitric oxide synthase gene therapy: progress and prospects. Expert Opin. Biol. Ther. 2009, 9:867-878.
33. Ren J.G., Jie C., Talbot C. How PEDF prevents angiogenesis: a hypothesized pathway. Med. Hypotheses 2005, 64:74-78.
34. Battegay E.J., Rupp J., Iruela-Arispe L., Sage E.H., Pech M. PDGF-BB modulates endothelial proliferation and angiogenesis invitro via PDGF beta-receptors. J.Cell Biol. 1994, 125:917-928.
35. Hellberg C., Ostman A., Heldin C.H. PDGF and vessel maturation. Recent Results Cancer Res. 2010, 180:103-114.
36. van Hal P.T., Hopstaken-Broos J.P., Prins A., Favaloro E.J., Huijbens R.J., Hilvering C., et al. Potential indirect anti-inflammatory effects of IL-4. Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13; EC 3.4.11.2). J.Immunol. 1994, 153:2718-2728.
37. Woodward E.A., Kolesnik T.B., Nicholson S.E., Prele C.M., Hart P.H. The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2. Cytokine 2012, 58:415-423.
38. Mentlein R., Held-Feindt J. Angiogenesis factors in gliomas: a new key to tumour therapy?. Die Naturwiss. 2003, 90:385-394.
39. Nyberg P., Xie L., Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 2005, 65:3967-3979.
40. Ribatti D. Endogenous inhibitors of angiogenesis: a historical review. Leuk. Res. 2009, 33:638-644.
41. Bellingham C.M., Woodhouse K.A., Robson P., Rothstein S.J., Keeley F.W. Self-aggregation characteristics of recombinantly expressed human elastin polypeptides. Biochim. Biophys. Acta 2001, 1550:6-19.
42. Rethore G., Mathew A., Naik H., Pandit A. Preparation of chitosan/polyglutamic acid spheres based on the use of polystyrene template as a nonviral gene carrier. Tissue Eng. Part C Methods 2009, 15:605-613.
43. Rethore G., Pandit A. Use of templates to fabricate nanoscale spherical structures for defined architectural control. Small 2010, 6:488-498.
44. Bubnis W.A., Ofner C.M. The determination of epsilon-amino groups in soluble and poorly soluble proteinaceous materials by a spectrophotometric method using trinitrobenzenesulfonic acid. Anal. Biochem. 1992, 207:129-133.
45. Peng X., Wang J., Lassance-Soares R.M., Najafi A.H., Sood S., Aghili N., et al. Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia. Am. J. Physiol. Heart Circ. Physiol. 2011, 300:H2027-H2034.
46. Shireman P.K., Quinones M.P. Differential necrosis despite similar perfusion in mouse strains after ischemia. J.Surg. Res. 2005, 129:242-250.
47. Garcia Y., Breen A., Burugapalli K., Dockery P., Pandit A. Stereological methods to assess tissue response for tissue-engineered scaffolds. Biomaterials 2007, 28:175-186.