Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 6, 2011, Pages

  Peng, Xinzhi ^a,b   Wang, Jinsong ^a,b   Lassance Soares, Roberta M ^a   Najafi, Amir H ^a   Sood, Subeena ^a   Aghili, Nima ^a   Alderman, Lee O ^a   Panza, Julio A ^a,c   Faber, James E ^d   Wang, Shenming ^b   Epstein, Stephen E ^a   Burnett, Mary Susan ^a  

^a MEDSTAR RESEARCH INSTITUTE   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c WASHINGTON HOSPITAL CENTER   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Angiogenesis; Arteriogenesis; Vasoreactivity

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MATRIGEL; NITROPRUSSIDE SODIUM; PAPAVERINE; PHOSPHOPROTEIN; VASCULOTROPIN; VASOCONSTRICTOR AGENT;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD FLOW RECOVERY; BLOOD VESSEL REACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HINDLIMB ISCHEMIA; LIGATION; LIMB ISCHEMIA; MALE; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION; WESTERN BLOTTING;

ANIMALS; FEMALE; FEMORAL ARTERY; HINDLIMB; ISCHEMIA; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; REGIONAL BLOOD FLOW; SEX CHARACTERISTICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR RESISTANCE;

EID: 79958021507     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00004.2011     Document Type: Article

References (23)

1. Baumbach GL, Sigmund CD, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circ Res 95: 822-829, 2004.
2. Brevetti G, Bucur R, Balbarini A, Melillo E, Novo S, Muratori I, Chiariello M. Women and peripheral arterial disease: same disease, different issues. J Cardiovasc Med (Hagerstown) 9: 382-388, 2008.
3. Chalothorn D, Clayton JA, Zhang H, Pomp D, Faber JE. Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains. Physiol Genomics 30: 179-191, 2007.
4. Dai X, Faber JE. Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis. Circ Res 106: 1870-1881.
5. Fiebach NH, Viscoli CM, Horwitz RI. Differences between women and men in survival after myocardial infarction. Biology or methodology? JAMA 263: 1092-1096, 1990.
6. Gonzales RJ, Bryant JM, Naik JS, Resta TC, Walker BR. Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia. Microcirculation 15: 473-484, 2008.
7. Greenland P, Reicher-Reiss H, Goldbourt U, Behar S. In-hospital and 1-year mortality in 1,524 women after myocardial infarction. Comparison with 4,315 men. Circulation 83: 484-491, 1991.
8. Hooi JD, Kester AD, Stoffers HE, Overdijk MM, van Ree JW, Knottnerus JA. Incidence of and risk factors for asymptomatic peripheral arterial occlusive disease: a longitudinal study. Am J Epidemiol 153: 666-672, 2001.
9. Huxley VH, Wang J, Whitt SP. Sexual dimorphism in the permeability response of coronary microvessels to adenosine. Am J Physiol Heart Circ Physiol 288: H2006-H2013, 2005.
10. Karakelides H, Irving BA, Short KR, O'Brien P, Nair KS. Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes 59: 89-97, 2010.
11. Kyriakides ZS, Petinakis P, Kaklamanis L, Lyras T, Sbarouni E, Karayannakos P, Iliopoulos D, Kremastinos DT. Gender does not influence angiogenesis and arteriogenesis in a rabbit model of chronic hind limb ischemia. Int J Cardiol 92: 83-91, 2003.
12. Mac Gabhann F, Peirce SM. Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle. Microcirculation 17: 333-347, 2010.
13. Muller-Delp J, Spier SA, Ramsey MW, Lesniewski LA, Papadopoulos A, Humphrey JD, Delp MD. Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles. Am J Physiol Heart Circ Physiol 282: H1843-H1854, 2002.
14. Nguyen LL, Hevelone N, Rogers SO, Bandyk DF, Clowes AW, Moneta GL, Lipsitz S, Conte MS. Disparity in outcomes of surgical revascularization for limb salvage: race and gender are synergistic determinants of vein graft failure and limb loss. Circulation 119: 123-130, 2009.
15. Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, Walter U, Skatchkov M, Meinertz T, Munzel T. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res 87: 999-1005, 2000.
16. Passmore JC, Joshua IG, Rowell PP, Tyagi SC, Falcone JC. Reduced alpha adrenergic mediated contraction of renal preglomerular blood vessels as a function of gender and aging. J Cell Biochem 96: 672-681, 2005.
17. Schaper W, Scholz D. Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol 23: 1143-1151, 2003.
18. Sieveking DP, Lim P, Chow RW, Dunn LL, Bao S, McGrath KC, Heather AK, Handelsman DJ, Celermajer DS, Ng MK. A sex-specific role for androgens in angiogenesis. J Exp Med 207: 345-352.
19. Sigvant B, Wiberg-Hedman K, Bergqvist D, Rolandsson O, Andersson B, Persson E, Wahlberg E. A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences. J Vasc Surg 45: 1185-1191, 2007.
20. Tofler GH, Stone PH, Muller JE, Willich SN, Davis VG, Poole WK, Strauss HW, Willerson JT, Jaffe AS, Robertson T, Passamani ER, Braunwald E, for the MILIS Study Group. Effects of gender and race on prognosis after myocardial infarction: adverse prognosis for women, particularly black women. J Am Coll Cardiol 9: 473-482, 1987.
21. Versteilen AM, Korstjens IJ, Musters RJ, Groeneveld AB, Sipkema P. Rho kinase regulates renal blood flow by modulating eNOS activity in ischemia-reperfusion of the rat kidney. Am J Physiol Renal Physiol 291: F606-F611, 2006.
22. Zbinden S, Wang J, Adenika R, Schmidt M, Tilan JU, Najafi AH, Peng X, Lassance-Soares RM, Iantorno M, Morsli H, Gercenshtein L, Jang GJ, Epstein SE, Burnett MS. Metallothionein enhances angiogenesis and arteriogenesis by modulating smooth muscle cell and macrophage function. Arterioscler Thromb Vasc Biol 30: 477-482.
23. Zhang H, Prabhakar P, Sealock R, Faber JE. Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke. J Cereb Blood Flow Metab 30: 923-934, 2010.