Heavy metal ion regulation of gene expression: Mechanisms by which lead inhibits osteoblastic bone-forming activity through modulation of the Wnt/β-catenin signaling pathway

Journal of Biological Chemistry

Volumn 290, Issue 29, 2015, Pages 18216-18226

  Beier, Eric E ^a   Sheu, Tzong Jen ^a   Dang, Deborah ^a   Holz, Jonathan D ^a   Ubayawardena, Resika ^a   Babij, Philip ^b   Puzas, J Edward ^a,c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b AMGEN INC   (United States)

^c The Center for Musculoskeletal Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES; HEALTH RISKS; HEAVY METALS; MAMMALS; METAL IONS; METALS; MODULATION; SIGNALING;

BONE FORMATION; BONE MARROW CELLS; CATENIN SIGNALING; PEAK BONE MASS; PHARMACOLOGICAL INHIBITORS; SIGNALING PATHWAYS; TRABECULAR BONES; WNT SIGNALING;

LEAD;

BETA CATENIN; HEAVY METAL; LEAD; METAL ION; SCLEROSTIN; WNT PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; GLYCOPROTEIN; POLLUTANT; SMAD3 PROTEIN; SOST PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MASS; BONE STRENGTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SOST GENE; ADVERSE EFFECTS; ANATOMY AND HISTOLOGY; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE; BONE DEVELOPMENT; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; OSTEOBLAST; POLLUTANT; TOXICITY; WNT SIGNALING PATHWAY;

MUS;

ANIMALS; BETA CATENIN; BONE AND BONES; CELL LINE; CELLS, CULTURED; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; GLYCOPROTEINS; LEAD; MALE; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOGENESIS; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT SIGNALING PATHWAY;

EID: 84937408385     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.629204     Document Type: Article

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