Lead (Pb+2) impairs long-term memory and blocks learning-induced increases in hippocampal protein kinase C activity

Toxicology and Applied Pharmacology

Volumn 200, Issue 1, 2004, Pages 27-39

  Vázquez, Adrinel ^a   Peña De Ortiz, Sandra ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Heavy metals; Hippocampus; Holeboard task; Lead neurotoxicity; Long term memory; Protein kinase C; Spatial learning

Indexed keywords

CALCIUM ION; LEAD; LEAD ACETATE; PHOSPHOLIPID; PROTEIN KINASE C; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN REGION; CALCIUM SIGNALING; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL TEST; HIPPOCAMPUS; INFUSION; LATENT PERIOD; LEARNING; LEARNING DISORDER; LONG TERM MEMORY; MALE; MEASUREMENT; MEMORY DISORDER; MENTAL TASK; NERVE CELL; NEUROTOXICITY; NONHUMAN; RAT; TASK PERFORMANCE; TRAINING;

ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD DEPRIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HABITUATION, PSYCHOPHYSIOLOGIC; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEAD; LEARNING; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; PROTEIN KINASE C; RATS; RATS, LONG-EVANS;

EID: 4644350899     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2004.03.011     Document Type: Article

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