메뉴 건너뛰기




Volumn 123, Issue 8, 2015, Pages 639-647

Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma

Author keywords

4E BP1; Esophageal carcinoma; Immunohistochemistry; Molecular analysis; P70S6K; PI3K AKT mTOR pathway

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; EIF4EBP1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; PIK3CA PROTEIN, HUMAN; S6 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84937253598     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12398     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 84880324655 scopus 로고    scopus 로고
    • Lapatinib, a dual inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2, potentiates the antitumor effects of cisplatin on esophageal carcinoma
    • Guo XF, Zhu XF, Zhong GS, Deng BG. Lapatinib, a dual inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2, potentiates the antitumor effects of cisplatin on esophageal carcinoma. Dis Esophagus 2013;26:487-95.
    • (2013) Dis Esophagus , vol.26 , pp. 487-495
    • Guo, X.F.1    Zhu, X.F.2    Zhong, G.S.3    Deng, B.G.4
  • 2
    • 84899628626 scopus 로고    scopus 로고
    • Genomic and molecular characterization of esophageal squamous cell carcinoma
    • Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet 2014;46:467-73.
    • (2014) Nat Genet , vol.46 , pp. 467-473
    • Lin, D.C.1    Hao, J.J.2    Nagata, Y.3    Xu, L.4    Shang, L.5    Meng, X.6
  • 3
    • 84877244768 scopus 로고    scopus 로고
    • Targeting the PI3K-AKT-mTOR signaling network in cancer
    • Khan KH, Yap TA, Yan L, Cunningham D. Targeting the PI3K-AKT-mTOR signaling network in cancer. Chin J Cancer 2013;32:253-65.
    • (2013) Chin J Cancer , vol.32 , pp. 253-265
    • Khan, K.H.1    Yap, T.A.2    Yan, L.3    Cunningham, D.4
  • 4
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • Samuels Y, Ericson K. Oncogenic PI3K and its role in cancer. Curr Opin Oncol 2006;18:77-82.
    • (2006) Curr Opin Oncol , vol.18 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 6
    • 84873243317 scopus 로고    scopus 로고
    • A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma
    • Korkolopoulou P, Levidou G, Trigka EA, Prekete N, Karlou M, Thymara I, et al. A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma. BJU Int 2012;110:E1237-48.
    • (2012) BJU Int , vol.110 , pp. E1237-E1248
    • Korkolopoulou, P.1    Levidou, G.2    Trigka, E.A.3    Prekete, N.4    Karlou, M.5    Thymara, I.6
  • 7
    • 84879636044 scopus 로고    scopus 로고
    • A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features
    • Trigka EA, Levidou G, Saetta AA, Chatziandreou I, Tomos P, Thalassinos N, et al. A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features. Oncol Rep 2013;30:623-36.
    • (2013) Oncol Rep , vol.30 , pp. 623-636
    • Trigka, E.A.1    Levidou, G.2    Saetta, A.A.3    Chatziandreou, I.4    Tomos, P.5    Thalassinos, N.6
  • 8
    • 66349098309 scopus 로고    scopus 로고
    • Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
    • Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, et al. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res 2009;69:4885-93.
    • (2009) Cancer Res , vol.69 , pp. 4885-4893
    • Ricarte-Filho, J.C.1    Ryder, M.2    Chitale, D.A.3    Rivera, M.4    Heguy, A.5    Ladanyi, M.6
  • 9
    • 84874372046 scopus 로고    scopus 로고
    • Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO
    • Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 2013;339:1077-80.
    • (2013) Science , vol.339 , pp. 1077-1080
    • Clark, V.E.1    Erson-Omay, E.Z.2    Serin, A.3    Yin, J.4    Cotney, J.5    Ozduman, K.6
  • 10
    • 84919331288 scopus 로고    scopus 로고
    • Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development
    • El-Habr EA, Levidou G, Trigka EA, Sakalidou J, Piperi C, Chatziandreou I, et al. Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development. Virchows Arch 2014;465:473-85.
    • (2014) Virchows Arch , vol.465 , pp. 473-485
    • El-Habr, E.A.1    Levidou, G.2    Trigka, E.A.3    Sakalidou, J.4    Piperi, C.5    Chatziandreou, I.6
  • 11
    • 79959673065 scopus 로고    scopus 로고
    • Targeting key signalling pathways in oesophageal adenocarcinoma: a reality for personalized medicine?
    • Keld RR, Ang YS. Targeting key signalling pathways in oesophageal adenocarcinoma: a reality for personalized medicine? World J Gastroenterol 2011;17:2781-90.
    • (2011) World J Gastroenterol , vol.17 , pp. 2781-2790
    • Keld, R.R.1    Ang, Y.S.2
  • 15
    • 84877091712 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma
    • Shigaki H, Baba Y, Watanabe M, Murata A, Ishimoto T, Iwatsuki M, et al. PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma. Clin Cancer Res 2013;19:2451-9.
    • (2013) Clin Cancer Res , vol.19 , pp. 2451-2459
    • Shigaki, H.1    Baba, Y.2    Watanabe, M.3    Murata, A.4    Ishimoto, T.5    Iwatsuki, M.6
  • 16
    • 79961123374 scopus 로고    scopus 로고
    • Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer
    • Wei L, Xu Z. Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer. Int J Cancer 2011;129:275-84.
    • (2011) Int J Cancer , vol.129 , pp. 275-284
    • Wei, L.1    Xu, Z.2
  • 17
    • 77956343833 scopus 로고    scopus 로고
    • Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma
    • Hirashima K, Baba Y, Watanabe M, Karashima R, Sato N, Imamura Y, et al. Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma. Ann Surg Oncol 2010;17:2486-93.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2486-2493
    • Hirashima, K.1    Baba, Y.2    Watanabe, M.3    Karashima, R.4    Sato, N.5    Imamura, Y.6
  • 18
    • 47549086553 scopus 로고    scopus 로고
    • The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis
    • Yoshioka A, Miyata H, Doki Y, Yasuda T, Yamasaki M, Motoori M, et al. The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis. Oncol Rep 2008;19:1099-107.
    • (2008) Oncol Rep , vol.19 , pp. 1099-1107
    • Yoshioka, A.1    Miyata, H.2    Doki, Y.3    Yasuda, T.4    Yamasaki, M.5    Motoori, M.6
  • 19
    • 33646089881 scopus 로고    scopus 로고
    • Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer
    • Salehi Z, Mashayekhi F. Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer. Clin Biochem 2006;39:404-9.
    • (2006) Clin Biochem , vol.39 , pp. 404-409
    • Salehi, Z.1    Mashayekhi, F.2
  • 21
    • 40149101093 scopus 로고    scopus 로고
    • PIK3CA mutation status in Japanese esophageal squamous cell carcinoma
    • Mori R, Ishiguro H, Kimura M, Mitsui A, Sasaki H, Tomoda K, et al. PIK3CA mutation status in Japanese esophageal squamous cell carcinoma. J Surg Res 2008;145:320-6.
    • (2008) J Surg Res , vol.145 , pp. 320-326
    • Mori, R.1    Ishiguro, H.2    Kimura, M.3    Mitsui, A.4    Sasaki, H.5    Tomoda, K.6
  • 22
    • 84864554415 scopus 로고    scopus 로고
    • High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations
    • Maeng CH, Lee J, van Hummelen P, Park SH, Palescandolo E, Jang J, et al. High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations. PLoS One 2012;7:e41655.
    • (2012) PLoS One , vol.7 , pp. e41655
    • Maeng, C.H.1    Lee, J.2    van Hummelen, P.3    Park, S.H.4    Palescandolo, E.5    Jang, J.6
  • 23
    • 84892783833 scopus 로고    scopus 로고
    • Frequency, characterization, and prognostic analysis of PIK3CA gene mutations in Chinese esophageal squamous cell carcinoma
    • Hou J, Jiang D, Zhang J, Gavine PR, Xu S, Liu Y, et al. Frequency, characterization, and prognostic analysis of PIK3CA gene mutations in Chinese esophageal squamous cell carcinoma. Hum Pathol 2014;45:352-8.
    • (2014) Hum Pathol , vol.45 , pp. 352-358
    • Hou, J.1    Jiang, D.2    Zhang, J.3    Gavine, P.R.4    Xu, S.5    Liu, Y.6
  • 24
    • 64549158092 scopus 로고    scopus 로고
    • Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma
    • Akagi I, Miyashita M, Makino H, Nomura T, Hagiwara N, Takahashi K, et al. Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Int J Oncol 2009;34:767-75.
    • (2009) Int J Oncol , vol.34 , pp. 767-775
    • Akagi, I.1    Miyashita, M.2    Makino, H.3    Nomura, T.4    Hagiwara, N.5    Takahashi, K.6
  • 25
    • 70350047166 scopus 로고    scopus 로고
    • Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas
    • Eom HS, Kim MS, Hur SY, Yoo NJ, Lee SH. Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas. Acta Oncol 2009;48:1084-5.
    • (2009) Acta Oncol , vol.48 , pp. 1084-1085
    • Eom, H.S.1    Kim, M.S.2    Hur, S.Y.3    Yoo, N.J.4    Lee, S.H.5
  • 26
    • 84867398217 scopus 로고    scopus 로고
    • Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    • Agrawal N, Jiao Y, Bettegowda C, Hutfless SM, Wang Y, David S, et al. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov 2012;2:899-905.
    • (2012) Cancer Discov , vol.2 , pp. 899-905
    • Agrawal, N.1    Jiao, Y.2    Bettegowda, C.3    Hutfless, S.M.4    Wang, Y.5    David, S.6
  • 27
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang GG, Abraham RT. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 2005;280:25485-90.
    • (2005) J Biol Chem , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 28
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-8.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6
  • 29
  • 30
    • 79951529849 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
    • Chong ZZ, Shang YC, Zhang L, Wang S, Maiese K. Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev 2010;3:374-91.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 374-391
    • Chong, Z.Z.1    Shang, Y.C.2    Zhang, L.3    Wang, S.4    Maiese, K.5
  • 31
    • 33745260930 scopus 로고    scopus 로고
    • AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signalling
    • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signalling. Cancer Res 2006;66:5618-23.
    • (2006) Cancer Res , vol.66 , pp. 5618-5623
    • Riemenschneider, M.J.1    Betensky, R.A.2    Pasedag, S.M.3    Louis, D.N.4
  • 33
    • 77954296394 scopus 로고    scopus 로고
    • 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
    • She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, et al. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell 2010;18:39-51.
    • (2010) Cancer Cell , vol.18 , pp. 39-51
    • She, Q.B.1    Halilovic, E.2    Ye, Q.3    Zhen, W.4    Shirasawa, S.5    Sasazuki, T.6
  • 34
    • 84155175868 scopus 로고    scopus 로고
    • ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma
    • Cohen JD, Gard JM, Nagle RB, Dietrich JD, Monks TJ, Lau SS. ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. Toxicol Sci 2011;124:75-87.
    • (2011) Toxicol Sci , vol.124 , pp. 75-87
    • Cohen, J.D.1    Gard, J.M.2    Nagle, R.B.3    Dietrich, J.D.4    Monks, T.J.5    Lau, S.S.6
  • 35
  • 36
    • 85027927262 scopus 로고    scopus 로고
    • Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas
    • Li XY, Zhang LQ, Zhang XG, Li X, Ren YB, Ma XY, et al. Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas. J Neurooncol 2011;103:453-8.
    • (2011) J Neurooncol , vol.103 , pp. 453-458
    • Li, X.Y.1    Zhang, L.Q.2    Zhang, X.G.3    Li, X.4    Ren, Y.B.5    Ma, X.Y.6
  • 38
    • 79959758262 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder
    • Sun CH, Chang YH, Pan CC. Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology 2011;58:1054-63.
    • (2011) Histopathology , vol.58 , pp. 1054-1063
    • Sun, C.H.1    Chang, Y.H.2    Pan, C.C.3
  • 39
    • 78649556380 scopus 로고    scopus 로고
    • Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
    • Schultz L, Albadine R, Hicks J, Jadallah S, DeMarzo AM, Chen YB, et al. Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy. Cancer 2010;116:5517-26.
    • (2010) Cancer , vol.116 , pp. 5517-5526
    • Schultz, L.1    Albadine, R.2    Hicks, J.3    Jadallah, S.4    DeMarzo, A.M.5    Chen, Y.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.