-
1
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Y. Samuels, Z. Wang, and A. Bardelli et al. High frequency of mutations of the PIK3CA gene in human cancers Science 304 2004 554
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
2
-
-
13944284494
-
Oncogenic mutations of PIK3CA in human cancers
-
Y. Samuels, and V.E. Velculescu Oncogenic mutations of PIK3CA in human cancers Cell Cycle 3 2004 1221 1224
-
(2004)
Cell Cycle
, vol.3
, pp. 1221-1224
-
-
Samuels, Y.1
Velculescu, V.E.2
-
3
-
-
33646706052
-
Oncogenic PI3K and its role in cancer
-
Y. Samuels, and K. Ericson Oncogenic PI3K and its role in cancer Curr Opin Oncol 18 2006 77 82
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 77-82
-
-
Samuels, Y.1
Ericson, K.2
-
4
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Y. Samuels, and L.A. Diaz Jr. et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells Cancer Cell 7 2005 561 573
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
-
5
-
-
79952108510
-
Oncogenic mutations of PIK3CA in human cancers
-
Y. Samuels, and T. Waldman Oncogenic mutations of PIK3CA in human cancers Curr Top Microbiol Immunol 347 2010 21 41
-
(2010)
Curr Top Microbiol Immunol
, vol.347
, pp. 21-41
-
-
Samuels, Y.1
Waldman, T.2
-
6
-
-
51849128358
-
Class I PI3K in oncogenic cellular transformation
-
L. Zhao, and P.K. Vogt Class I PI3K in oncogenic cellular transformation Oncogene 27 2008 5486 5496
-
(2008)
Oncogene
, vol.27
, pp. 5486-5496
-
-
Zhao, L.1
Vogt, P.K.2
-
7
-
-
84859865072
-
Prognostic role of PIK3CA mutation in colorectal cancer: Cohort study and literature review
-
X. Liao, T. Morikawa, and P. Lochhead et al. Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review Clin Cancer Res 18 2012 2257 2268
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2257-2268
-
-
Liao, X.1
Morikawa, T.2
Lochhead, P.3
-
8
-
-
79959733118
-
Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer
-
E. Razis, M. Bobos, and V. Kotoula et al. Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer Breast Cancer Res Treat 128 2011 447 456
-
(2011)
Breast Cancer Res Treat
, vol.128
, pp. 447-456
-
-
Razis, E.1
Bobos, M.2
Kotoula, V.3
-
9
-
-
80054690349
-
PIK3CA mutations and amplification in endometrioid endometrial carcinomas: Relation to other genetic defects and clinicopathologic status of the tumors
-
B. Konopka, A. Janiec-Jankowska, and E. Kwiatkowska et al. PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors Hum Pathol 42 2011 1710 1719
-
(2011)
Hum Pathol
, vol.42
, pp. 1710-1719
-
-
Konopka, B.1
Janiec-Jankowska, A.2
Kwiatkowska, E.3
-
10
-
-
83355163329
-
Gdc-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
-
J.J. Wallin, K.A. Edgar, and J. Guan et al. Gdc-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway Mol Cancer Ther 10 2011 2426 2436
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2426-2436
-
-
Wallin, J.J.1
Edgar, K.A.2
Guan, J.3
-
11
-
-
0033856462
-
PI3-kinase inhibition: A target for drug development?
-
R.C. Stein, and M.D. Waterfield PI3-kinase inhibition: a target for drug development? Mol Med Today 6 2000 347 357
-
(2000)
Mol Med Today
, vol.6
, pp. 347-357
-
-
Stein, R.C.1
Waterfield, M.D.2
-
12
-
-
81055149891
-
Pf-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity
-
J. Yuan, P.P. Mehta, and M.J. Yin et al. Pf-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity Mol Cancer Ther 10 2011 2189 2199
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2189-2199
-
-
Yuan, J.1
Mehta, P.P.2
Yin, M.J.3
-
13
-
-
76049123027
-
Specific apoptosis induction by the dual PI3K/mTOR inhibitor nvp-bez235 in HER2 amplified and PIK3CA mutant breast cancer cells
-
S.M. Brachmann, I. Hofmann, and C. Schnell et al. Specific apoptosis induction by the dual PI3K/mTOR inhibitor nvp-bez235 in HER2 amplified and PIK3CA mutant breast cancer cells Proc Natl Acad Sci U S A 106 2009 22299 22304
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 22299-22304
-
-
Brachmann, S.M.1
Hofmann, I.2
Schnell, C.3
-
14
-
-
80053643924
-
Squamous cell carcinoma of the oesophagus
-
F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise, 4th ed. IARC Press Lyon
-
E. Montgomery, J.K. Field, P. Boffetta, Y. Daigo, M. Shimizu, and T. Shimoda Squamous cell carcinoma of the oesophagus F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise, WHO Classification of Tumours of the Digestive System 4th ed. 2010 IARC Press Lyon 18 24
-
(2010)
WHO Classification of Tumours of the Digestive System
, pp. 18-24
-
-
Montgomery, E.1
Field, J.K.2
Boffetta, P.3
Daigo, Y.4
Shimizu, M.5
Shimoda, T.6
-
16
-
-
33646395120
-
Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus
-
W.A. Phillips, S.E. Russell, and M.L. Ciavarella et al. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus Int J Cancer 118 2006 2644 2646
-
(2006)
Int J Cancer
, vol.118
, pp. 2644-2646
-
-
Phillips, W.A.1
Russell, S.E.2
Ciavarella, M.L.3
-
17
-
-
40149101093
-
PIK3CA mutation status in Japanese esophageal squamous cell carcinoma
-
R. Mori, H. Ishiguro, and M. Kimura et al. PIK3CA mutation status in Japanese esophageal squamous cell carcinoma J Surg Res 145 2008 320 326
-
(2008)
J Surg Res
, vol.145
, pp. 320-326
-
-
Mori, R.1
Ishiguro, H.2
Kimura, M.3
-
18
-
-
64549158092
-
Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma
-
I. Akagi, M. Miyashita, and H. Makino et al. Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma Int J Oncol 34 2009 767 775
-
(2009)
Int J Oncol
, vol.34
, pp. 767-775
-
-
Akagi, I.1
Miyashita, M.2
Makino, H.3
-
19
-
-
84877091712
-
PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma
-
H. Shigaki, Y. Baba, and M. Watanabe et al. PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma Clin Cancer Res 19 2013 2451 2459
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2451-2459
-
-
Shigaki, H.1
Baba, Y.2
Watanabe, M.3
-
20
-
-
79955025404
-
Multidisciplinary management of early and locally advanced esophageal cancer
-
J.T. Kaifi, N.J. Gusani, and Y. Jiang et al. Multidisciplinary management of early and locally advanced esophageal cancer J Clin Gastroenterol 45 2011 391 399
-
(2011)
J Clin Gastroenterol
, vol.45
, pp. 391-399
-
-
Kaifi, J.T.1
Gusani, N.J.2
Jiang, Y.3
-
21
-
-
77955439879
-
A novel mutant-enriched liquid chip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples
-
S. Wu, Z. Zhu, J. He, X. Luo, J. Xu, and L. Ren-Heidenreich A novel mutant-enriched liquid chip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples Clin Chem Lab Med 48 2010 1103 1106
-
(2010)
Clin Chem Lab Med
, vol.48
, pp. 1103-1106
-
-
Wu, S.1
Zhu, Z.2
He, J.3
Luo, X.4
Xu, J.5
Ren-Heidenreich, L.6
-
22
-
-
38949133202
-
PIK3CA cancer mutations display gender and tissue specificity patterns
-
S. Benvenuti, M. Frattini, and S. Arena et al. PIK3CA cancer mutations display gender and tissue specificity patterns Hum Mutat 29 2008 284 288
-
(2008)
Hum Mutat
, vol.29
, pp. 284-288
-
-
Benvenuti, S.1
Frattini, M.2
Arena, S.3
-
23
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
K.E. Bachman, P. Argani, and Y. Samuels et al. The PIK3CA gene is mutated with high frequency in human breast cancers Cancer Biol Ther 3 2004 772 775
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
-
24
-
-
20044388328
-
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
-
J.W. Lee, Y.H. Soung, and S.Y. Kim et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas Oncogene 24 2005 1477 1480
-
(2005)
Oncogene
, vol.24
, pp. 1477-1480
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
-
25
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and Erbb2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
L.H. Saal, K. Holm, and M. Maurer et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and Erbb2, and are mutually exclusive with PTEN loss in human breast carcinoma Cancer Res 65 2005 2554 2559
-
(2005)
Cancer Res
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
-
26
-
-
3442878125
-
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
-
D.K. Broderick, C. Di, and T.J. Parrett et al. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas Cancer Res 64 2004 5048 5050
-
(2004)
Cancer Res
, vol.64
, pp. 5048-5050
-
-
Broderick, D.K.1
Di, C.2
Parrett, T.J.3
-
27
-
-
77953422867
-
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
-
S. Loi, B. Haibe-Kains, and S. Majjaj et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer Proc Natl Acad Sci U S A 107 2009 10208 10213
-
(2009)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10208-10213
-
-
Loi, S.1
Haibe-Kains, B.2
Majjaj, S.3
-
28
-
-
84872682452
-
PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma
-
A. Abe, T. Minaguchi, and H. Ochi et al. PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma Hum Pathol 44 2013 199 207
-
(2013)
Hum Pathol
, vol.44
, pp. 199-207
-
-
Abe, A.1
Minaguchi, T.2
Ochi, H.3
-
29
-
-
84878558999
-
The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
-
V. Eklof, M.L. Wikberg, and S. Edin et al. The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer Br J Cancer 108 2013 2153 2163
-
(2013)
Br J Cancer
, vol.108
, pp. 2153-2163
-
-
Eklof, V.1
Wikberg, M.L.2
Edin, S.3
-
30
-
-
84864554415
-
High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations
-
C.H. Maeng, J. Lee, and P. van Hummelen et al. High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations PLoS One 7 2012 e41655
-
(2012)
PLoS One
, vol.7
, pp. 41655
-
-
Maeng, C.H.1
Lee, J.2
Van Hummelen, P.3
|