Stimulation of the Angiotensin II AT2 Receptor is Anti-inflammatory in Human Lipopolysaccharide-Activated Monocytic Cells

Inflammation

Volumn 38, Issue 4, 2015, Pages 1690-1699

  Menk, Mario ^a   Graw, Jan Adriaan ^a   von Haefen, Clarissa ^a   Sifringer, Marco ^a   Schwaiberger, David ^a   Unger, Thomas ^b   Steckelings, Ulrike ^c   Spies, Claudia D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

AT2 receptor; Compound 21 (C21); inflammation; monocytes; THP 1 cells

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RESPONSE; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; U937 CELL LINE; AGONISTS; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOPOLYSACCHARIDES; MONOCYTES; RECEPTOR, ANGIOTENSIN, TYPE 2; U937 CELLS;

EID: 84937252863     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-015-0146-9     Document Type: Article

References (41)

1. Abadir, P.M., J.D. Walston, R.M. Carey, and H.M. Siragy. 2011. Angiotensin II type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production. Journal of Interferon & Cytokine Research 31(6): 471–474.
2. Albiston, A.L., S.G. McDowall, D. Matsacos, P. Sim, E. Clune, T. Mustafa, J. Lee, F.A. Mendelsohn, R.J. Simpson, L.M. Connolly, and S.Y. Chai. 2001. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. The Journal of Biological Chemistry 276(52): 48623–48626.
3. Bader, M., and D. Ganten. 2008. Update on tissue renin-angiotensin systems. Journal of Molecular Medicine (Berlin, Germany) 86(6): 615–621.
4. Cesari, M., G.P. Rossi, and A.C. Pessina. 2002. Biological properties of the angiotensin peptides other than angiotensin II: implications for hypertension and cardiovascular diseases. Journal of Hypertension 20(5): 793–799.
5. Clozel, M., H. Kuhn, F. Hefti, and H.R. Baumgartner. 1991. Endothelial dysfunction and subendothelial monocyte macrophages in hypertension. Effect of angiotensin converting enzyme inhibition. Hypertension 18(2): 132–141.
6. Crowley, S.D., C.W. Frey, S.K. Gould, R. Griffiths, P. Ruiz, J.L. Burchette, D.N. Howell, N. Makhanova, M. Yan, H.S. Kim, P.L. Tharaux, and T.M. Coffman. 2008. Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. American Journal of Physiology. Renal Physiology 295(2): F515–F524.
7. de Gasparo, M., K.J. Catt, T. Inagami, J.W. Wright, and T. Unger. 2000. International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacological Reviews 52(3): 415–472.
8. Dhande, I., Q. Ali, and T. Hussain. 2013. Proximal tubule angiotensin AT2 receptors mediate an anti-inflammatory response via interleukin-10: role in renoprotection in obese rats. Hypertension 61(6): 1218–1226.
9. Dhande, I., W. Ma, and T. Hussain. 2015. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Research: Official Journal of the Japan Society of Hypertension 38(1): 21–29.
10. Gallinat, S., M. Yu, A. Dorst, T. Unger, and T. Herdegen. 1998. Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves. Brain Research. Molecular Brain Research 57(1): 111–122.
11. Haller, H., M. Behrend, J.K. Park, T. Schaberg, F.C. Luft, and A. Distler. 1995. Monocyte infiltration and c-fms expression in hearts of spontaneously hypertensive rats. Hypertension 25(1): 132–138.
12. Johnson, R.J., C.E. Alpers, A. Yoshimura, D. Lombardi, P. Pritzl, J. Floege, and S.M. Schwartz. 1992. Renal injury from angiotensin II-mediated hypertension. Hypertension 19(5): 464–474.
13. Kaschina, E., A. Grzesiak, J. Li, A. Foryst-Ludwig, M. Timm, F. Rompe, M. Sommerfeld, U.R. Kemnitz, C. Curato, P. Namsolleck, C. Tschöpe, A. Hallberg, M. Alterman, T. Hucko, I. Paetsch, T. Dietrich, B. Schnackenburg, K. Graf, B. Dahlöf, U. Kintscher, T. Unger, and U.M. Steckelings. 2008. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118(24): 2523–2532.
14. Kurisu, S., R. Ozono, T. Oshima, M. Kambe, T. Ishida, H. Sugino, H. Matsuura, K. Chayama, Y. Teranishi, O. Iba, K. Amano, and H. Matsubara. 2003. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension 41(1): 99–107.
15. Li, J., J. Culman, H. Hörtnagl, Y. Zhao, N. Gerova, M. Timm, A. Blume, M. Zimmermann, K. Seidel, U. Dirnagl, and T. Unger. 2005. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury. FASEB 19(6): 617–619.
16. Ma, L.J., B.A. Corsa, J. Zhou, H. Yang, H. Li, Y.W. Tang, V.R. Babaev, A.S. Major, M.F. Linton, S. Fazio, T.E. Hunley, V. Kon, and A.B.. Fogo. 2011. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. American Journal of Physiology. Renal Physiology 300(5): F1203–F1213.
17. Marut, W., N. Kavian, A. Servettaz, T. Hua-Huy, C. Nicco, C. Chéreau, B. Weill, A.T. Dinh-Xuan, and F. Batteux. 2013. Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade. Arthritis and Rheumatism 65(5): 1367–1377.
18. Matavelli, L.C., J. Huang, and H.M. Siragy. 2011. Angiotensin AT2 receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension 57(2): 308–313.
19. Menk, M., C. von Haefen, H. Funke-Kaiser, M. Sifringer, J.H. Schefe, S. Kirsch, K. Seidel, J. Reinemund, U.M. Steckelings, T. Unger, and C.D. Spies. 2010. Ethanol-induced downregulation of the angiotensin AT2 receptor in murine fibroblasts is mediated by PARP-1. Alcohol 44(6): 495–506.
20. Min, L.J., M. Mogi, K. Tsukuda, F. Jing, K. Ohshima, H. Nakaoka, H. Kan-No, X.L. Wang, T. Chisaka, H.Y. Bai, J. Iwanami, and M. Horiuchi. 2014. Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage. American Journal of Hypertension 27(8): 1036–1044.
21. Murugaiah, A.M., X. Wu, C. Wallinder, A.K. Mahalingam, Y. Wan, C. Sköld, M. Botros, M.O. Guimond, A. Joshi, F. Nyberg, N. Gallo-Payet, A. Hallberg, and M. Alterman. 2012. From the first selective non-peptide AT(2) receptor agonist to structurally related antagonists. Journal of Medicinal Chemistry 55(5): 2265–2278.
22. Nahmod, K.A., M.E. Vermeulen, S. Raiden, G. Salamone, R. Gamberale, P. Fernández-Calotti, A. Alvarez, V. Nahmod, M. Giordano, and J.R. Geffner. 2003. Control of dendritic cell differentiation by angiotensin II. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 17(3): 491–493.
23. Namsolleck, P., F. Boato, K. Schwengel, L. Paulis, K.S. Matho, N. Geurts, C. Thöne-Reineke, K. Lucht, K. Seidel, A. Hallberg, B. Dahlöf, T. Unger, S. Hendrix, and U.M. Steckelings. 2013. AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiology of Disease 51: 177–191.
24. Okamura, A., H. Rakugi, M. Ohishi, Y. Yanagitani, S. Takiuchi, K. Moriguchi, P.A. Fennessy, J. Higaki, and T. Ogihara. 1999. Upregulation of renin-angiotensin system during differentiation of monocytes to macrophages. Journal of Hypertension 17(4): 537–545.
25. Phillips, M.I., and S. Kagiyama. 2002. Angiotensin II as a pro-inflammatory mediator. Current Opinion in Investigational Drugs 3(4): 569–577.
26. Pueyo, M.E., W. Gonzalez, A. Nicoletti, F. Savoie, J.F. Arnal, and J.B. Michel. 2000. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Arteriosclerosis, Thrombosis, and Vascular Biology 20(3): 645–651.
27. Rafatian, N., R.W. Milne, F.H. Leenen, and S.C. Whitman. 2013. Role of renin-angiotensin system in activation of macrophages by modified lipoproteins. American Journal of Physiology. Heart and Circulatory Physiology 305(9): H1309–H1320.
28. Rehman, A., A. Leibowitz, N. Yamamoto, Y. Rautureau, P. Paradis, and E.L. Schiffrin. 2012. Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 59(2): 291–299.
29. Rompe, F., M. Artuc, A. Hallberg, M. Alterman, K. Ströder, C. Thöne-Reineke, A. Reichenbach, J. Schacherl, B. Dahlöf, M. Bader, N. Alenina, M. Schwaninger, T. Zuberbier, H. Funke-Kaiser, C. Schmidt, W.H. Schunck, T. Unger, and U.M. Steckelings. 2010. Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 55(4): 924–931.
30. Sampson, A.K., Irvine, J.C., Shihata, W.A., Dragoljevic, D., Lumsden, N., Huet, O., Barnes, T., Unger, T., Steckelings, U.M., Jennings, G.L., Widdop, R.E. and J.P. Chin-Dusting. 2015. Compound 21 prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo, British Journal of Pharmacology.
31. Saraiva, M., and A. O’Garra. 2010. The regulation of IL-10 production by immune cells, nature reviews. Immunology 10(3): 170–181.
32. Steckelings, U.M., M. Larhed, A. Hallberg, R.E. Widdop, E.S. Jones, C. Wallinder, P. Namsolleck, B. Dahlöf, and T. Unger. 2011. Non-peptide AT2-receptor agonists. Current Opinion in Pharmacology 11(2): 187–192.
33. Steckelings, U.M., F. Rompe, E. Kaschina, P. Namsolleck, A. Grzesiak, H. Funke-Kaiser, M. Bader, and T. Unger. 2010. The past, present and future of angiotensin II type 2 receptor stimulation. Journal of the Renin-Angiotensin-Aldosterone System: JRAAS 11(1): 67–73.
34. Suzuki, Y., M. Ruiz-Ortega, O. Lorenzo, M. Ruperez, V. Esteban, and J. Egido. 2003. Inflammation and angiotensin II. The International Journal of Biochemistry & Cell Biology 35(6): 881–900.
35. Unger, T., O. Chung, T. Csikos, J. Culman, S. Gallinat, P. Gohlke, S. Höhle, S. Meffert, M. Stoll, U. Stroth, and Y.Z. Zhu. 1996. Angiotensin receptors, Journal of Hypertension. Supplement: Official Journal of the International Society of Hypertension 14(5): S95–S103.
36. Valero-Esquitino, V., K. Lucht, P. Namsolleck, F. Monnet-Tschudi, T. Stubbe, F. Lucht, M. Liu, F. Ebner, C. Brandt, L.A. Danyel, D.C. Villela, L. Paulis, C. Thoene-Reineke, B. Dahlöf, A. Hallberg, T. Unger, C. Sumners, and U.M. Steckelings. 2015. Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice. Clinical Science 128(2): 95–109.
37. Villela, D., J. Leonhardt, N. Patel, J. Joseph, S. Kirsch, A. Hallberg, T. Unger, M. Bader, R.A. Santos, C. Sumners, and U.M. Steckelings. 2015. Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison. Clinical Science 128(4): 227–234.
38. Wan, Y., C. Wallinder, B. Plouffe, H. Beaudry, A.K. Mahalingam, X. Wu, B. Johansson, M. Holm, M. Botoros, A. Karlén, A. Pettersson, F. Nyberg, L. Fändriks, N. Gallo-Payet, A. Hallberg, and M. Alterman. 2004. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. Journal of Medicinal Chemistry 47(24): 5995–6008.
39. Wolf, G., J. Bohlender, T. Bondeva, T. Roger, F. Thaiss, and U.O. Wenzel. 2006. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Journal of the American Society of Nephrology: JASN 17(6): 1585–1593.
40. Yamamoto, S., P.G. Yancey, Y. Zuo, L.J. Ma, R. Kaseda, A.B.. Fogo, I. Ichikawa, M.F. Linton, S. Fazio, and V. Kon. 2011. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 31(12): 2856–2864.
41. Yi, E.T., R.X. Liu, Y. Wen, and C.H. Yin. 2012. Telmisartan attenuates hepatic fibrosis in bile duct-ligated rats. Acta Pharmacologica Sinica 33(12): 1518–1524.