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Volumn 34, Issue 3, 2015, Pages 1388-1396

Evodiamine inhibits the proliferation of human osteosarcoma cells by blocking PI3K/Akt signaling

Author keywords

Evodiamine; Osteosarcoma; Proliferation inhibition; PTEN PI3K Akt

Indexed keywords

AKT 1 PROTEIN; EVODIAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG; QUINAZOLINE DERIVATIVE;

EID: 84937231969     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4084     Document Type: Article
Times cited : (41)

References (51)
  • 1
    • 84907225912 scopus 로고    scopus 로고
    • Effect of combination therapy on joint destruction in rheumatoid arthritis: A network meta-analysis of randomized controlled trials
    • Graudal N, Hubeck-Graudal T, Tarp S, Christensen R and Jurgens G: Effect of combination therapy on joint destruction in rheumatoid arthritis: A network meta-analysis of randomized controlled trials. PLoS One 9: e106408, 2014.
    • (2014) PLoS One , vol.9 , pp. e106408
    • Graudal, N.1    Hubeck-Graudal, T.2    Tarp, S.3    Christensen, R.4    Jurgens, G.5
  • 3
    • 63449118087 scopus 로고    scopus 로고
    • Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program
    • Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program. Cancer 115: 1531-1543, 2009.
    • (2009) Cancer , vol.115 , pp. 1531-1543
    • Mirabello, L.1    Troisi, R.J.2    Savage, S.A.3
  • 4
    • 3543035771 scopus 로고    scopus 로고
    • Biology and therapeutic advances for pediatric osteosarcoma
    • Marina N, Gebhardt M, Teot L and Gorlick R: Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9: 422-441, 2004.
    • (2004) Oncologist , vol.9 , pp. 422-441
    • Marina, N.1    Gebhardt, M.2    Teot, L.3    Gorlick, R.4
  • 5
    • 7344244871 scopus 로고
    • Osteogenic sarcoma; An analysis of the age and sex incidence
    • Price CH: Osteogenic sarcoma; an analysis of the age and sex incidence. Br J Cancer 9: 558-574, 1955.
    • (1955) Br J Cancer , vol.9 , pp. 558-574
    • Price, C.H.1
  • 6
    • 0005443537 scopus 로고
    • Osteogenic sarcoma. A follow-up study of the ninety-four cases observed at the Massachusetts General Hospital from 1920 to 1960
    • Weinfeld MS and Dudley HR Jr: Osteogenic sarcoma. A follow-up study of the ninety-four cases observed at the Massachusetts General Hospital from 1920 to 1960. J Bone Joint Surg Am 44-A: 269-276, 1962.
    • (1962) J Bone Joint Surg Am , vol.44 A , pp. 269-276
    • Weinfeld, M.S.1    Dudley, H.R.2
  • 7
    • 0014044987 scopus 로고
    • Osteogenic sarcoma. A study of six hundred cases
    • Dahlin DC and Coventry MB: Osteogenic sarcoma. A study of six hundred cases. J Bone Joint Surg Am 49: 101-110, 1967.
    • (1967) J Bone Joint Surg Am , vol.49 , pp. 101-110
    • Dahlin, D.C.1    Coventry, M.B.2
  • 9
    • 33745642092 scopus 로고    scopus 로고
    • Novel therapeutic approaches in pediatric and young adult sarcomas
    • Anderson PM and Pearson M: Novel therapeutic approaches in pediatric and young adult sarcomas. Curr Oncol Rep 8: 310-315, 2006.
    • (2006) Curr Oncol Rep , vol.8 , pp. 310-315
    • Anderson, P.M.1    Pearson, M.2
  • 11
    • 0030855524 scopus 로고    scopus 로고
    • Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages
    • Chiou WF, Sung YJ, Liao JF, Shum AY and Chen CF: Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages. J Nat Prod 60: 708-711, 1997.
    • (1997) J Nat Prod , vol.60 , pp. 708-711
    • Chiou, W.F.1    Sung, Y.J.2    Liao, J.F.3    Shum, A.Y.4    Chen, C.F.5
  • 12
    • 0038434288 scopus 로고    scopus 로고
    • The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice
    • Kobayashi Y: The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice. Planta Med 69: 425-428, 2003.
    • (2003) Planta Med , vol.69 , pp. 425-428
    • Kobayashi, Y.1
  • 14
    • 84926393481 scopus 로고    scopus 로고
    • Anti-proliferative effects of evodiamine in human lung cancer cells
    • Hong JY, Park SH, Min HY, Park HJ and Lee SK: Anti-proliferative effects of evodiamine in human lung cancer cells. J Cancer Prev 19: 7-13, 2014.
    • (2014) J Cancer Prev , vol.19 , pp. 7-13
    • Hong, J.Y.1    Park, S.H.2    Min, H.Y.3    Park, H.J.4    Lee, S.K.5
  • 16
    • 10344263866 scopus 로고    scopus 로고
    • Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes
    • Huang YC, Guh JH and Teng CM: Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes. Life Sci 75: 35-49, 2004.
    • (2004) Life Sci , vol.75 , pp. 35-49
    • Huang, Y.C.1    Guh, J.H.2    Teng, C.M.3
  • 17
    • 0037986592 scopus 로고    scopus 로고
    • Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells
    • Fei XF, Wang BX, Li TJ, Tashiro S, Minami M, Xing DJ and Ikejima T: Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells. Cancer Sci 94: 92-98, 2003.
    • (2003) Cancer Sci , vol.94 , pp. 92-98
    • Fei, X.F.1    Wang, B.X.2    Li, T.J.3    Tashiro, S.4    Minami, M.5    Xing, D.J.6    Ikejima, T.7
  • 18
    • 34247498234 scopus 로고    scopus 로고
    • Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3
    • Kan SF, Yu CH, Pu HF, Hsu JM, Chen MJ and Wang PS: Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3. J Cell Biochem 101: 44-56, 2007.
    • (2007) J Cell Biochem , vol.101 , pp. 44-56
    • Kan, S.F.1    Yu, C.H.2    Pu, H.F.3    Hsu, J.M.4    Chen, M.J.5    Wang, P.S.6
  • 19
    • 2942554803 scopus 로고    scopus 로고
    • Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP
    • Kan SF, Huang WJ, Lin LC and Wang PS: Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP. Int J Cancer 110: 641-651, 2004.
    • (2004) Int J Cancer , vol.110 , pp. 641-651
    • Kan, S.F.1    Huang, W.J.2    Lin, L.C.3    Wang, P.S.4
  • 20
    • 10344234253 scopus 로고    scopus 로고
    • Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine
    • Huang DM, Guh JH, Huang YT, Chueh SC, Chiang PC and Teng CM: Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine. J Urol 173: 256-261, 2005.
    • (2005) J Urol , vol.173 , pp. 256-261
    • Huang, D.M.1    Guh, J.H.2    Huang, Y.T.3    Chueh, S.C.4    Chiang, P.C.5    Teng, C.M.6
  • 21
    • 84870364791 scopus 로고    scopus 로고
    • Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
    • Yang J, Cai X, Lu W, Hu C, Xu X, Yu Q and Cao P: Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer Lett 328: 243-251, 2013.
    • (2013) Cancer Lett , vol.328 , pp. 243-251
    • Yang, J.1    Cai, X.2    Lu, W.3    Hu, C.4    Xu, X.5    Yu, Q.6    Cao, P.7
  • 22
    • 84901008792 scopus 로고    scopus 로고
    • Targeting PI3K/Akt/mTOR signaling in cancer
    • Porta C, Paglino C and Mosca A: Targeting PI3K/Akt/mTOR signaling in cancer. Front Oncol 4: 64, 2014.
    • (2014) Front Oncol , vol.4 , pp. 64
    • Porta, C.1    Paglino, C.2    Mosca, A.3
  • 23
    • 77956236877 scopus 로고    scopus 로고
    • PI(3)king apart PTEN's role in cancer
    • Zhang S and Yu D: PI(3)king apart PTEN's role in cancer. Clin Cancer Res 16: 4325-4330, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 4325-4330
    • Zhang, S.1    Yu, D.2
  • 24
    • 2442498583 scopus 로고    scopus 로고
    • Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
    • Mahimainathan L and Choudhury GG: Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J Biol Chem 279: 15258-15268, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 15258-15268
    • Mahimainathan, L.1    Choudhury, G.G.2
  • 25
    • 34548299547 scopus 로고    scopus 로고
    • FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
    • Yoshimoto M, Cunha IW, Coudry RA, Fonseca FP, Torres CH, Soares FA and Squire JA: FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer 97: 678-685, 2007.
    • (2007) Br J Cancer , vol.97 , pp. 678-685
    • Yoshimoto, M.1    Cunha, I.W.2    Coudry, R.A.3    Fonseca, F.P.4    Torres, C.H.5    Soares, F.A.6    Squire, J.A.7
  • 26
    • 0032977124 scopus 로고    scopus 로고
    • Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
    • Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC and Van Meir EG: Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 9: 469-479, 1999.
    • (1999) Brain Pathol , vol.9 , pp. 469-479
    • Ishii, N.1    Maier, D.2    Merlo, A.3    Tada, M.4    Sawamura, Y.5    Diserens, A.C.6    Van Meir, E.G.7
  • 27
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T and Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 28
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke TF, Kaplan DR, Cantley LC and Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275: 665-668, 1997.
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 29
  • 32
    • 79956150420 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA): A key factor in DNA replication and cell cycle regulation
    • Strzalka W and Ziemienowicz A: Proliferating cell nuclear antigen (PCNA): A key factor in DNA replication and cell cycle regulation. Ann Bot 107: 1127-1140, 2011.
    • (2011) Ann Bot , vol.107 , pp. 1127-1140
    • Strzalka, W.1    Ziemienowicz, A.2
  • 33
    • 84919880342 scopus 로고    scopus 로고
    • TGF-beta induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer
    • Singha PK, Pandeswara S, Geng H, Lan R, Venkatachalam MA and Saikumar P: TGF-beta induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer. Genes Cancer 5: 320-336, 2014.
    • (2014) Genes Cancer , vol.5 , pp. 320-336
    • Singha, P.K.1    Pandeswara, S.2    Geng, H.3    Lan, R.4    Venkatachalam, M.A.5    Saikumar, P.6
  • 34
    • 84929028454 scopus 로고    scopus 로고
    • High efficacy of combination therapy using PI3K/AKT inhibitors with androgen deprivation in prostate cancer preclinical models
    • Sep 11, (Epub ahead of print)
    • Marques RB, Aghai A, de Ridder CM, Stuurman D, Hoeben S, Boer A, Ellston RP, Barry ST, Davies BR, Trapman J, et al: High efficacy of combination therapy using PI3K/AKT inhibitors with androgen deprivation in prostate cancer preclinical models. Eur Urol: Sep 11, 2014 (Epub ahead of print) doi: 10.1016/j. eururo.2014.08.053.
    • (2014) Eur Urol
    • Marques, R.B.1    Aghai, A.2    De Ridder, C.M.3    Stuurman, D.4    Hoeben, S.5    Boer, A.6    Ellston, R.P.7    Barry, S.T.8    Davies, B.R.9    Trapman, J.10
  • 35
    • 84927144458 scopus 로고    scopus 로고
    • MicroRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway
    • Wang J, Chu ES, Chen HY, Man K, Go MY, Huang XR, Lan HY, Sung JJ and Yu J: microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway. Oncotarget 6: 7325-7338, 2014.
    • (2014) Oncotarget , vol.6 , pp. 7325-7338
    • Wang, J.1    Chu, E.S.2    Chen, H.Y.3    Man, K.4    Go, M.Y.5    Huang, X.R.6    Lan, H.Y.7    Sung, J.J.8    Yu, J.9
  • 36
    • 84930883311 scopus 로고    scopus 로고
    • NSK-01105 inhibits proliferation and induces apoptosis of prostate cancer cells by blocking the Raf/MEK/ERK and PI3K/Akt/mTOR signal pathways
    • Yu P, Ye L, Wang H, Du G, Zhang J, Zhang J and Tian J: NSK-01105 inhibits proliferation and induces apoptosis of prostate cancer cells by blocking the Raf/MEK/ERK and PI3K/Akt/mTOR signal pathways. Tumour Biol 36: 2143-2153, 2015.
    • (2015) Tumour Biol , vol.36 , pp. 2143-2153
    • Yu, P.1    Ye, L.2    Wang, H.3    Du, G.4    Zhang, J.5    Zhang, J.6    Tian, J.7
  • 40
    • 33845543110 scopus 로고    scopus 로고
    • Gastroprotective effect of fructus evodiae water extract on ethanol-induced gastric lesions in rats
    • Yu X, Wu DZ, Yuan JY, Zhang RR and Hu ZB: Gastroprotective effect of fructus evodiae water extract on ethanol-induced gastric lesions in rats. Am J Chin Med 34: 1027-1035, 2006.
    • (2006) Am J Chin Med , vol.34 , pp. 1027-1035
    • Yu, X.1    Wu, D.Z.2    Yuan, J.Y.3    Zhang, R.R.4    Hu, Z.B.5
  • 41
    • 19844377252 scopus 로고    scopus 로고
    • Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo
    • Liao CH, Pan SL, Guh JH, Chang YL, Pai HC, Lin CH and Teng CM: Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis 26: 968-975, 2005.
    • (2005) Carcinogenesis , vol.26 , pp. 968-975
    • Liao, C.H.1    Pan, S.L.2    Guh, J.H.3    Chang, Y.L.4    Pai, H.C.5    Lin, C.H.6    Teng, C.M.7
  • 42
    • 67249138744 scopus 로고    scopus 로고
    • Evodiamine: A novel anti-cancer alkaloid from Evodia rutaecarpa
    • Jiang J and Hu C: Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa. Molecules 14: 1852-1859, 2009.
    • (2009) Molecules , vol.14 , pp. 1852-1859
    • Jiang, J.1    Hu, C.2
  • 43
    • 20444504721 scopus 로고    scopus 로고
    • Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, upregulating apoptosis, and inhibiting invasion
    • Takada Y, Kobayashi Y and Aggarwal BB: Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, upregulating apoptosis, and inhibiting invasion. J Biol Chem 280: 17203-17212, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 17203-17212
    • Takada, Y.1    Kobayashi, Y.2    Aggarwal, B.B.3
  • 44
    • 84903541364 scopus 로고    scopus 로고
    • Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine
    • Chien CC, Wu MS, Shen SC, Ko CH, Chen CH, Yang LL and Chen YC: Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine. PLoS One 9: e99729, 2014.
    • (2014) PLoS One , vol.9 , pp. e99729
    • Chien, C.C.1    Wu, M.S.2    Shen, S.C.3    Ko, C.H.4    Chen, C.H.5    Yang, L.L.6    Chen, Y.C.7
  • 47
    • 84874609274 scopus 로고    scopus 로고
    • Pharmacological actions of multi-target-directed evodiamine
    • Yu H, Jin H, Gong W, Wang Z and Liang H: Pharmacological actions of multi-target-directed evodiamine. Molecules 18: 1826-1843, 2013.
    • (2013) Molecules , vol.18 , pp. 1826-1843
    • Yu, H.1    Jin, H.2    Gong, W.3    Wang, Z.4    Liang, H.5
  • 48
    • 84880181768 scopus 로고    scopus 로고
    • Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells
    • Liu AJ, Wang SH, Chen KC, Kuei HP, Shih YL, Hou SY, Chiu WT, Hsiao SH and Shih CM: Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells. Chem Biol Interact 205: 20-28, 2013.
    • (2013) Chem Biol Interact , vol.205 , pp. 20-28
    • Liu, A.J.1    Wang, S.H.2    Chen, K.C.3    Kuei, H.P.4    Shih, Y.L.5    Hou, S.Y.6    Chiu, W.T.7    Hsiao, S.H.8    Shih, C.M.9
  • 49
    • 77649178970 scopus 로고    scopus 로고
    • Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition
    • Wang C, Li S and Wang MW: Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition. Toxicol In Vitro 24: 898-904, 2010.
    • (2010) Toxicol in Vitro , vol.24 , pp. 898-904
    • Wang, C.1    Li, S.2    Wang, M.W.3
  • 50
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali IU, Schriml LM and Dean M: Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91: 1922-1932, 1999.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3


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