A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Bhujbal, Swapnil V ^a,b   De Haan, Bart ^a   Niclou, Simone P ^b   De Vos, Paul ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; GLUCURONIC ACID; HEXURONIC ACID; MICROCAPSULE;

ANIMAL; CELL LINE; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; DRUG EFFECTS; DRUG FORMULATION; MECHANICS; MICROCAPSULE; PROCEDURES;

ALGINATES; ANIMALS; CAPSULES; CELL LINE; CELL PROLIFERATION; CELL SURFACE EXTENSIONS; CELL SURVIVAL; DRUG COMPOUNDING; GLUCURONIC ACID; HEXURONIC ACIDS; MECHANICAL PHENOMENA;

EID: 84937226026     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep06856     Document Type: Article

References (60)

1. De Vos, P., Faas, M. M., Strand, B. & Calafiore, R. Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials 27, 5603-5617 (2006).
2. Kulseng, B., Thu, B., Espevik, T., Skjak-Braek, G. & Skjåk-Braek, G. Alginate polylysine microcapsules as immune barrier: permeability of cytokines and immunoglobulins over the capsule membrane. Cell Transplant. 6, 387-394 (1997).
3. Jacobs-Tulleneers-Thevissen, D. et al. Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient. Diabetologia 56, 1605-14 (2013).
4. Jo K. Utvik & Simone, P. Niclou. in Bioartifical Pancreas other Biohybrid Ther. (Hallé, J.-P., Vos, P. De & Rosenberg, L.) 607-613 (Transworld Research Network, 2009).
5. Garcia, P. et al. Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease. J. Neurosci. 30, 7516-7527 (2010).
6. Emerich, D. F. & Salzberg, H. C. Update on immunoisolation cell therapy for CNS diseases. Cell Transplant. 10, 3-24 (2001).
7. Emerich, D. F. et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386, 395-399 (1997).
8. Read, T. A. et al. Local endostatin treatment of gliomas administered by microencapsulated producer cells. Nat. Biotechnol. 19, 29-34 (2001).
9. Johansson, M. et al. The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status. Neuro. Oncol. 15, 1200-11 (2013).
10. Lohr, M. et al. Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma. Lancet 357, 1591-1592 (2001).
11. Zimmermann, U. C., Jork, H., Thürmer, A., Zimmermann, F., Fuhr, H., Hasse, G. & Rothmund, C. M. in Biotechnol. Spec. Process. (H.J. Rehm, G. R.) 547-571 (Wiley-VCH Verlag GmbH, 2008).
12. Prüsse, U. et al. Comparison of different technologies for alginate beads production. Chem. Pap. 62, 364-374 (2008).
13. Bhujbal, S. V., de Vos, P. & Niclou, S. P. Drug and Cell Encapsulation: Alternative Delivery Options for the Treatment of Malignant Brain Tumors. Adv. Drug Deliv. Rev. 67-68, 142-53 (2014).
14. Terzis, A. J. A., Niclou, S. P., Rajcevic, U., Danzeisen, C. & Bjerkvig, R. Cell therapies for glioblastoma. Expert Opin. Biol. Ther. 6, 739-49 (2006).
15. De Haan, B. J., Faas, M. M. & de Vos, P. Factors influencing insulin secretion from encapsulated islets. Cell Transplant. 12, 617-25 (2003).
16. Uludag, H., De Vos, P. & Tresco, P. A. Technology of mammalian cell encapsulation. Adv. Drug Deliv. Rev. 42, 29-64 (2000).
17. De Vos, P., Lazarjani, H. A., Poncelet, D. & Faas, M. M. Polymers in cell encapsulation from an enveloped cell perspective. Adv. Drug Deliv. Rev. (2013).
18. Stabler, C., Wilks, K., Sambanis, A. & Constantinidis, I. The effects of alginate composition on encapsulated betaTC3 cells. Biomaterials 22, 1301-10 (2001).
19. Bhujbal, S. V., Paredes-Juarez, G. A., Niclou, S. P. & de Vos, P. Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells. J. Mech. Behav. Biomed. Mater. 37C, 196-208 (2014).
20. Joki, T. et al. Continuous release of endostatin from microencapsulated engineered cells for tumor therapy. Nat. Biotechnol. 19, 35-9 (2001).
21. Bunger, C. M. et al. Biocompatibility and surface structure of chemically modified immunoisolating alginate-PLL capsules. J. Biomed. Mater. Res. A 67, 1219-1227 (2003).
22. Orr, A. W., Helmke, B. P., Blackman, B. R. & Schwartz, M. A. Mechanisms of mechanotransduction. Dev. Cell 10, 11-20 (2006).
23. García, J. R. & García, A. J. Cellular mechanotransduction: Sensing rigidity. Nat. Mater. 13, 539-40 (2014).
24. Huselstein, C. et al. Influence of mechanical stress on cell viability. Biorheology 43, 371-5 (2006).
25. Constantinidis, I., Rask, I., Long, R. C. & Sambanis, A. Effects of alginate composition on the metabolic, secretory, and growth characteristics of entrapped beta TC3 mouse insulinoma cells. Biomaterials 20, 2019-27 (1999).
26. Haug, A. & Smidsrød, O. Selectivity of Some Anionic Polymers for Divalent Metal Ions. Acta Chem. Scand 3, 843-854 (1970).
27. Mørch, Y. A., Donati, I., Strand, B. L. & Skjak-Braek, G. Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads. Biomacromolecules 7, 1471-1480 (2006).
28. Chan, E.-S. et al. Effect of formulation of alginate beads on their mechanical behavior and stiffness. Particuology 9, 228-234 (2011).
29. Goldmann, W. H. Mechanotransduction in cells. Cell Biol. Int. 36, 567-70 (2012).
30. Ross, T. D. et al. Integrins in mechanotransduction. Curr. Opin. Cell Biol. 25, 613-8 (2013).
31. Puklin-Faucher, E. & Sheetz, M. P. The mechanical integrin cycle. J. Cell Sci. 122, 179-86 (2009).
32. Matthews, B. D., Overby, D. R., Mannix, R. & Ingber, D. E. Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell Sci. 119, 508-18 (2006).
33. Huang, X. et al. Matrix stiffness in three-dimensional systems effects on the behavior of C3A cells. Artif. Organs 37, 166-74 (2013).
34. Tam, S. K. et al. Biocompatibility and physicochemical characteristics of alginatepolycation microcapsules. Acta Biomater. 7, 1683-92 (2011).
35. Vos, P. De. et al Effect of the alginate composition on the biocompatibility of alginate-polylysine microcapsules. Biomaterials 18, 273-278 (1997).
36. Orive, G., Tam, S. K., Pedraz, J. L. J. L., Hallé, J.-P. & Hallé, J.-P. Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy. Biomaterials 27, 3691-700 (2006).
37. Tam, S. K. et al. Factors influencing alginate gel biocompatibility. J. Biomed. Mater. Res. A 98, 40-52 (2011).
38. De Vos, P. et al. Multiscale requirements for bioencapsulation in medicine and biotechnology. Biomaterials 30, 2559-70 (2009).
39. De Vos, P., de Haan, B. J., Kamps, J. A. A. M., Faas, M. M. & Kitano, T. Zetapotentials of alginate-PLL capsules: a predictive measure for biocompatibility? J. Biomed. Mater. Res. A 80, 813-9 (2007).
40. De Vos, P., Hoogmoed, C. G. & Busscher, H. J. Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells. J. Biomed. Mater. Res. 60, 252-9 (2002).
41. De Vos, P., van Hoogmoed, C. G., de Haan, B. J. & Busscher, H. J. Tissue responses against immunoisolating alginate-PLL capsules in the immediate posttransplant period. J. Biomed. Mater. Res. 62, 430-437 (2002).
42. Strand, B. L. et al. Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties. J. Microencapsul. 19, 615-630 (2002).
43. Strand, B. L. et al. Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines. Cell Transplant. 10, 263-275 (2001).
44. Juste, S., Lessard, M., Henley, N., Ménard, M. & Hallé, J.-P. Effect of poly-L-lysine coating on macrophage activation by alginate-based microcapsules: assessment using a new in vitro method. J. Biomed. Mater. Res. A 72, 389-98 (2005).
45. Vandenbossche, G. M. et al. Host reaction against empty alginate-polylysine microcapsules. Influence of preparation procedure. J. Pharm. Pharmacol. 45, 115-120 (1993).
46. Zhao, W. et al. Oxygen diffusivity in alginate/chitosan microcapsules. J. Chem. Technol. Biotechnol. 88, 449-455 (2013).
47. Kuijlen, J. M. et al. The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors. J. Neurooncol. 78, 31-39 (2006).
48. De Vos, P., Spasojevic, M., de Haan, B. J. & Faas, M. M. The association between in vivo physicochemical changes and inflammatory responses against alginate based microcapsules. Biomaterials 33, 5552-9 (2012).
49. Thu, B. et al. Inhomogeneous alginate gel spheres: an assessment of the polymer gradients by synchrotron radiation-induced X-ray emission, magnetic resonance microimaging, and mathematical modeling. Biopolymers 53, 60-71 (2000).
50. Thu, B., Skjåk-Bræk, G., Micali, F., Vittur, F. & Rizzo, R. The spatial distribution of calcium in alginate gel beads analysed by synchrotron-radiation induced X-ray emission (SRIXE). Carbohydr. Res. 297, 101-105 (1997).
51. Machida-Sano, I. et al. Surface characteristics determining the cell compatibility of ionically cross-linked alginate gels. Biomed. Mater. 9, 025007 (2014).
52. Lekka, M., Sainz-Serp, D., Kulik, A. J. & Wandrey, C. Hydrogel microspheres: influence of chemical composition on surface morphology, local elastic properties, and bulk mechanical characteristics. Langmuir 20, 9968-77 (2004).
53. De Vos, P., De Haan, B., Pater, J. & Van Schilfgaarde, R. Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. Transplantation 62, 893-899 (1996).
54. De Vos, P., De Haan, B. J., Wolters, G. H., Strubbe, J. H. & Van Schilfgaarde, R. Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets. Diabetologia 40, 262-270 (1997).
55. Zimmermann, H. et al. Physical and biological properties of barium cross-linked alginate membranes. Biomaterials 28, 1327-45 (2007).
56. Albrecht, K., Christian, S., Jörg, B., Birgit, K. & Jörg, K. in Acoust. Imaging (Maev, R. G.) 223-229 (Plenum Publishers, New York, 2002). doi:10.1007/978-1-4419-8606-1-29.
57. Wang, C. X., Cowen, C., Zhang, Z. & Thomas, C. R. High-speed compression of single alginate microspheres. Chem. Eng. Sci. 60, 6649-6657 (2005).
58. De Vos, P., De Haan, B. J. & Van Schilfgaarde, R. Upscaling the production of microencapsulated pancreatic islets. Biomaterials 18, 1085-90 (1997).
59. Van Schilfgaarde, R. & de Vos, P. Factors influencing the properties and performance of microcapsules for immunoprotection of pancreatic islets. J. Mol. Med. (Berl). 77, 199-205 (1999).
60. Siedlecki, C. A. & Marchant, R. E. Atomic force microscopy for characterization of the biomaterial interface. Biomaterials 19, 441-54 (1998).