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Volumn 185, Issue 6, 2013, Pages 485-492

Emerging therapies for acute traumatic spinal cord injury

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; CETHRIN; CHONDROITIN ABC LYASE; FIBROBLAST GROWTH FACTOR 2; GM 1; MAGNESIUM POLYETHYLENE GLYCOL; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; MINOCYCLINE; NALOXONE; NEUROPROTECTIVE AGENT; NEUROREGENERATIVE AGENT; NIMODIPINE; NOGO INHIBITOR; PLACEBO; RHO INHIBITOR; RILUZOLE; TIRILAZAD; UNCLASSIFIED DRUG;

EID: 84876857783     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.121206     Document Type: Review
Times cited : (161)

References (52)
  • 1
    • 84860569657 scopus 로고    scopus 로고
    • The incidence and prevalence of spinal cord injury in Canada: A national perspective
    • Noonan VK, Fingas M, Farry A, et al. The incidence and prevalence of spinal cord injury in Canada: a national perspective. Neuroepidemiology 2012;38:219-26.
    • (2012) Neuroepidemiology , vol.38 , pp. 219-226
    • Noonan, V.K.1    Fingas, M.2    Farry, A.3
  • 3
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 1991;75:15-26.
    • (1991) J Neurosurg , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 4
    • 0036454326 scopus 로고    scopus 로고
    • Secondary injury mechanisms of spinal cord trauma: A novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole
    • Schwartz G, Fehlings M. Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res 2002;137:177-90.
    • (2002) Prog Brain Res , vol.137 , pp. 177-190
    • Schwartz, G.1    Fehlings, M.2
  • 5
    • 38649112309 scopus 로고    scopus 로고
    • CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
    • Fitch MT, Silver J. CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 2008;209:294-301.
    • (2008) Exp Neurol , vol.209 , pp. 294-301
    • Fitch, M.T.1    Silver, J.2
  • 6
    • 79955961172 scopus 로고    scopus 로고
    • A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury
    • Fehlings MG, Theodore N, Harrop J, et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma 2011;28:787-96.
    • (2011) J Neurotrauma , vol.28 , pp. 787-796
    • Fehlings, M.G.1    Theodore, N.2    Harrop, J.3
  • 7
    • 79955061639 scopus 로고    scopus 로고
    • Emerging approaches to the surgical management of acute traumatic Spinal Cord Injury
    • Wilson JR, Fehlings MG. Emerging approaches to the surgical management of acute traumatic Spinal Cord Injury. Neurotherapeutics 2011;8:187-94.
    • (2011) Neurotherapeutics , vol.8 , pp. 187-194
    • Wilson, J.R.1    Fehlings, M.G.2
  • 8
    • 0027516794 scopus 로고
    • The role of secondary brain injury in determining outcome from severe head injury
    • Chesnut RM, Marshall L, Klauber M, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993;34:216-22.
    • (1993) J Trauma , vol.34 , pp. 216-222
    • Chesnut, R.M.1    Marshall, L.2    Klauber, M.3
  • 9
    • 0027444727 scopus 로고
    • Hemodynamic parameters in patients with acute cervical cord trauma: Description, intervention, and prediction of outcome
    • Levi L, Wolf A, Belzber H. Hemodynamic parameters in patients with acute cervical cord trauma: description, intervention, and prediction of outcome. Neurosurgery 1993;33:1007-10167.
    • (1993) Neurosurgery , vol.33 , pp. 1007-10167
    • Levi, L.1    Wolf, A.2    Belzber, H.3
  • 10
    • 0036490794 scopus 로고    scopus 로고
    • Blood pressure management after acute spinal cord injury
    • Blood pressure management after acute spinal cord injury. Neurosurgery 2002;50:S58-62.
    • (2002) Neurosurgery , vol.50
  • 11
    • 0042281593 scopus 로고    scopus 로고
    • Management of acute spinal cord injuries in an intensive care unit or other monitored setting
    • Management of acute spinal cord injuries in an intensive care unit or other monitored setting. Neurosurgery 2002; (Suppl 3): S51-7.
    • (2002) Neurosurgery , Issue.SUPPL. 3
  • 12
    • 79960803075 scopus 로고    scopus 로고
    • Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: An evidence-based examination of pre-clinical and clinical studies
    • Furlan JC, Noonan V, Cadotte DW, et al. Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: an evidence-based examination of pre-clinical and clinical studies. J Neurotrauma 2011;28:1371-99.
    • (2011) J Neurotrauma , vol.28 , pp. 1371-1399
    • Furlan, J.C.1    Noonan, V.2    Cadotte, D.W.3
  • 13
    • 84907041580 scopus 로고
    • The management of spinal injuries - Past and present
    • Bedbrook GM, Sedgley GI. The management of spinal injuries - past and present. Int Rehabil Med 1980;2:45-61.
    • (1980) Int Rehabil Med , vol.2 , pp. 45-61
    • Bedbrook, G.M.1    Sedgley, G.I.2
  • 14
    • 33646785751 scopus 로고    scopus 로고
    • The timing of surgical intervention in the treatment of spinal cord injury: A systematic review of recent clinical evidence
    • discussion S6
    • Fehlings MG, Perrin RG. The timing of surgical intervention in the treatment of spinal cord injury: a systematic review of recent clinical evidence. Spine (Phila Pa 1976). 2006;31(Suppl 11):S28-35; discussion S6.
    • (2006) Spine (Phila Pa 1976) , vol.31 , Issue.SUPPL. 11
    • Fehlings, M.G.1    Perrin, R.G.2
  • 15
    • 84859320748 scopus 로고    scopus 로고
    • Early versus delayed decompression for traumatic cervical spinal cord injury: Results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)
    • Fehlings MG, Vaccaro A, Wilson J, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS ONE 2012;7:e32037.
    • (2012) PLoS ONE , vol.7
    • Fehlings, M.G.1    Vaccaro, A.2    Wilson, J.3
  • 16
    • 77957991863 scopus 로고    scopus 로고
    • Current practice in the timing of surgical intervention in spinal cord injury
    • Fehlings MG, Rabin D, Sears W, et al. Current practice in the timing of surgical intervention in spinal cord injury. Spine 2010;35:S166-73.
    • (2010) Spine , vol.35
    • Fehlings, M.G.1    Rabin, D.2    Sears, W.3
  • 17
    • 66149096703 scopus 로고    scopus 로고
    • Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats
    • Lo TP Jr, Cho KS, Garg MS, et al. Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats. J Comp Neurol 2009;514:433-48.
    • (2009) J Comp Neurol , vol.514 , pp. 433-448
    • Lo Jr., T.P.1    Cho, K.S.2    Garg, M.S.3
  • 18
    • 77950003988 scopus 로고    scopus 로고
    • Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury
    • Levi AD, Casella G, Green BA, et al. Clinical outcomes using modest intravascular hypothermia after acute cervical spinal cord injury. Neurosurgery 2010;66:670-7.
    • (2010) Neurosurgery , vol.66 , pp. 670-677
    • Levi, A.D.1    Casella, G.2    Green, B.A.3
  • 19
    • 0025344617 scopus 로고
    • A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study
    • Bracken MB, Shepard M, Collins W, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 1990;322:1405-11.
    • (1990) N Engl J Med , vol.322 , pp. 1405-1411
    • Bracken, M.B.1    Shepard, M.2    Collins, W.3
  • 20
    • 0001335907 scopus 로고
    • Beneficial effects of methylprednisolone sodium succinate in the treatment of acute spinal cord injury
    • Otani K, Abe H, Kadoya S. Beneficial effects of methylprednisolone sodium succinate in the treatment of acute spinal cord injury. Sekitsy Sekizui 1994;7:633-47.
    • (1994) Sekitsy Sekizui , vol.7 , pp. 633-647
    • Otani, K.1    Abe, H.2    Kadoya, S.3
  • 22
    • 1642422176 scopus 로고    scopus 로고
    • Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study
    • Bracken MB, Shepard M, Holford T, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997;277:1597-604.
    • (1997) JAMA , vol.277 , pp. 1597-1604
    • Bracken, M.B.1    Shepard, M.2    Holford, T.3
  • 23
    • 0035893918 scopus 로고    scopus 로고
    • The Sygen multicenter acute spinal cord injury study
    • Geisler FH, Coleman W, Grieco G, et al. The Sygen multicenter acute spinal cord injury study. Spine 2001;26:S87-98.
    • (2001) Spine , vol.26
    • Geisler, F.H.1    Coleman, W.2    Grieco, G.3
  • 24
    • 0021255932 scopus 로고
    • Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism
    • Braughler JM, Hall E. Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. J Neurosurg 1984;61:290-5.
    • (1984) J Neurosurg , vol.61 , pp. 290-295
    • Braughler, J.M.1    Hall, E.2
  • 25
  • 26
    • 0342647473 scopus 로고    scopus 로고
    • Methylprednisolone for acute spinal cord injury: An inappropriate standard of care
    • Hurlbert RJ. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg 2000;93:1-7.
    • (2000) J Neurosurg , vol.93 , pp. 1-7
    • Hurlbert, R.J.1
  • 27
    • 0036687701 scopus 로고    scopus 로고
    • High-dose methylprednisilone for acute closed spinal cord injury - Only a treatment option
    • Hugenholtz H, Cass D, Dvorak M. High-dose methylprednisilone for acute closed spinal cord injury - only a treatment option. Can J Neurol Sci 2002;3:227-35.
    • (2002) Can J Neurol Sci , vol.3 , pp. 227-235
    • Hugenholtz, H.1    Cass, D.2    Dvorak, M.3
  • 28
    • 0027458009 scopus 로고
    • The effect of long-term high-dose naloxone infusion in experimental blunt spinal cord injury
    • Baskin DS, Simpson RK Jr, Browning JL, et al. The effect of long-term high-dose naloxone infusion in experimental blunt spinal cord injury. J Spinal Disord 1993;6:38-43.
    • (1993) J Spinal Disord , vol.6 , pp. 38-43
    • Baskin, D.S.1    Simpson Jr., R.K.2    Browning, J.L.3
  • 29
    • 0024326071 scopus 로고
    • The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury
    • Fehlings MG, Tator CH, Linden RD. The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg 1989;71:403-16.
    • (1989) J Neurosurg , vol.71 , pp. 403-416
    • Fehlings, M.G.1    Tator, C.H.2    Linden, R.D.3
  • 30
    • 0022572610 scopus 로고
    • Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cord - Transected rats
    • Bose B, Osterholm J, Kalia M. Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cord - transected rats. Neurosci Lett 1986;63:165-9.
    • (1986) Neurosci Lett , vol.63 , pp. 165-169
    • Bose, B.1    Osterholm, J.2    Kalia, M.3
  • 31
    • 34250208597 scopus 로고    scopus 로고
    • Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
    • Miller RG, Mitchell JD, Lyon M. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev 2007; (1): CD001447.
    • (2007) Cochrane Database Syst Rev , Issue.1
    • Miller, R.G.1    Mitchell, J.D.2    Lyon, M.3
  • 32
    • 84872202507 scopus 로고    scopus 로고
    • Riluzole for the treatment of acute traumatic spinal cord injury: Rationale for and design of the NACTN Phase I Clinical Trial
    • Fehlings MG, Wilson JR, Frankowski RF, et al. Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I Clinical Trial. J Neurosurg Spine 2012;17:151-6.
    • (2012) J Neurosurg Spine , vol.17 , pp. 151-156
    • Fehlings, M.G.1    Wilson, J.R.2    Frankowski, R.F.3
  • 34
    • 33646598662 scopus 로고    scopus 로고
    • Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury
    • Festoff BW, Ameenuddin S, Arnold PM, et al. Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. J Neurochem 2006;97:1314-26.
    • (2006) J Neurochem , vol.97 , pp. 1314-1326
    • Festoff, B.W.1    Ameenuddin, S.2    Arnold, P.M.3
  • 35
    • 84860146607 scopus 로고    scopus 로고
    • Results of a phase II placebo-controlled randomized trial of minocylcine in acute spinal cord injury
    • Casha S, Zygun D, McGowan M, et al. Results of a phase II placebo-controlled randomized trial of minocylcine in acute spinal cord injury. Brain 2012;135:1224-36.
    • (2012) Brain , vol.135 , pp. 1224-1236
    • Casha, S.1    Zygun, D.2    McGowan, M.3
  • 36
    • 0006495387 scopus 로고    scopus 로고
    • Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury
    • Teng YD, Mocchetti I, Taveira-DaSilva AM, et al. Basic fibroblast growth factor increases long-term survival of spinal motor neurons and improves respiratory function after experimental spinal cord injury. J Neurosci 1999;19:7037-47.
    • (1999) J Neurosci , vol.19 , pp. 7037-7047
    • Teng, Y.D.1    Mocchetti, I.2    Taveira-DaSilva, A.M.3
  • 37
    • 0032563211 scopus 로고    scopus 로고
    • Identification and characterization of a bovine neurite growth inhibitor (bNI-220)
    • Spillmann AA, Bandtlow CE, Lottspeich F, et al. Identification and characterization of a bovine neurite growth inhibitor (bNI-220). J Biol Chem 1998;273:19283-93.
    • (1998) J Biol Chem , vol.273 , pp. 19283-19293
    • Spillmann, A.A.1    Bandtlow, C.E.2    Lottspeich, F.3
  • 38
    • 34248353098 scopus 로고    scopus 로고
    • Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey
    • Freund P, Wannier T, Schmidlin E, et al. Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey. J Comp Neurol 2007;502:644-59.
    • (2007) J Comp Neurol , vol.502 , pp. 644-659
    • Freund, P.1    Wannier, T.2    Schmidlin, E.3
  • 39
    • 77954862426 scopus 로고    scopus 로고
    • Stem cell therapies for spinal cord injury
    • Sahni V, Kessler JA. Stem cell therapies for spinal cord injury. Nat Rev Neurol 2010;6:363-72.
    • (2010) Nat Rev Neurol , vol.6 , pp. 363-372
    • Sahni, V.1    Kessler, J.A.2
  • 40
    • 62549145360 scopus 로고    scopus 로고
    • Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: Comprehensive case studies
    • Geffner LF, Santacruz P, Izurieta M, et al. Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant 2008;17:1277-93.
    • (2008) Cell Transplant , vol.17 , pp. 1277-1293
    • Geffner, L.F.1    Santacruz, P.2    Izurieta, M.3
  • 41
    • 34547915244 scopus 로고    scopus 로고
    • Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial
    • Yoon SH, Shim YS, Park YH, et al. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: phase I/II clinical trial. Stem Cells 2007;25:2066-73.
    • (2007) Stem Cells , vol.25 , pp. 2066-2073
    • Yoon, S.H.1    Shim, Y.S.2    Park, Y.H.3
  • 42
    • 33846240478 scopus 로고    scopus 로고
    • Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury
    • Syková E, Homola A, Mazanec R, et al. Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant 2006;15:675-87.
    • (2006) Cell Transplant , vol.15 , pp. 675-687
    • Syková, E.1    Homola, A.2    Mazanec, R.3
  • 43
    • 53749099516 scopus 로고    scopus 로고
    • Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hema topoietic stem cell transplantation: 1-year follow-up
    • Deda H, Inci MC, Kurekci AE, et al. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hema topoietic stem cell transplantation: 1-year follow-up. Cytotherapy 2008;10:565-74.
    • (2008) Cytotherapy , vol.10 , pp. 565-574
    • Deda, H.1    Inci, M.C.2    Kurekci, A.E.3
  • 44
    • 50849127500 scopus 로고    scopus 로고
    • Autologous olfactory ensheathing cell transplantation in human paraplegia: A 3-year clinical trial
    • Mackay-Sim A, Feron F, Cochrane J, et al. Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain 2008;131:2376-86.
    • (2008) Brain , vol.131 , pp. 2376-2386
    • Mackay-Sim, A.1    Feron, F.2    Cochrane, J.3
  • 45
    • 77649212204 scopus 로고    scopus 로고
    • Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury
    • Lima C, Escada P, Pratas-Vital J, et al. Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury. Neurorehabil Neural Repair 2010;24:10-22.
    • (2010) Neurorehabil Neural Repair , vol.24 , pp. 10-22
    • Lima, C.1    Escada, P.2    Pratas-Vital, J.3
  • 46
    • 49149084937 scopus 로고    scopus 로고
    • Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: An interim report on safety considerations and possible outcomes
    • Saberi H, Moshayedi P, Aghayan HR, et al. Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible outcomes. Neurosci Lett 2008;443:46-50.
    • (2008) Neurosci Lett , vol.443 , pp. 46-50
    • Saberi, H.1    Moshayedi, P.2    Aghayan, H.R.3
  • 47
    • 27244435547 scopus 로고    scopus 로고
    • Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results
    • Knoller N, Auerbach G, Fulga V, et al. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. J Neurosurg Spine 2005;3:173-81.
    • (2005) J Neurosurg Spine , vol.3 , pp. 173-181
    • Knoller, N.1    Auerbach, G.2    Fulga, V.3
  • 48
    • 84866512164 scopus 로고    scopus 로고
    • Autologous incubated macrophage therapy in acute, complete spinal cord injury: Results of the phase 2 randomized controlled multicenter trial
    • Lammertse D P, Jones LA, Charlifue SB, et al. Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial. Spinal Cord 2012;50:661-71.
    • (2012) Spinal Cord , vol.50 , pp. 661-671
    • Lammertse, D.P.1    Jones, L.A.2    Charlifue, S.B.3
  • 49
    • 79951772039 scopus 로고    scopus 로고
    • Manipulating the glial scar: Chondroitin ase ABC as a therapy for spinal cord injury
    • Bradbury EJ, Carter LM. Manipulating the glial scar: chondroitin ase ABC as a therapy for spinal cord injury. Brain Res Bull 2011;84:306-16.
    • (2011) Brain Res Bull , vol.84 , pp. 306-316
    • Bradbury, E.J.1    Carter, L.M.2
  • 50
    • 0036797055 scopus 로고    scopus 로고
    • Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury
    • Luo J, Borgens R, Shi R. Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury. J Neurochem 2002;83:471-80.
    • (2002) J Neurochem , vol.83 , pp. 471-480
    • Luo, J.1    Borgens, R.2    Shi, R.3
  • 51
    • 33846314024 scopus 로고    scopus 로고
    • Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons
    • Das M, Patil S, Bhargava N, et al. Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons. Biomaterials 2007;28:1918-25.
    • (2007) Biomaterials , vol.28 , pp. 1918-1925
    • Das, M.1    Patil, S.2    Bhargava, N.3
  • 52
    • 79958092638 scopus 로고    scopus 로고
    • Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: A case study
    • Harkema S, Gerasimenko Y, Hodes J, et al. Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet 2011;377:1938-47.
    • (2011) Lancet , vol.377 , pp. 1938-1947
    • Harkema, S.1    Gerasimenko, Y.2    Hodes, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.