Early versus delayed decompression for traumatic cervical spinal cord injury: Results of the surgical timing in acute spinal cord injury study (STASCIS)

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Fehlings, Michael G ^a   Vaccaro, Alexander ^b   Wilson, Jefferson R ^a   Singh, Anoushka ^a   Cadotte, David W ^a   Harrop, James S ^b   Aarabi, Bizhan ^c   Shaffrey, Christopher ^d   Dvorak, Marcel ^e   Fisher, Charles ^e   Arnold, Paul ^f   Massicotte, Eric M ^a   Lewis, Stephen ^a   Rampersaud, Raja ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEROID;

ADOLESCENT; ADULT; AGED; ARTICLE; ASIA IMPAIRMENT SCALE; CERVICAL SPINAL CORD INJURY; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED SPINAL CORD DECOMPRESSION; EARLY SPINAL CORD DECOMPRESSION; FEMALE; FOLLOW UP; HEALTH STATUS; HEART INFARCTION; HUMAN; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; POSTOPERATIVE COMPLICATION; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; RATING SCALE; SPINAL CORD DECOMPRESSION; CERVICAL SPINE; CLINICAL TRIAL; DECOMPRESSION SURGERY; INJURY; INTERNATIONAL COOPERATION; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; SPINAL CORD INJURY; TIME; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CERVICAL VERTEBRAE; COHORT STUDIES; DECOMPRESSION, SURGICAL; FEMALE; HUMANS; INTERNATIONAL COOPERATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SPINAL CORD INJURIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84859320748     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032037     Document Type: Article

References (57)

1. Wyndaele M, Wyndaele J, (2006) Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord 44: 523-529.
2. Fehlings M, Sekhon L, eds. (2000) Cellular, ionic and biomolecular mechanisms of the injury process Chicago American Association of Neurologic Surgeons pp. 33-50.
3. Tator C, Fehlings M, (1991) Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Nerosurg 75: 15-26.
4. Amar A, Levy M, (1999) Pathogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury. Neurosurgery 44: 1027-1039.
5. Brodkey J, Richards D, Blasingame J, Nulsen F, (1972) Reversible spinal cord trauma in cats. Additive effects of direct pressure and ischemia. J Neurosurgery 37: 591-593.
6. Carlson G, Minato Y, Okada A, Gorden C, Warden K, et al. (1997) Early time-dependent decompression for spinal cord injury: Vascular mechanisms of recovery. J Neurotrauma 14: 951-962.
7. Delamarter R, Sherman J, Carr J, (1995) Pathophysiology of spinal cord injury. Recovery after immediate and delayed decompression. J Bone Joint Surg Am 77: 1042-1049.
8. Dimar J, Glassman S, Raque G, Zhang Y, Shields C, (1999) The influence of spinal canal narrowing and timing of decompression on neurologic recovery after spinal cord contusion in a rat model. Spine 24: 1623-1633.
9. Dolan E, Tator C, Endrenyi L, (1980) The value of decompression for acute experimental spinal cord compression injury. J Neurosurgery 53: 749-755.
10. Guha A, Tator C, Endrenyi L, (1987) Decompression of the spinal cord improves recovery after acute experimental spinal cord compression injury. Paraplegia 25: 324-339.
11. Kobrine A, Evans D, Rizzoli H, (1979) Experimental acute balloon compression of the spinal cord. Factors affecting disappearance and return of the spinal evoked response. J Neurosurgery 51: 841-845.
12. Nystrom B, Berglund J, (1988) Spinal cord restitution following compression injuries in rats. Acta Neurol Scand 78: 467-472.
13. Tarlov I, (1954) Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs. AMA Arch Neurol Psychiatry 71: 588-597.
14. Tarlov I, Klinger H, (1954) Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs. AMA Arch Neurol Psychiatry 71: 271-290.
15. Carlson G, Gorden C, Oliff H, Pillai J, LaManna J, (2003) Sustained spinal cord compression: Part I: Time-dependent effect on long-term pathophysiology. J Bone Joint Surg Am 85: 86-94.
16. Papadopoulos S, Selden N, Quint D, Patel N, Gillespie B, et al. (2002) Immediate spinal cord decompression for cervical spinal cord injury: Feasibility and outcome. J Trauma 52: 323-332.
17. Waters R, Adkins R, Yakura J, Sie I, (1996) Effect of surgery on motor recovery following traumatic spinal cord injury. Spinal Cord 34: 188-192.
18. Vaccaro A, Daugherty R, Sheehan T, Dante S, Cotler J, et al. (1997) Neurologic outcome of early versus late surgery for cervical spinal cord injury. Spine 22: 609-612.
19. McKinley W, Meade M, Kirshblum S, Barnard B, (2004) Outcomes of early surgical management versus late or no surgical intervention after acute spinal cord injury. Arch Phys Med Rehabil 85: 1818-1825.
20. LaRosa G, Conti A, Cardali S, Cacciola F, Tomasello F, (2004) Does early decompression improve neurological outcome of spinal cord injured patients? Appraisal of the literature using a meta-analytical approach. Spinal Cord 42: 503-512.
21. Fehlings M, Rabin D, Sears W, Cadotte D, Aarabi B, (2010) Current practice in the timing of surgical intervention in spinal cord injury. Spine 35: 166-173.
22. Geisler F, Coleman W, Grieco G, Poonian D, (2001) The Sygen multicenter acute spinal cord injury study. Spine 26: 87-98.
23. Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, et al. (1997) Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277: 1597-1604.
24. Bracken M, Collins W, Freeman D, Shepard M, Wagner F, et al. (1984) Efficacy of methylprednisolone in acute spinal cord injury. JAMA 251: 45-52.
25. Bracken M, Shepard M, Collins W, Holford T, Young W, et al. (1990) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 322: 1405-1411.
26. Burns A, Ditunno J, (2001) Establishing Prognosis and Maximizing Functional Outcomes after Spinal Cord Injury. Spine 26: S137-S145.
27. Waters R, (1998) Munro lecture: functional and neurologic recovery following acute SCI. J Spinal Cord Med 21: 195-199.
28. Fehlings M, Rao S, Tator C, Skaf G, Arnold P, et al. (1999) The Optimal Radiologic Method for Assessing Spinal Canal Compromise and Cord Compression in Patients with Cervical Spinal Cord Injury Part 2: Results of a multicenter study. Spine 24: 605-613.
29. Hadley M, Walters B, Grabb P, Oyesiku N, Przybylski G, et al. (2002) Blood pressure management after acute spinal cord injury. Neurosurgery 50: S58-62.
30. Hadley M, Walters B, Grabb P, Oyesiku N, Przybylski G, et al. (2002) Management of Acute Spinal Cord Injuries in an Intestive Care Unit or Other Monitored Setting. Neurosurgery S51-57.
31. Hadley M, Walters B, Grabb P, Oyesiku N, Przybylski G, et al. (2002) Pharmacological Therapy after Acute Cervical Spinal Cord Injury. Neurosurgery 50: 563-572.
32. Pointillart V, Petitjean M, Wiart L, Vital J, Laisse P, et al. (2000) Pharmacological therapy of spinal cord injury during the acute phase. Spinal Cord 38: 71-76.
33. McKinley W, Meade M, Kirshblum S, Barnard B, (2004) Outcomes of early surgical management versus late or no surgical intervention after acute spinal cord injury. Arch Phys Med Rehab 85: 1818-1825.
34. Furlan J, Noonan V, Cadotte D, Fehlings M, (2009) Timing of Decompressive Surgery of Spinal Cord after Traumatic Spinal Cord Injury: An Evidence-Based Examination of Pre-Clinical and Clinical Studies. J Neurotrauma 27: 1-29.
35. Botel U, Glaser E, Niedeggen A, (1997) The surgical treatment of acute spinal paralysed patients. Spinal Cord 35: 420-428.
36. Campagnolo D, Esquieres R, Kopacz K, (1997) Effect of timing of stabilization on length of stay and medical complications following spinal cord injury. J Spinal Cord Med 20: 331-334.
37. Duh M, Shepard M, Wilberger J, Bracken M, (1994) The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment. Neurosurgery 35: 240-248.
38. Guest J, Eleraky M, Apostolides P, Dickman C, Sonntag V, (2002) Traumatic central cord syndrome: results of surgical management. J Neurosurgery 97: 25-32.
39. Krengel W, Anderson P, Henley M, (1993) Early stabilization and decompression for incomplete paraplegia due to a thoracic-level spinal cord injury. Spine 18: 2080-2087.
40. Levi L, Wolf A, Rigamonti D, Ragheb J, Mirvis S, et al. (1991) Anterior decompression in cervical spine trauma: does the timing of surgery affect the outcome. Neurosurgery 29: 216-222.
41. McLain R, Benson D, (1999) Urgent surgical stabilization of spinal fractures in polytrauma patients. Spine 24: 1646-1654.
42. Pollard M, Apple D, (2003) Factors associated with improved neurologic outcomes in patients with incomplete tetraplegia. Spine 2003: 33-39.
43. Tator C, Fehlings M, Thorpe K, Taylor W, (1999) Current use and timing of spinal surgery for management of acute spinal surgery for management of acute spinal cord injury in North America: results of a retrospective multicenter study. J Neurosurgery 91: 12-18.
44. Chipman J, Deuser W, Beilman G, (2004) Early surgery for thoracolumbar spine injuries decreases complications. J Trauma 56: 52-57.
45. Croce M, Bee T, Pritchard E, Miller P, Fabian T, (2001) Does optimal timing for spine fracture fixation exist. Ann Surg 233: 851-858.
46. Kerwin A, Frykberg E, Schinco M, Griffen M, Murphy T, et al. (2005) The effect of early spine fixation on non-neurologic outcome. J Trauma 58: 15-21.
47. Mirza S, Krengel W, Chapman J, Anderson P, Bailey J, et al. (1999) Early versus delayed surgery for acute cervical spinal cord injury. Clin Orthop Relat Res 359: 104-114.
48. Sapkas G, Papadakis S, (2007) Neurological outcome following early versus delayed lower cervical spine surgery. J Orthop Surg 15: 183-186.
49. Schinkel C, Frangen T, Kmetic A, Andress H, Muhr G, (2006) Timing of thoracic spine stabilization in trauma patients: impact on clinical course and outcome. J Trauma 61: 156-160.
50. Cengiz S, Kalkan E, Bayir A, Ilik K, Basefer A, (2008) Timing of thoracolomber spine stabilization in trauma patients; impact on neurological outcome and clinical course. A real prospective (rct) randomized controlled study. Arch Orthop Trauma Surg 128: 959-966.
51. Ng W, Fehlings M, Cuddy B, Dickman C, Fazl M, et al. (1999) Surgical treatment for acute spinal cord injury study pilot study #2: evaluation of protocol for decompressive surgery within 8 h of injury. Neurosurg Focus 6: e3.
52. Clohisy J, Akbarnia B, Bucholz R, Burkus J, Backer R, (1992) Neurologic recovery associated with anterior decompression of spine fractures at the thoracolumbar junction (T12-L1). Spine 17: 325-330.
53. Chen L, Yang H, Yang T, Xu Y, Bao Z, et al. (1997) Effectiveness of surgical treatment for traumatic central cord syndrome. J Neurosurgery Spine 10: 3-8.
54. Fawcett J, Curt A, Steeves J, Coleman W, Tuszynski M, et al. (2007) Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic trials. Spinal Cord 45: 190-205.
55. Furlan JC, Fehlings MG, Tator CH, Davis AM, (2008) Motor and sensory assessment of patients in clinical trials for pharmacological therapy of acute spinal cord injury: psychometric properties of the ASIA Standards. J Neurotrauma 25: 1273-1301.
56. Maynard F, Reynolds G, Fountain S, Wilmot C, Hamilton R, (1979) Neurologic prognosis after traumatic quadriplegia. J Neurosurgery 50: 611-616.
57. Ditunno J, Little J, Tessler A, Burns A, (2004) Spinal shock revisited: a four phase model. Spinal Cord 42: 383-395.