Non-hormonal topical treatment of vulvovaginal atrophy: An up-to-date overview

Climacteric

Volumn 16, Issue 3, 2013, Pages 305-312

  Sinha, A ^a   Ewies, A A A ^a  

^a SANDWELL AND WEST BIRMINGHAM HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Dyspareunia; Vaginal Dryness; Vaginal Lubricants; Vaginal Moisturizers; Vulvovaginal Atrophy

Indexed keywords

ALPHA TOCOPHEROL; AQUAGEL; ASTROGLIDE; EMERITA; ESTRADIOL; ESTROGEN; GENISTEIN; HYALO GY; HYALOFEMME; HYALURONIC ACID; K Y JELLY; LIQUID SYLK; LUBRICATING AGENT; PHYTOESTROGEN; PHYTOSOYA; POLYCARBOPHIL; RALOXIFENE; REPADINA; REPHRESH; SLIPPERY STUFF; SUMMERS EVE; UNCLASSIFIED DRUG; VAGINAL LUBRICANT; VAGINAL MOISTURIZER; YES;

ABSENCE OF SIDE EFFECTS; BREAST CANCER; BURNING SENSATION; CANCER SURVIVOR; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG USE; DYSPAREUNIA; ESTROGEN THERAPY; FEMALE; HEALTH CARE PERSONNEL; HUMAN; HUMIDIFIER; PRIORITY JOURNAL; REVIEW; SEXUAL BEHAVIOR; VAGINA ATROPHY; VAGINAL DRYNESS; VAGINAL PRURITUS;

ADMINISTRATION, INTRAVAGINAL; AGED; ATROPHY; BREAST NEOPLASMS; COITUS; DYSPAREUNIA; ESTROGENS; FEMALE; HUMANS; LIPIDS; LUBRICANTS; MENOPAUSE; MIDDLE AGED; QUALITY OF LIFE; SEXUAL BEHAVIOR; SURVIVORS; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINAL DISEASES; VULVA;

EID: 84877820852     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.3109/13697137.2012.756466     Document Type: Review

References (53)

1. Al-Baghdadi O , Ewies AAA . Topical estrogen therapy in the management of postmenopausal vaginal atrophy: an up-to-date overview . Climacteric 2009 ; 12 : 91-105
2. Cobleigh MA , Berris RF, Bush T, et al . Estrogen replacement therapy in breast cancer survivors . A time for change. Breast Cancer Committees of the Eastern Cooperative Oncology Group. JAMA 1994 ; 272 : 540-5
3. Hill K . T he demography of menopause. M aturitas 1996; 2 3: 113-27
4. Calleja-Agius J , B rincat M P . U rogenital atrophy . C limacteric 2009 ; 12 : 279-85
5. Sturdee D W , P anay N . R ecommendations for the management of postmenopausal vaginal atrophy . Climacteric 2010 ; 13 : 509-22
6. Pastore LM , Carter RA , Hulka BS , Wells E . Self-reported urogenital symptoms in postmenopausal women: Women ' s Health Initiative . Maturitas 2004 ; 49 : 292-303
7. Stenberg A , H eimer G , U lmsten U , C nattingius S . P revalence of genitourinary and other climacteric symptoms in 61-year-old women . Maturitas 1996 ; 24 : 31-6
8. Ganz P A , G reendale G A , P etersen L , et a l . M anaging menopausal symptoms in breast cancer survivors: results of a randomized controlled trial . J Natl Cancer Inst 2000 ; 92 : 1054-64
9. Morales L , Neven P, Timmerman D , e t al . Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients . Anticancer Drugs 2004 ; 15 : 753-60
10. Cardozo L , Bachmann G , McClish D , Fonda D , Birgerson L . Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee . Obstet Gynecol 1998 ; 92 : 722-7
11. Levine K B , W illiams R E , H artmann K E. V ulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women . Menopause 2008 ; 15 : 661-6
12. Dennerstein L , Dudley EC , Hopper JL , Guthrie JR, Burger HG . A prospective population-based study of menopausal symptoms . Obstet Gynecol 2000 ; 96 : 351-8
13. Nappi R E , K okot-Kierepa M . V aginal Health: Insights, Views & Attitudes (VIVA): results from an international survey . Climacteric 2012 ; 15 : 36-44
14. Nappi R E , K okot-Kierepa M . W omen' s voices in the menopause: results from an international survey on vaginal atrophy . Maturitas 2010 ; 67 : 233-8
15. Barlow D H , S amsioe G , v an Geelen J M . A study of European womens ' experience of the problems of urogenital ageing and its management . Maturitas 1997 ; 27 : 239-47
16. Iosif CS, B ekassy Z . P revalence of genito-urinary symptoms in the late menopause . Acta Obstet Gynecol Scand 1984 ; 63 : 257-60
17. van Geelen JM, van de Weijer PH , Arnolds HT . U rogenital symptoms and resulting discomfort in non-institutionalized Dutch women aged 50-75 years . Int Urogynecol J Pelvic Floor Dysfunct 2000 ; 11 : 9-14
18. Kalogeraki A , Tamiolakis D , Tzardi M , et al . Cigarette smoking as a risk factor for intraepithelial lesion of the cervix uteri . In Vivo 1996 ; 10 : 613-16
19. Derzko C, E lliott S, L am W . M anagement of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy . Curr Oncol 2007 ; 14 : S20-40 Couzi
20. Couzi RJ, Helzlsouer KJ, Fetting JH . Prevalence of menopausal symptoms among women with a history of breast cancer and attitudes toward estrogen replacement therapy . J Clin Oncol 1995 ; 13 : 2737-44
21. Dew J E , W ren B G , E den J A . A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer . Climacteric 2003 ; 6 : 45-52
22. Vassilopoulou-Sellin R , Theriault R , Klein MJ . Estrogen replacement therapy in women with prior diagnosis and treatment for breast cancer . Gynecol Oncol 1997 ; 65 : 89-93
23. Loprinzi CL , A bu-Ghazaleh S , Sloan JA , et al . Phase III randomized double-blind study to evaluate the effi cacy of a polycarbophil-based vaginal moisturizer in women with breast cancer . J Clin Oncol 1997 ; 15 : 969-73
24. SOGC clinical practice guidelines . The detection and management of vaginal atrophy . Number 145 , May 2004 . Int J Gynaecol Obstet 2005;88:222-8
25. Nachtigall L E . C omparative study: Replens versus local estrogen in menopausal women . Fertil Steril 1994 ; 61 : 178-80
26. Gelfand M M , W endman E . T reating Vaginal dryness in breast cancer patients: results of applying a polycarbophil moisturizing gel . J Women ' s Health 1994 ; 3 : 427-34
27. Hubbard GB , C arey KD, L evine H , Bachmann GA . E valuation of a vaginal moisturizer in baboons with decreasing ovarian function . Lab Anim Sci 1997 ; 47 : 36-9
28. Bygdemann M , Swahn ML . Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women . Maturitas 1996 ; 23 : 259-63
29. van der Laak JAWM , de Bie LMT , de Leeuw H , de Wilde PCM , Hanselaar AGJM . The effect of Replens on vaginal cytology in the treatment of postmenopausal atrophy: cytomorphology versus computerised cytometry . J Clin Pathol 2002 ; 55 : 446-51
30. Parsons A , Merritt D , Rosen A , et al . Effect of raloxifene on the response to conjugated estrogen vaginal cream or nonhormonal moisturizers in postmenopausal vaginal atrophy . Obstet Gynecol 2003 ; 101 : 346-52
31. Caswell M , K ane M . C omparison of the moisturization effi cacy of two vaginal moisturizers: Pectin versus polycarbophil technologies . J Cosmet Sci 2002 ; 53 : 81-7
32. EMERITA: R etrieved at h ttp://www.emerita.com/. Accessed July 10, 2012
33. Tan O , Bradshaw K , Carr BR . Management of vulvovaginal atrophy-related sexual dysfunction in postmenopausal women: an up-to-date review . Menopause 2012 ; 19 : 109-17
34. RepHresh. Retrieved at: http://www.rephresh.co.uk/. Accessed July 10 , 2012
35. Organic Personal Lubricants. Retrieved at : http://www.yesyesyes. org/. Accessed June 25, 2012
36. Hyalo GYN . Retrieved at: http://www.hyalogyn.com/. Accessed June 25, 2012
37. Hyalofemme . Retrieved at: http://www.hyalofemme.co.uk/. Accessed July 11, 2012
38. Ekin M , Ya sa r L , Savan K , et al . The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial . Arch Gynecol Obstet 2011 ; 283 : 539-43
39. Le Donne M , Caruso C , Mancuso A , et al . The effect of vaginally administered genistein in comparison with hyaluronic acid on atrophic epithelium in postmenopause . Arch Gynecol Obstet 2011 ; 283 : 1319-23
40. Morali G , P olatti F , M etelitsa E N , et a l . O pen, non-controlled clinical studies to assess the effi cacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy . Arzneimittelforschung 2006 ; 56 : 230-8
41. Prescription drug database and drug prescribing guide | MIMS online . Retrieved at : http://www.mims.co.uk/. Accessed July 16, 2012
42. Adriaens E , Remon JP . Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay . Sex Transm Dis 2008 ; 35 : 512-16
43. K-Y Jelly . Wikipedia . Retrieved at: http://en.wikipedia.org/wiki/K-Y- Jelly . Accessed June 25, 2012
44. BNF.org . Retrieved at: http://www.bnf.org/. Accessed July 16, 2012
45. SYLK . R etrieved at: h ttp://www.sylk.co.uk/. Accessed June 25, 2012
46. AquaGel . Retrieved at http://www.wms.co.uk/. Accessed July 11, 2012
47. Boots Health and Beauty, Pharmacy. and Prescriptions, UK Chemist -Boots . Retrieved at : http://www.boots.com/. Accessed June 25, 2012
48. RxList-The Internet Drug Index for prescription drugs, medications and pill identifi er . Retrieved at : http://www.rxlist.com/script/main/hp.asp . Accessed July 16, 2012
49. Astroglide . Retrieved at: http://en.wikipedia.org/wiki/Astroglide. Accessed June 25, 2012
50. Slippery Stuff Gel . R etrieved at: h ttp://www.wallace-ofarrell. com/. Accessed June 25, 2012
51. Castelo-Branco C , Rostro F . Treatment of atrophic vaginitis. Therapy 2007 ; 4 : 349-53
52. Bachmann GA , Nevadunsky NS . Diagnosis and treatment of atrophic vaginitis . Am Fam Physician 2000 ; 61 : 3090-6
53. Leiblum S , Bachmann G , Kemmann E , Colburn D , Swartzman L . Vaginal atrophy in the postmenopausal woman: the importance of sexual activity and hormones . JAMA 1983 ; 249 : 2195-8