Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients;La metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con diabetes mellitus tipo 1

Revista Medica de Chile

Volumn 143, Issue 5, 2015, Pages 562-568

  Arroyo Jousse, Viviana ^a   García Díaz, Diego F ^a   Pérez Bravo, Francisco ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

DNA methylation; Epigenetics; Folate; Type 1 Diabetes

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADOLESCENT; ADULT; AGE; BLOOD; CHILD; DNA METHYLATION; FEMALE; GENETIC EPIGENESIS; GENETICS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; DIABETES MELLITUS, TYPE 1; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; YOUNG ADULT;

EID: 84937020204     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: 10.4067/s0034-98872015000500002     Document Type: Article

References (40)

1. Pugliese A. The multiple origins of Type 1 diabetes. Diabet Med 2012; 30 (2): 135-46
2. Atkinson MA. The pathogenesis and natural history of type 1 diabetes. Cold Spring Harb Perspect Med 2012; 2 (11): 1-18
3. Canivell S, Gomis R. Diagnosis and classification of autoimmune diabetes mellitus. Autoimmun Rev 2014; 13 (4-5): 403-7
4. Nokoff N, Rewers M. Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. Ann N Y Acad Sci. 2013; 1281: 1-15
5. Santos J, Carrasco E, Moore A, Pérez-Bravo F, Albala C. Incidence rate and spatio-temporal clustering of Type 1 Diabetes in Santiago, Chile, from 1997 to 1998. Saúde Pública 2001; 35 (1): 96-100
6. Carrasco E, Angel B, Codner E, García D, Ugarte F, Bruzzone ME, et al. [Type 1 diabetes mellitus incidence in Santiago, Chile. Analysis by counties in the period 2000-2004]. Rev Med Chile 2006; 134 (10): 1258-64
7. Adeghate E, Schattner P, Dunn E. An update on the etiology and epidemiology of diabetes mellitus. Ann N Y Acad Sci 2006; 1084: 1-29
8. Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, et al. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes- indication of an increased environmental pressure? Diabetologia 2003; 46 (3): 420-5
9. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41 (6): 703-7
10. Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, et al. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia 2001; 44 (3): 354-62
11. Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 2003; 52 (4): 1052-5
12. Knip M, Simell O. Environmental triggers of type 1 diabetes. Cold Spring Harb Perspect Med 2012; 2 (7): 1-15
13. Hewagama A, Richardson B. The genetics and epigenetics of autoimmune diseases. J Autoimmun 2009; 33 (1): 3-11
14. Anderson OS, Sant KE, Dolinoy DC. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem 2012; 23 (8): 853-9
15. Stankov K, Benc D, Draskovic D. Genetic and epigenetic factors in etiology of diabetes mellitus type 1. Pediatrics 2013; 132 (6): 1112-22
16. Dang MN, Buzzetti R, Pozzilli P. Epigenetics in autoimmune diseases with focus on type 1 diabetes. Diabetes Metab Res Rev 2013; 29 (1): 8-18
17. Ly A, Hoyt L, Crowell J, Kim YI. Folate and DNA methylation. Antioxid Redox Signal 2012; 17 (2): 302-26
18. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16 (1): 6-21
19. Rakyan VK, Beyan H, Down TA, Hawa MI, Maslau S, Aden D, et al. Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet 2011; 7 (9): 1-9
20. Disanto G, Vcelakova J, Pakpoor J, Elangovan RI, Sumnik Z, Ulmannova T, et al. DNA methylation in monozygotic quadruplets affected by type 1 diabetes. Diabetologia 2013; 56 (9): 2093-5
21. Stefan M, Zhang W, Concepcion E, Yi Z, Tomer Y. DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology. J Autoimmun 2013; 50: 33-7
22. Saeed BO, Banerjee K, Nixon SJ, Brown K. Plasma homocysteine concentrations in patients with Type 1 diabetes. Diabet Med 2003; 20 (10): 867-8
23. Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition 2012; 28 (7-8): e23-6
24. Nazki FH, Sameer AS, Ganaie BA. Folate: metabolism, genes, polymorphisms and the associated diseases. Gene 2014; 533 (1): 11-20
25. Wijekoon P, Brosnan M, Brosnan J. Homocysteine Metabolism in Diabetes. In: S. K. Cheema, editor. Biochemestry of Atherosclerosis. New York: Springer; 2006
26. Finkelstein JD. The metabolism of homocysteine: pathways and regulation. Eur J Pediatr 1998; 157 Suppl 2: S40-4
27. Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes 1998; 47 (12): 1967-70
28. Chiang EP, Wang YC, Chen WW, Tang FY. Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation. J Clin Endocrinol Metab 2009; 94 (3): 1017-25
29. Abu-Lebdeh HS, Barazzoni R, Meek SE, Bigelow ML, Persson XM, Nair KS. Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes. J Clin Endocrinol Metab 2006; 91 (9): 3344-8
30. Williams KT, Garrow TA, Schalinske KL. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr 2008; 138 (11): 2064-9
31. Jacobs RL, Stead LM, Brosnan ME, Brosnan JT. Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. J Biol Chem 2001; 276 (47): 43740-7
32. Meloni GF, Tonolo GC, Zuppi C, Zappacosta B, Musumeci S. Hyper-homocysteinemia is not a main feature of juvenile uncomplicated type 1 diabetes. J Atheroscler Thromb 2005; 12 (1): 14-9
33. Salardi S, Cacciari E, Sassi S, Grossi G, Mainetti B, Dalla Casa C, et al. Homocysteinemia, serum folate and vitamin B12 in very young patients with diabetes mellitus type 1. J Pediatr Endocrinol Metab 2000; 13 (9): 1621-7
34. Veldman BA, Vervoort G, Blom H, Smits P. Reduced plasma total homocysteine concentrations in Type 1 diabetes mellitus is determined by increased renal clearance. Diabet Med 2005; 22 (3): 301-5
35. Elbert A. Enfermedad Renal en Pacientes con Diabetes Mellitus. In: M. García de los Ríos y P. Durruty, editores. Diabetes Mellitus. 3era ed. Santiago: Mediterráneo Ltda.; 2014. p. 227-39
36. Abdel Aziz MT, Fouad HH, Mohsen GA, Mansour M, Abdel Ghaffar S. TNF-alpha and homocysteine levels in type 1 diabetes mellitus. East Mediterr Health J. 2001; 7 (4-5): 679-88
37. Saeed BO, Nixon SJ, White AJ, Summerfield GP, Skillen AW, Weaver JU. Fasting homocysteine levels in adults with type 1 diabetes and retinopathy. Clin Chim Acta 2004; 341 (1-2): 27-32
38. Agullo-Ortuno MT, Albaladejo MD, Parra S, Rodríguez- Manotas M, Fenollar M, Ruiz-Espejo F, et al. Plasmatic homocysteine concentration and its relationship with complications associated to diabetes mellitus. Clin Chim Acta 2002; 326 (1-2): 105-12
39. Vaccaro O, Perna AF, Mancini FP, Iovine C, Cuomo V, Sacco M, et al. Plasma homocysteine and microvascular complications in type 1 diabetes. Nutr Metab Cardiovasc Dis 2000; 10 (6): 297-304
40. Tessari P, Coracina A, Kiwanuka E, Vedovato M, Vettore M, Valerio A, et al. Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy. Diabetes 2005; 54 (10): 2968-76.