MiR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

Cell Death and Differentiation

Volumn 24, Issue 7, 2017, Pages 1205-1213

  Li, Z ^a   Song, Y ^b   Liu, L ^a   Hou, N ^a   An, X ^b   Zhan, D ^c   Li, Y ^d   Zhou, L ^e   Li, P ^e   Yu, L ^d   Xia, J ^f   Zhang, Y ^b   Wang, J ^a   Yang, X ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d PEKING UNIVERSITY   (China)

^e Tsinghua University   (China)

^f HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; AUTOPHAGY RELATED PROTEIN 12; AUTOPHAGY RELATED PROTEIN 5; BECLIN 1; BRAIN NATRIURETIC PEPTIDE; CHLOROQUINE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GLYCOGEN SYNTHASE KINASE 3BETA; LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA; MICRORNA 199A; MYOSIN HEAVY CHAIN BETA; PROTEIN S6; RAPAMYCIN; SEQUESTOSOME 1; UNCLASSIFIED DRUG; MIRN199 MICRORNA, MOUSE; TARGET OF RAPAMYCIN KINASE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BODY WEIGHT; CARDIAC MUSCLE CELL; CELL COUNT; CELL PROLIFERATION; CELL SIZE; CELL SURFACE; CELL VACUOLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FLUX ASSAY; GENE EXPRESSION; HEART EJECTION FRACTION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART SIZE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; LYSOSOME; M MODE ECHOCARDIOGRAPHY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYSTOLE; ULTRASTRUCTURE; UPREGULATION; ANIMAL; CARDIOMEGALY; ENZYME ACTIVATION; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RAT; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGOSOMES; AUTOPHAGY; CARDIOMEGALY; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3 BETA; MICE, TRANSGENIC; MICRORNAS; MYOCYTES, CARDIAC; RATS; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84936976942     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.95     Document Type: Article

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