Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter

Toxicology Letters

Volumn 237, Issue 3, 2015, Pages 228-236

  Khnal, Tilak ^a   Kim, Dasom ^a   Johnson, Abby ^a   Choubey, Divaker ^a   Kim, Kyounghyun ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

An orphan nuclear receptor; Antioxidant; Epigenetics; Histone demethylase; Polycyclic aromatic hydrocarbon

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A1; ESTROGEN RECEPTOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; MESSENGER RNA; NUCLEAR RECEPTOR NR2E3; ORPHAN NUCLEAR RECEPTOR; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG; ANTIOXIDANT; HISTONE; NR2E3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL DAMAGE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DIMERIZATION; DOWN REGULATION; EPIGENETICS; HISTONE ACETYLATION; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HEPG2 CELL LINE; MCF 7 CELL LINE; METABOLISM;

ANIMALS; ANTIOXIDANTS; BENZO(A)PYRENE; DOWN-REGULATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HISTONES; HUMANS; MALE; MCF-7 CELLS; MICE; MICE, INBRED C57BL; ORPHAN NUCLEAR RECEPTORS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; RECEPTORS, ESTROGEN;

EID: 84936970758     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.06.1708     Document Type: Article

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